Synthesis, characterization and blood compatibilities of novel segmented polyurethanes containing poly(butadiene) soft segments and phosphatidylcholine analogues in the main chains and long-chain alkyl groups in the side chains

1999 ◽  
Vol 9 (3) ◽  
pp. 647-653 ◽  
Author(s):  
Arata Korematsu ◽  
Takayuki Murakami ◽  
Ikuko Sakurai ◽  
Makoto Kodama ◽  
Tadao Nakaya
Keyword(s):  
Side Chains ◽  
Alkyl Groups ◽  
Soft Segments ◽  
Segmented Polyurethanes ◽  
Long Chain

Synthesis and blood compatibilities of novel segmented polyurethanes containing phosphatidylcholine analogous moieties in the main chains and long-chain alkyl groups in the side chains

1999 ◽  
Vol 14 (9) ◽  
pp. 3789-3798 ◽  
Author(s):  
Arata Korematsu ◽  
Yu-Jun Li ◽  
Takayuki Murakami ◽  
Tadao Nakaya
Keyword(s):  
Platelet Adhesion ◽  
Platelet Rich Plasma ◽  
Side Chains ◽  
Alkyl Groups ◽  
Low Degree ◽  
Soft Segments ◽  
Hard Segments ◽  
Segmented Polyurethanes ◽  
Methylenediphenyl Diisocyanate ◽  
Long Chain

New segmented polyurethanes containing phospholipid moieties in the main chains and long-chain alkyl groups in the side chains were synthesized. The soft segments used in this study were poly(butadiene), poly(isoprene), hydrogenated poly(isoprene), and poly(1,6-hexyl-1,2-ethylcarbonate) diol. The hard segments of these polyurethanes were 4,4′-methylenediphenyl diisocyanate, bis[2-(2-hydroxyethyldimethylammonio)ethyl]2-cetyl- 1,3-propanediphosphate, and 1,4-butanediol. The blood compatibilities of the new polymers were evaluated by platelet-rich plasma contact studies and viewed by scanning electron microscopy using medical grade BioSpan® and nonphospholipid polyurethane as references. These new materials have good surfaces in terms of platelet adhesion, and the morphology of adhered platelets undergoes a relatively low degree of variation.

Synthesis of comb-like polyurethanes containing hydrophilic phosphatidylcholine analogues in the main chains and hydrophobic long chain alkyl groups in the side chains

1996 ◽  
Vol 17 (10) ◽  
pp. 737-744 ◽  
Author(s):  
Yu-Jun Li ◽  
Naotoshi Nakamura ◽  
Tian-Ming Chen ◽  
Yan-Feng Wang ◽  
Masaya Kitamura ◽  
...  
Keyword(s):  
Side Chains ◽  
Alkyl Groups ◽  
Long Chain
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