scholarly journals Pim-1 Expression in Rat Retina and its Changes after Optic Nerve Crush

2018 ◽  
Vol 301 (11) ◽  
pp. 1968-1976
Author(s):  
Shoumei Zhang ◽  
Dong Wang ◽  
Tingting Huang ◽  
Fang Liu ◽  
Li Shuai ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Rat Retina

scholarly journals Alterations in the expression of Hs1-associated protein X-1 in the rat retina after optic nerve crush

2016 ◽  
Vol 14 (5) ◽  
pp. 4761-4766 ◽  
Author(s):  
Ling Cui ◽  
Wen-Jing He ◽  
Fan Xu ◽  
Li Jiang ◽  
Ming-Liang Lv ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Rat Retina ◽  
Protein X

scholarly journals miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1564
Author(s):  
Ben Mead ◽  
Alicia Kerr ◽  
Naoki Nakaya ◽  
Stanislav I. Tomarev
Keyword(s):  
Optic Nerve ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Rat Retina ◽  
Retinal Injury ◽  
Generation Sequencing

The purpose of this study was to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Diseased retina includes those after a traumatic optic nerve crush (ONC), and after ocular hypertension/glaucoma. Rats were separated into four groups: healthy/intact, 7 days after laser-induced ocular hypertension, 2 days after traumatic ONC, and 7 days after ONC. RGC were purified from rat retina using microbeads conjugated to CD90.1/Thy1. RNA were sequenced using Next Generation Sequencing. Over 100 miRNA were identified that were significantly different in diseased retina compared to healthy retina. Considerable differences were seen in the miRNA expression of RGC 7 days after ONC, whereas after 2 days, few changes were seen. The miRNA profiles of RGC 7 days after ONC and 7 days after ocular hypertension were similar, but discrete miRNA differences were still seen. Candidate mRNA showing different levels of expression after retinal injury were manipulated in RGC cultures using mimics/AntagomiRs. Of the five candidate miRNA identified and subsequently tested for therapeutic efficacy, miR-194 inhibitor and miR-664-2 inhibitor elicited significant RGC neuroprotection, whereas miR-181a mimic and miR-181d-5p mimic elicited significant RGC neuritogenesis.

Temporal response of the phagocytic microglia in the axotomized rat retina: optic nerve crush vs. transection

2014 ◽  
Vol 92 ◽  
pp. 0-0 ◽  
Author(s):  
FM NADAL-NICOLAS ◽  
M JIMENEZ-LOPEZ ◽  
M SALINAS-NAVARRO ◽  
L NIETO-LOPEZ ◽  
I CANOVAS-MARTINEZ ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Temporal Response ◽  
Nerve Crush ◽  
Rat Retina

Metabolomic Changes in the Rat Retina After Optic Nerve Crush

2013 ◽  
Vol 54 (6) ◽  
pp. 4249 ◽  
Author(s):  
Marta Agudo-Barriuso ◽  
Agustín Lahoz ◽  
Francisco M. Nadal-Nicolás ◽  
Paloma Sobrado-Calvo ◽  
Marina Piquer-Gil ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Nerve Crush ◽  
Rat Retina

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Persimmon Leaves (Diospyros kaki) Extract Protects Optic Nerve Crush-Induced Retinal Degeneration

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hong Ryul Ahn ◽  
Kyung-A Kim ◽  
Suk Woo Kang ◽  
Joo Young Lee ◽  
Tae-Jin Kim ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Degeneration ◽  
Diospyros Kaki ◽  
Optic Nerve Crush ◽  
Nerve Crush
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