scholarly journals Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Dongxian Jiang ◽  
Yalan Liu ◽  
Hao Wang ◽  
Haixing Wang ◽  
Qi Song ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

506 TO STUDY THE CLINICAL IMPACT AND PROGNOSTIC VALUE OF TUMOR INFILTRATING LYMPHOCYTES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
N Uma Baskaran ◽  
A M ◽  
S Rajendiran
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Good Prognosis ◽  
Tumour Tissue ◽  
Stromal Compartment ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Abstract   Esophageal cancer is the sixth most common cause of death due to cancer worldwide, of which Esophageal Squamous cell carcinoma (ESCC) is the most prevalent type. The presence of Tumour Infiltrating Lymphocytes (TILs) in a tumour indicates a good prognosis of the cancer following immunotherapy. Numeral immunological inhibitors have been developed to treat a variety of cancers, however the role of TILs in ESCC has not been substantiated with proper evidence. Methods The study enrolled 27 patients of ESCC between the years 2014–2019.The evaluation was based on the criteria laid down by the International TILs Working Group 2014 (recorded in percentage based on the area of stromal compartment invaded by the mononuclear inflammatory cells). Scoring was done in 400x field as follows: Score 0- No infiltrating lymphocytes. Score 1- Mild increase in infiltrating lymphocytes in the tumour nest or stroma. Score 2- Increase in infiltrating lymphocytes interwoven with the tumour tissue. Score 3- Prominent infiltrating lymphocytes incorporated in the tumour tissue. Results A total of 27 cases were studied, of which 17 were males (63%) and 10 were females (37%). The commonest age group was 60–70 years (12 cases- 44.4%). 22 cases had tumours sized between 3-7 cm (81.4%). pT1–1 case (0.03%). pT2–10 cases (37.03%). pT3–16 cases (59.25%). TILs were further scored based on the standard scoring system, and the results were as follows: Score 0 in 3 cases (11.11%). Score 1 in 14 cases (51.8%). Score 2 in 4 cases (14.8%). Score 3 in 6 cases (22.22%). Conclusion In conclusion, the commonest score of 1 was seen in 51.8% of the cases and that of score 3 was seen in 22.22% of the cases. Tumour Infiltrating Lymphocytes can hence serve as a predictor for good prognosis of Esophageal Squamous Cell Carcinoma following surgery or radiotherapy/chemotherapy.

scholarly journals CLINICAL IMPACT AND PROGNOSTIC VALUE OF TUMOR INFILTRATING LYMPHOCYTES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2020 ◽  
pp. 1-4
Author(s):  
Nikitha Uma Baskaran ◽  
Arthi M ◽  
Swaminathan Rajendiran
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Good Prognosis ◽  
Age Group ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Background: Esophageal Squamous cell carcinoma is the most prevalent type of Esophageal cancer in the world. The presence of Tumour infiltrating lymphocytes indicates a good prognosis of the cancer and this may suggest a good response to immunotherapy. Numerous immunological inhibitors have been developed to treat a variety of cancers; however, the role of Tumour Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma has not been substantiated with proper evidence. Methodology: The study enrolled 27 patients of Esophageal Squamous Cell Carcinoma between the years 2014-2019. The evaluation was based on the criteria laid down by the International Tumour Infiltrating Lymphocytes Working Group 2014 and scoring of the same was done in 400x field and were reported. Results: A total of 27 cases were studied, of which 17 were males and 10 were females. The commonest age group was 60-70 years. 22 cases had tumours sized between 3-7cm. Tumour grading of pT1 was seen in 1 case, grading of pT2 in 10 cases and pT3 in 16 cases. Tumour Infiltrating Lymphocytes were scored based on the standard scoring system, and the results showed that 3 cases were of Score 0, 14 cases of Score 1, 4 cases of Score 2, and 6 cases of Score 3. Conclusion: The commonest score of 1 was seen in 51.8% of the cases and that of score 3 was seen in 22.22% of the cases. Tumour Infiltrating Lymphocytes can hence serve as a predictor for good prognosis of Esophageal Squamous Cell Carcinoma following surgery or radiotherapy/chemotherapy.

scholarly journals The presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in advanced hypopharyngeal squamous cell carcinoma

2020 ◽  
Author(s):  
Jie Wang ◽  
Shu Tian ◽  
Ji Sun ◽  
Jiahao Zhang ◽  
Lan Lin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immune Cells ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Free Survival ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Abstract Background: Cancer cells induce the infiltration of various immune cells that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We therefore studied the prognostic significance of the presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different types of immune cells in hypopharyngeal squamous cell carcinoma (HPSCC). Methods: We retrospectively analysed 132 consecutive patients diagnosed with advanced HPSCC in 2013-2017. Tumoural parenchyma was immunohistochemically counted manually for the number of CD8, CD4 and Foxp3 cells. The ratios of CD8/Foxp3 and CD8/CD4 ratios were calculated for each specimen and analyzed with respect to patient clinicopathological variables and prognosis. Results: HPSCC patients with high levels of TILs showed evident correlations with well differentiated tumors (P < 0.05). Moreover, Foxp3+ TIL is also associated with overall staging group and T category (P =0.048 and P= 0.046, respectively). Kaplan-Meier analysis showed that high CD8 and FoxP3 infiltration correlated with favourable overall survival (OS, P = 0.019 and P = 0.001), disease-free survival (DFS, P = 0.045 and P = 0.028) and distant metastasis-free survival (DMFS, P = 0.034 and P = 0.009), respectively, but only Foxp3 displayed prognostic significance for DMFS in multivariate analysis (MVA). In the lymphocyte ratio analysis, CD8/Foxp3 appeared to play a pivotal role, and patients with a high CD8/Foxp3 ratio had a superior 3-year DFS and DMFS compared with those a low CD8/Foxp3 ratio in both univariate analysis (UVA) and MVA (P = 0.015 and P=0.011). A high CD8/CD4 ratio was associated with better DFS and local relapse-free survival (LRFS) in UVA, and was an independent prognostic factor for improved LRFS in MVA (P = 0.040).Conclusion: Although high TILs levels were determined to be prognostically significant in advanced HPSCC, the ratios of these subsets may be more informative. Particularly, a higher ratio of CD8/Foxp3 accurately predicts prognosis for improved DFS and DMFS, and an increased CD8/CD4 ratio is an independent predictor for favourable LRFS.

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