scholarly journals Neoadjuvant Chemotherapy Increases PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma

2019 ◽  
Vol 39 (8) ◽  
pp. 4539-4548 ◽  
Author(s):  
EIJI FUKUOKA ◽  
KIMIHIRO YAMASHITA ◽  
TOMOKO TANAKA ◽  
RYUICHIRO SAWADA ◽  
YUTAKA SUGITA ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma

2017 ◽  
Vol 24 (12) ◽  
pp. 3763-3770 ◽  
Author(s):  
Tomoya Sudo ◽  
Ryosuke Nishida ◽  
Akihiko Kawahara ◽  
Kouhei Saisho ◽  
Koshi Mimori ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Clinical Impact ◽  
Infiltrating Lymphocytes

506 TO STUDY THE CLINICAL IMPACT AND PROGNOSTIC VALUE OF TUMOR INFILTRATING LYMPHOCYTES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2020 ◽  
Vol 33 (Supplement_1) ◽  
Author(s):  
N Uma Baskaran ◽  
A M ◽  
S Rajendiran
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Good Prognosis ◽  
Tumour Tissue ◽  
Stromal Compartment ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Abstract   Esophageal cancer is the sixth most common cause of death due to cancer worldwide, of which Esophageal Squamous cell carcinoma (ESCC) is the most prevalent type. The presence of Tumour Infiltrating Lymphocytes (TILs) in a tumour indicates a good prognosis of the cancer following immunotherapy. Numeral immunological inhibitors have been developed to treat a variety of cancers, however the role of TILs in ESCC has not been substantiated with proper evidence. Methods The study enrolled 27 patients of ESCC between the years 2014–2019.The evaluation was based on the criteria laid down by the International TILs Working Group 2014 (recorded in percentage based on the area of stromal compartment invaded by the mononuclear inflammatory cells). Scoring was done in 400x field as follows: Score 0- No infiltrating lymphocytes. Score 1- Mild increase in infiltrating lymphocytes in the tumour nest or stroma. Score 2- Increase in infiltrating lymphocytes interwoven with the tumour tissue. Score 3- Prominent infiltrating lymphocytes incorporated in the tumour tissue. Results A total of 27 cases were studied, of which 17 were males (63%) and 10 were females (37%). The commonest age group was 60–70 years (12 cases- 44.4%). 22 cases had tumours sized between 3-7 cm (81.4%). pT1–1 case (0.03%). pT2–10 cases (37.03%). pT3–16 cases (59.25%). TILs were further scored based on the standard scoring system, and the results were as follows: Score 0 in 3 cases (11.11%). Score 1 in 14 cases (51.8%). Score 2 in 4 cases (14.8%). Score 3 in 6 cases (22.22%). Conclusion In conclusion, the commonest score of 1 was seen in 51.8% of the cases and that of score 3 was seen in 22.22% of the cases. Tumour Infiltrating Lymphocytes can hence serve as a predictor for good prognosis of Esophageal Squamous Cell Carcinoma following surgery or radiotherapy/chemotherapy.

scholarly journals Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4473
Author(s):  
Takuro Yamauchi ◽  
Fumiyoshi Fujishima ◽  
Masatoshi Hashimoto ◽  
Junichi Tsunokake ◽  
Ryujiro Akaishi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Therapeutic Efficacy ◽  
Tumor Infiltrating Lymphocytes ◽  
Independent Prognostic Factor ◽  
Biopsy Specimens ◽  
Infiltrating Lymphocytes

Necroptosis is a pivotal process in cancer biology; however, the clinical significance of necroptosis in esophageal squamous cell carcinoma (ESCC) has remained unknown. Therefore, in this study, we aimed to verify the potential involvement of necroptosis in the clinical outcome, chemotherapeutic resistance, and tumor microenvironment of ESCC. Mixed lineage kinase domain-like protein (MLKL) and phosphorylated MLKL (pMLKL) were immunohistochemically examined in 88 surgically resected specimens following neoadjuvant chemotherapy (NAC) and 53 pre-therapeutic biopsy specimens, respectively. Tumor-infiltrating lymphocytes (TILs) were also evaluated by immunolocalizing CD3, CD8, and forkhead box protein 3 (FOXP3) in the residual tumors after NAC. High pMLKL status in the post-NAC resected specimens was significantly correlated with worse prognosis in ESCC patients. Multivariate analysis demonstrated that a high pMLKL status was an independent prognostic factor. In pre-NAC biopsy specimens, a high pMLKL status was significantly associated with a lower therapeutic efficacy. CD8+ TILs were significantly lower in the high-pMLKL group. FOXP3+ TILs were significantly higher in both high-MLKL and high-pMLKL groups. We first demonstrated pMLKL status as an independent prognostic factor in ESCC patients. Our study revealed the possible involvement of necroptosis in the immunosuppressive microenvironment, resulting in the attenuated therapeutic efficacy of NAC and eventual adverse clinical outcomes in ESCC.

scholarly journals CLINICAL IMPACT AND PROGNOSTIC VALUE OF TUMOR INFILTRATING LYMPHOCYTES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2020 ◽  
pp. 1-4
Author(s):  
Nikitha Uma Baskaran ◽  
Arthi M ◽  
Swaminathan Rajendiran
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Good Prognosis ◽  
Age Group ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Background: Esophageal Squamous cell carcinoma is the most prevalent type of Esophageal cancer in the world. The presence of Tumour infiltrating lymphocytes indicates a good prognosis of the cancer and this may suggest a good response to immunotherapy. Numerous immunological inhibitors have been developed to treat a variety of cancers; however, the role of Tumour Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma has not been substantiated with proper evidence. Methodology: The study enrolled 27 patients of Esophageal Squamous Cell Carcinoma between the years 2014-2019. The evaluation was based on the criteria laid down by the International Tumour Infiltrating Lymphocytes Working Group 2014 and scoring of the same was done in 400x field and were reported. Results: A total of 27 cases were studied, of which 17 were males and 10 were females. The commonest age group was 60-70 years. 22 cases had tumours sized between 3-7cm. Tumour grading of pT1 was seen in 1 case, grading of pT2 in 10 cases and pT3 in 16 cases. Tumour Infiltrating Lymphocytes were scored based on the standard scoring system, and the results showed that 3 cases were of Score 0, 14 cases of Score 1, 4 cases of Score 2, and 6 cases of Score 3. Conclusion: The commonest score of 1 was seen in 51.8% of the cases and that of score 3 was seen in 22.22% of the cases. Tumour Infiltrating Lymphocytes can hence serve as a predictor for good prognosis of Esophageal Squamous Cell Carcinoma following surgery or radiotherapy/chemotherapy.

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