scholarly journals The influence of AccD5 on AccD6 carboxyltransferase essentiality in pathogenic and non-pathogenic Mycobacterium

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jakub Pawelczyk ◽  
Albertus Viljoen ◽  
Laurent Kremer ◽  
Jaroslaw Dziadek
Keyword(s):  
Pathogenic Mycobacterium

scholarly journals Comparative Phylogenomics of Pathogenic and Non-Pathogenic Mycobacterium

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71248 ◽  
Author(s):  
Arun N. Prasanna ◽  
Sarika Mehra
Keyword(s):  
Pathogenic Mycobacterium

scholarly journals Some South African Rubiaceae Tree Leaf Extracts Have Antimycobacterial Activity Against Pathogenic and Non-pathogenic Mycobacterium Species

2015 ◽  
Vol 29 (7) ◽  
pp. 1004-1010 ◽  
Author(s):  
Abimbola O. Aro ◽  
Jean P. Dzoyem ◽  
Tiny M. Hlokwe ◽  
Evelyn Madoroba ◽  
Jacobus N. Eloff ◽  
...  
Keyword(s):  
South African ◽  
Antimycobacterial Activity ◽  
Mycobacterium Species ◽  
Leaf Extracts ◽  
Pathogenic Mycobacterium ◽  
Tree Leaf

A Pathogenic Mycobacterium Isolated on Simple Agar Media

1985 ◽  
Vol 16 (6) ◽  
pp. 374-376 ◽  
Author(s):  
Raymond S.W. Tsang ◽  
W.H. Seto ◽  
Y.K. Leung ◽  
K. Chow ◽  
K.S. Li
Keyword(s):  
Pathogenic Mycobacterium ◽  
Agar Media

scholarly journals Direct EPR Detection of Nitric Oxide in Mice Infected with the Pathogenic Mycobacterium Mycobacterium tuberculosis

2009 ◽  
Vol 38 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Anatoly F. Vanin ◽  
Raisa P. Selitskaya ◽  
Vladimir A. Serezhenkov ◽  
Galina N. Mozhokina
Keyword(s):  
Nitric Oxide ◽  
Mycobacterium Tuberculosis ◽  
Pathogenic Mycobacterium

scholarly journals Pathogenic Mycobacterium bovis strains differ in their ability to modulate the proinflammatory activation phenotype of macrophages

2012 ◽  
Vol 12 (1) ◽  
pp. 166 ◽  
Author(s):  
Marcelle RM Andrade ◽  
Eduardo P Amaral ◽  
Simone CM Ribeiro ◽  
Fabricio M Almeida ◽  
Tanara V Peres ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Pathogenic Mycobacterium

scholarly journals Mycobacterium tuberculosis Small RNA MTS1338 Confers Pathogenic Properties to Non-Pathogenic Mycobacterium smegmatis

2021 ◽  
Vol 9 (2) ◽  
pp. 414
Author(s):  
Oksana Bychenko ◽  
Yulia Skvortsova ◽  
Rustam Ziganshin ◽  
Artem Grigorov ◽  
Leonid Aseev ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Small Rna ◽  
Mycobacterium Smegmatis ◽  
Raw 264.7 Macrophages ◽  
Pathogenic Mycobacterium ◽  
Tnf Α ◽  
Non Coding Rnas ◽  
And Control ◽  
Wall Components

Small non-coding RNAs play a key role in bacterial adaptation to various stresses. Mycobacterium tuberculosis small RNA MTS1338 is upregulated during mycobacteria infection of macrophages, suggesting its involvement in the interaction of the pathogen with the host. In this study, we explored the functional effects of MTS1338 by expressing it in non-pathogenic Mycobacterium smegmatis that lacks the MTS1338 gene. The results indicated that MTS1338 slowed the growth of the recombinant mycobacteria in culture and increased their survival in RAW 264.7 macrophages, where the MTS1338-expressing strain significantly (p < 0.05) reduced the number of mature phagolysosomes and changed the production of cytokines IL-1β, IL-6, IL-10, IL-12, TGF-β, and TNF-α compared to those of the control strain. Proteomic and secretomic profiling of recombinant and control strains revealed differential expression of proteins involved in the synthesis of main cell wall components and in the regulation of iron metabolism (ESX-3 secretion system) and response to hypoxia (furA, whiB4, phoP). These effects of MTS1338 expression are characteristic for M. tuberculosis during infection, suggesting that in pathogenic mycobacteria MTS1338 plays the role of a virulence factor supporting the residence of M. tuberculosis in the host.

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