scholarly journals Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Qingsheng Zhang ◽  
Dorna Esrafilzadeh ◽  
Jeremy M. Crook ◽  
Robert Kapsa ◽  
Elise M. Stewart ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Conductive Polymer ◽  
Prefrontal Cortical

scholarly journals Electrical Stimulation with a Conductive Polymer Promotes Neurite Outgrowth and Synaptogenesis in Primary Cortical Neurons in 3D

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Qingsheng Zhang ◽  
Stephen Beirne ◽  
Kewei Shu ◽  
Dorna Esrafilzadeh ◽  
Xu-Feng Huang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Conductive Polymer ◽  
Primary Cortical Neurons

LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons

2001 ◽  
Vol 40 (8) ◽  
pp. 992-1002 ◽  
Author(s):  
Polly Baumbarger ◽  
Mark Muhlhauser ◽  
Charles R Yang ◽  
Eric S Nisenbaum
Keyword(s):  
Ampa Receptor ◽  
Cortical Neurons ◽  
Prefrontal Cortical ◽  
Electrophysiological Studies

Neurotrophic factor-α1 modulates NGF-induced neurite outgrowth through interaction with Wnt-3a and Wnt-5a in PC12 cells and cortical neurons

2015 ◽  
Vol 68 ◽  
pp. 222-233 ◽  
Author(s):  
Prabhuanand Selvaraj ◽  
Jane S.W. Huang ◽  
Alexander Chen ◽  
Nir Skalka ◽  
Rina Rosin-Arbesfeld ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Neurotrophic Factor ◽  
Cortical Neurons

Excitation of rat prefrontal cortical neurons by dopamine: An in vitro electrophysiological study

1987 ◽  
Vol 425 (2) ◽  
pp. 263-274 ◽  
Author(s):  
Jacqueline Penit-Soria ◽  
Etienne Audinat ◽  
Francis Crepel
Keyword(s):  
Cortical Neurons ◽  
Electrophysiological Study ◽  
Prefrontal Cortical

scholarly journals A Subpopulation of Prefrontal Cortical Neurons Is Required for Social Memory

2020 ◽  
Author(s):  
Bo Xing ◽  
Nancy R. Mack ◽  
Kai-Ming Guo ◽  
Yu-Xiang Zhang ◽  
Billy Ramirez ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Social Memory ◽  
Prefrontal Cortical

scholarly journals Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons

Toxins ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 603
Author(s):  
Hyunseong Kim ◽  
Jin Young Hong ◽  
Junseon Lee ◽  
Wan-Jin Jeon ◽  
In-Hyuk Ha
Keyword(s):  
Phospholipase A2 ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Neurological Diseases ◽  
Minor Component ◽  
Underlying Mechanism ◽  
Bee Venom ◽  
Dependent Manner ◽  
Neuroprotective Effects ◽  
Wide Range

Apamin is a minor component of bee venom and is a polypeptide with 18 amino acid residues. Although apamin is considered a neurotoxic compound that blocks the potassium channel, its neuroprotective effects on neurons have been recently reported. However, there is little information about the underlying mechanism and very little is known regarding the toxicological characterization of other compounds in bee venom. Here, cultured mature cortical neurons were treated with bee venom components, including apamin, phospholipase A2, and the main component, melittin. Melittin and phospholipase A2 from bee venom caused a neurotoxic effect in dose-dependent manner, but apamin did not induce neurotoxicity in mature cortical neurons in doses of up to 10 µg/mL. Next, 1 and 10 µg/mL of apamin were applied to cultivate mature cortical neurons. Apamin accelerated neurite outgrowth and axon regeneration after laceration injury. Furthermore, apamin induced the upregulation of brain-derived neurotrophic factor and neurotrophin nerve growth factor, as well as regeneration-associated gene expression in mature cortical neurons. Due to its neurotherapeutic effects, apamin may be a promising candidate for the treatment of a wide range of neurological diseases.

scholarly journals 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons

Development ◽  
1996 ◽  
Vol 122 (2) ◽  
pp. 647-658
Author(s):  
N. Maeda ◽  
M. Noda
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Cortical Neurons ◽  
Tyrosine Phosphatase ◽  
Neuronal Cell ◽  
Morphological Differentiation ◽  
Cell Types ◽  
Thalamic Neurons ◽  
Neurite Extension ◽  
The Brain

6B4 proteoglycan/phosphacan is one of the major phosphate-buffered saline-soluble chondroitin sulfate proteoglycans of the brain. Recently, this molecule has been demonstrated to be an extracellular variant of the proteoglycan-type protein tyrosine phosphatase, PTPzeta (RPTPbeta). The influence of the 6B4 proteoglycan, adsorbed onto the substratum, on cell adhesion and neurite outgrowth was studied using dissociated neurons from the cerebral cortex and thalamus. 6B4 proteoglycan adsorbed onto plastic tissue culture dishes did not support neuronal cell adhesion, but rather exerted repulsive effects on cortical and thalamic neurons. When neurons were densely seeded on patterned substrata consisting of a grid-like structure of alternating poly-L-lysine and 6B4 proteoglycan-coated poly-L-lysine domains, they were concentrated on the poly-L-lysine domains. However, 6B4 proteoglycan did not retard the differentiation of neurons but rather promoted neurite outgrowth and development of the dendrites of cortical neurons, when neurons were sparsely seeded on poly-L-lysine-conditioned coverslips continuously coated with 6B4 proteoglycan. This effect of 6B4 proteoglycan on the neurite extension of cortical neurons was apparent even on coverslips co-coated with fibronectin or tenascin. By contrast, the neurite extension of thalamic neurons was not modified by 6B4 proteoglycan. Chondroitinase ABC or keratanase digestion of 6B4 proteoglycan did not affect its neurite outgrowth promoting activity, but a polyclonal antibody against 6B4 proteoglycan completely suppressed this activity, suggesting that a protein moiety is responsible for the activity. 6B4 proteoglycan transiently promoted tyrosine phosphorylation of an 85x10(3) Mr protein in the cortical neurons, which correlated with the induction of neurite outgrowth. These results suggest that 6B4 proteoglycan/phosphacan modulates morphogenesis and differentiation of neurons dependent on its spatiotemporal distribution and the cell types in the brain.

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