scholarly journals Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Bartosz Szczesny ◽  
Michela Marcatti ◽  
John R. Zatarain ◽  
Nadiya Druzhyna ◽  
John E. Wiktorowicz ◽  
...  
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Lung Adenocarcinoma ◽  
Chemotherapeutic Drugs ◽  
Mitochondrial Dna Repair ◽  
Cellular Bioenergetics

Hydrogen Sulfide: A Supporter of Mitochondrial DNA Repair and Cellular Bioenergetics in Lung CancerCells

2015 ◽  
Vol 87 ◽  
pp. S73
Author(s):  
Bartosz Szczesny ◽  
Michela Marcatti ◽  
Attila Brunyanszki ◽  
Mark R. Hellmich ◽  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Mitochondrial Dna Repair ◽  
Cellular Bioenergetics

Hydrogen Sulfide Is an Endogenous Stimulator of Mitochondrial DNA Repair

2014 ◽  
Vol 76 ◽  
pp. S92-S93
Author(s):  
Bartosz Szczesny ◽  
Mark E. Wood ◽  
Matthew Whiteman ◽  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Mitochondrial Dna Repair

scholarly journals Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 220
Author(s):  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Cancer Cells ◽  
Mitochondrial Fission ◽  
Cytotoxic Action ◽  
Atp Production ◽  
Mitochondrial Functions ◽  
Mitochondrial Dna Repair ◽  
Stimulation Of

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H2S as an endogenously produced mammalian gaseous transmitter. Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H2S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor—with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H2S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H2S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells.

141 Mitochondrial transcription factor a mitochondrial DNA repair

Mitochondrion ◽  
2010 ◽  
Vol 10 (2) ◽  
pp. 240
Author(s):  
Deborah L. Croteau ◽  
Anne-Cécile V. Bayne ◽  
Chandrika Canugovi ◽  
Scott Maynard ◽  
Nadja de Souza-Pinto ◽  
...  
Keyword(s):  
Dna Repair ◽  
Transcription Factor ◽  
Mitochondrial Dna ◽  
Mitochondrial Transcription ◽  
Mitochondrial Transcription Factor ◽  
Mitochondrial Dna Repair ◽  
Mitochondrial Transcription Factor A

Mitochondrial behavior during nuclear and mitochondrial DNA repair in Trypanosoma cruzi epimastigotes

2020 ◽  
Vol 219 ◽  
pp. 108016
Author(s):  
Tamires Marco Antônio Salgado Martins ◽  
Eduardo de Figueiredo Peloso ◽  
Héllida Marina Costa-Silva ◽  
Matheus Andrade Rajão ◽  
Bennet Van Houten ◽  
...  
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Trypanosoma Cruzi ◽  
Mitochondrial Dna Repair
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