Hydrogen sulfide in lung adenocarcinoma: A tumor cell survival factor, an enhancer of mitochondrial DNA repair and a cellular bioenergetic stimulator

Nitric Oxide ◽  
2015 ◽  
Vol 47 ◽  
pp. S46 ◽  
Author(s):  
Bartosz Szczesny ◽  
Attila Brunyanszki ◽  
Mark R. Hellmich ◽  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Tumor Cell ◽  
Lung Adenocarcinoma ◽  
Cell Survival ◽  
Survival Factor ◽  
Tumor Cell Survival ◽  
Mitochondrial Dna Repair ◽  
Cell Survival Factor

scholarly journals Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

2013 ◽  
Vol 73 (19) ◽  
pp. 5974-5984 ◽  
Author(s):  
Silvia Licciulli ◽  
Jacqueline L. Avila ◽  
Linda Hanlon ◽  
Scott Troutman ◽  
Matteo Cesaroni ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Lung Adenocarcinoma ◽  
Cell Survival ◽  
Tumor Cell Survival

Hydrogen Sulfide Is an Endogenous Stimulator of Mitochondrial DNA Repair

2014 ◽  
Vol 76 ◽  
pp. S92-S93
Author(s):  
Bartosz Szczesny ◽  
Mark E. Wood ◽  
Matthew Whiteman ◽  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Mitochondrial Dna Repair

scholarly journals Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 220
Author(s):  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Cancer Cells ◽  
Mitochondrial Fission ◽  
Cytotoxic Action ◽  
Atp Production ◽  
Mitochondrial Functions ◽  
Mitochondrial Dna Repair ◽  
Stimulation Of

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its cytotoxic action. However, studies conducted over the last two decades unveiled multiple biological regulatory roles of H2S as an endogenously produced mammalian gaseous transmitter. Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes. In contrast to its inhibitory (toxicological) mitochondrial effects, at lower (physiological) concentrations, H2S serves as a stimulator of electron transport in mammalian mitochondria, by acting as an electron donor—with sulfide:quinone oxidoreductase (SQR) being the immediate electron acceptor. The mitochondrial roles of H2S are significant in various cancer cells, many of which exhibit high expression and partial mitochondrial localization of various H2S producing enzymes. In addition to the stimulation of mitochondrial ATP production, the roles of endogenous H2S in cancer cells include the maintenance of mitochondrial organization (protection against mitochondrial fission) and the maintenance of mitochondrial DNA repair (via the stimulation of the assembly of mitochondrial DNA repair complexes). The current article overviews the state-of-the-art knowledge regarding the mitochondrial functions of endogenously produced H2S in cancer cells.

Hydrogen Sulfide: A Supporter of Mitochondrial DNA Repair and Cellular Bioenergetics in Lung CancerCells

2015 ◽  
Vol 87 ◽  
pp. S73
Author(s):  
Bartosz Szczesny ◽  
Michela Marcatti ◽  
Attila Brunyanszki ◽  
Mark R. Hellmich ◽  
Csaba Szabo
Keyword(s):  
Dna Repair ◽  
Mitochondrial Dna ◽  
Hydrogen Sulfide ◽  
Mitochondrial Dna Repair ◽  
Cellular Bioenergetics

scholarly journals Transglutaminase is a tumor cell and cancer stem cell survival factor

2015 ◽  
Vol 54 (10) ◽  
pp. 947-958 ◽  
Author(s):  
Richard L. Eckert ◽  
Matthew L. Fisher ◽  
Dan Grun ◽  
Gautam Adhikary ◽  
Wen Xu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Cell ◽  
Cell Survival ◽  
Survival Factor ◽  
Stem Cell Survival ◽  
Cell Survival Factor
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