scholarly journals Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Michaël R. Laurent ◽  
Geoffrey L. Hammond ◽  
Marco Blokland ◽  
Ferran Jardí ◽  
Leen Antonio ◽  
...  
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
In Vivo Validation

Effects of the antileukemic drug L-asparaginase on sex hormone-binding globulin: studies in vivo and in vitro

1989 ◽  
Vol 12 (7) ◽  
pp. 489-493 ◽  
Author(s):  
L. Bartalena ◽  
E. Martino ◽  
A. Pacchiarotti ◽  
S. Balzano ◽  
M. Falcone ◽  
...  
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

RELATION BETWEEN SEX HORMONE BINDING GLOBULIN AND D-NORGESTREL LEVELS IN PLASMA

1977 ◽  
Vol 86 (2) ◽  
pp. 430-436 ◽  
Author(s):  
Arne Victor ◽  
Erik Weiner ◽  
Elof D. B. Johansson
Keyword(s):  
Oral Contraceptives ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Treatment Cycle ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Metabolic Clearance ◽  
Hormone Binding ◽  
Metabolic Clearance Rate

ABSTRACT In order to investigate the effect of changes in sex hormone binding globulin (SHBG) levels on d-norgestrel (d-Ng) levels in plasma, the plasma levels of SHBG and d-Ng were studied during one treatment cycle in 6 women on oral contraceptives containing d-Ng and ethinyloestradiol (EOe2) and in 3 women using subcutaneous silastic rods containing d-Ng concomitantly taking EOe2 for three weeks. A significant positive correlation between the SHBG and d-Ng levels was found in 7 of the 9 subjects studied. The results provide evidence for an in vivo binding of d-Ng to SHBG, a SHBG influence on the metabolic clearance rate of d-Ng and consequently a dependence of the plasma levels of d-Ng on the SHBG concentrations in the plasma. These findings support the concept that the clinically and biochemically observed anti-oestrogenic/androgenic effects observed in women on d-Ng containing medication are due to a displacement of testosterone from SHBG by d-Ng.

A COMPARISON OF THE EFFECTS OF DANAZOL AND GESTRINONE ON TESTOSTERONE BINDING TO SEX HORMONE BINDING GLOBULIN IN VITRO AND IN VIVO

1986 ◽  
Vol 24 (5) ◽  
pp. 555-563 ◽  
Author(s):  
M. DOWSETT ◽  
K. L. FORBES ◽  
GILLIAN L. ROSE ◽  
JOANNE E. MUDGE ◽  
S. L. JEFFCOATE
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Internalization of Sex Hormone-Binding Globulin into Neurons and Brain Cells in vitro and in vivo

2007 ◽  
Vol 86 (2) ◽  
pp. 84-93 ◽  
Author(s):  
J.D. Caldwell ◽  
R.A. Shapiro ◽  
G.F. Jirikowski ◽  
F. Suleman
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Brain Cells ◽  
Hormone Binding
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