scholarly journals Polymeric nanocapsules with up-converting nanocrystals cargo make ideal fluorescent bioprobes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
U. Bazylińska ◽  
D. Wawrzyńczyk ◽  
J. Kulbacka ◽  
R. Frąckowiak ◽  
B. Cichy ◽  
...  
Keyword(s):  
Polymeric Nanocapsules ◽  
Fluorescent Bioprobes

Development and Validation of a Simple LC-UV Method to Assay Doxazosin in Polymeric Nanocapsules and Tablets

2017 ◽  
Vol 13 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Jessica Saldanha Krai ◽  
Diego Fontana de Andrade ◽  
Ruy Carlos Ruver Beck
Keyword(s):  
Polymeric Nanocapsules ◽  
Development And Validation

Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

2015 ◽  
Vol 17 (4) ◽  
Author(s):  
Katiane Roversi ◽  
Dalila M. Benvegnú ◽  
Karine Roversi ◽  
Fabíola Trevizol ◽  
Luciana T. Vey ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Lipid Core ◽  
Polymeric Nanocapsules ◽  
And Oxidative Stress

Validation of Analytical Methods for Tacrolimus Determination in Poly(ε-caprolactone) Nanocapsules and Identification of Drug Degradation Products

2021 ◽  
Vol 21 (12) ◽  
pp. 5920-5928
Author(s):  
Guilherme A. Camargo ◽  
Amanda M. Lyra ◽  
Fernanda M. Barboza ◽  
Barbara C. Fiorin ◽  
Flávio L. Beltrame ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
High Performance ◽  
Degradation Products ◽  
Multiple Reaction Monitoring ◽  
Forced Degradation ◽  
Alkaline Stress ◽  
Drug Degradation ◽  
Relative Standard ◽  
Polymeric Nanocapsules ◽  
Alkaline Conditions

The aim of this paper was to use chromatographic tools for validating an analytical method for the tacrolimus (TAC) determination in polymeric nanocapsules and for identifying the drug degradation products after alkaline stress. A rapid Ultra-High-Performance Liquid Chromatography coupled with photo-diode array (UHPLC-PDA) method was successfully performed using the following chromatographic conditions: the Shimadzu Shim-pack XR-ODS III C18 column (100 mm×2.00 mm, 2.2 μm), the mobile phase consisting of methanol and acidified ultrapure water (89:11 v/v), the flow rate of 0.55 mL·min−1, and the ultraviolet (UV) detection at 235 nm. This method was validated as per International Council for Harmonisation (ICH) guidelines. In addition, a TAC forced degradation assay was carried out after alkaline stress and its degradation products were investigated using Liquid Chromatography coupled tandem mass spectroscopy (LC-MS/MS). The calibration curve was linear in the range of 100.0–300.0 μg·mL−1 (r >0.9999). Accuracy was confirmed by the TAC recovery of 96.55 to 98.19%. Precision (intraday and interday) were demonstrated by relative standard deviation lower than 0.89% and 3.25%, respectively. Selectivity and robustness were also proved. The method developed it was successfully applied to quantify TAC from polymeric nanocapsules, showing a high loading efficiency rate (>96.47%). The main drug degradation product observed in a multiple reaction monitoring (MRM) experiment was m/z 844, confirming the susceptibility of TAC under alkaline conditions; this finding was first time described.

Polymeric nanocapsules templated on liquid cores as efficient photoreactors

RSC Advances ◽  
2016 ◽  
Vol 6 (37) ◽  
pp. 31290-31300 ◽  
Author(s):  
J. Szafraniec ◽  
J. Odrobińska ◽  
S. Zapotoczny
Keyword(s):  
Liquid Core ◽  
Polymeric Nanocapsules

Polymeric nanocapsules templated on liquid core, stabilized by graft amphiphilic polyelectrolytes were fabricated and applied as photochemical reactors.

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