scholarly journals Ultrahigh Frequency (100 MHz–300 MHz) Ultrasonic Transducers for Optical Resolution Medical Imagining

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chunlong Fei ◽  
Chi Tat Chiu ◽  
Xiaoyang Chen ◽  
Zeyu Chen ◽  
Jianguo Ma ◽  
...  
2016 ◽  
Vol 119 (9) ◽  
pp. 094103 ◽  
Author(s):  
Xiaoyang Chen ◽  
Chunlong Fei ◽  
Zeyu Chen ◽  
Ruimin Chen ◽  
Ping Yu ◽  
...  

2021 ◽  
Author(s):  
Sangnam Kim ◽  
Sunho Moon ◽  
Sunghoon Rho ◽  
Sangpil Yoon

AbstractEven though ultrahigh frequency ultrasonic transducers over 60 MHz have been used for single cell level manipulation such as intracellular delivery, acoustic tweezers, and stimulation to investigate cell phenotype and cell mechanics, no techniques have been available to measure actual acoustic radiation force (ARF) applied to target cells. Therefore, we have developed an approach to measure ARF of ultrahigh frequency ultrasonic transducers using theoretical model of the dynamics of a solid sphere in a gelatin phantom. To estimate ARF at the focus of 130 MHz transducer, we matched measured maximum displacements of a solid sphere with theoretical calculations. We selected appropriate ranges of input voltages and pulse durations for single cell applications and estimated ARF were in the range of tens of pN to nN. FRET live cell imaging was demonstrated to visualize calcium transport between cells after a target single cell was stimulated by the developed ultrasonic transducer.


2020 ◽  
Vol 14 (3) ◽  
Author(s):  
Qiang-Bing Lu ◽  
Tuo Liu ◽  
Lei Ding ◽  
Ming-Hui Lu ◽  
Jie Zhu ◽  
...  

Ultrasonics ◽  
2013 ◽  
Vol 53 (5) ◽  
pp. 1033-1038 ◽  
Author(s):  
Kwok Ho Lam ◽  
Hong Fen Ji ◽  
Fan Zheng ◽  
Wei Ren ◽  
Qifa Zhou ◽  
...  

2012 ◽  
Vol 110 (3) ◽  
pp. 881-886 ◽  
Author(s):  
Kwok Ho Lam ◽  
Hsiu-Sheng Hsu ◽  
Ying Li ◽  
Changyang Lee ◽  
Anderson Lin ◽  
...  

Micromachines ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 515 ◽  
Author(s):  
Di Li ◽  
Chunlong Fei ◽  
Qidong Zhang ◽  
Yani Li ◽  
Yintang Yang ◽  
...  

This paper describes the design of an ultrahigh frequency ultrasound system combined with tightly focused 500 MHz ultrasonic transducers and high frequency wideband low noise amplifier (LNA) integrated circuit (IC) model design. The ultrasonic transducers are designed using Aluminum nitride (AlN) piezoelectric thin film as the piezoelectric element and using silicon lens for focusing. The fabrication and characterization of silicon lens was presented in detail. Finite element simulation was used for transducer design and evaluation. A custom designed LNA circuit is presented for amplifying the ultrasound echo signal with low noise. A Common-source and Common-gate (CS-CG) combination structure with active feedback is adopted for the LNA design so that high gain and wideband performances can be achieved simultaneously. Noise and distortion cancelation mechanisms are also employed in this work to improve the noise figure (NF) and linearity. Designed by using a 0.35 μm complementary metal oxide semiconductor (CMOS) technology, the simulated power gain of the echo signal wideband amplifier is 22.5 dB at 500 MHz with a capacitance load of 1.0 pF. The simulated NF at 500 MHz is 3.62 dB.


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