scholarly journals Lanthanum induced B-to-Z transition in self-assembled Y-shaped branched DNA structure

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ashok K. Nayak ◽  
Aseem Mishra ◽  
Bhabani S. Jena ◽  
Barada K. Mishra ◽  
Umakanta Subudhi
1997 ◽  
Vol 269 (5) ◽  
pp. 647-664 ◽  
Author(s):  
Malcolm F White ◽  
Marie-Josèphe E Giraud-Panis ◽  
J.Richard G Pöhler ◽  
David M.J Lilley
Keyword(s):  

2019 ◽  
Vol 141 (48) ◽  
pp. 19032-19037 ◽  
Author(s):  
Jianbing Liu ◽  
Tiantian Wu ◽  
Xuehe Lu ◽  
Xiaohui Wu ◽  
Shaoli Liu ◽  
...  
Keyword(s):  

Nano Letters ◽  
2016 ◽  
Vol 16 (11) ◽  
pp. 6780-6786 ◽  
Author(s):  
Kosti Tapio ◽  
Jenni Leppiniemi ◽  
Boxuan Shen ◽  
Vesa P. Hytönen ◽  
Wolfgang Fritzsche ◽  
...  

1989 ◽  
Vol 86 (19) ◽  
pp. 7336-7340 ◽  
Author(s):  
J. P. Cooper ◽  
P. J. Hagerman

Nanoscale ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 195-202 ◽  
Author(s):  
S. Nahar ◽  
A. K. Nayak ◽  
A. Ghosh ◽  
U. Subudhi ◽  
S. Maiti

Simultaneous targeting of multiple miRNAs by a single self-assembled branch DNA harbouring sites for miRNA binding.


The four-way DNA junction is an important intermediate in recombination processes; it is, the substrate for different enzyme activities. In solution, the junction adopts a right-handed, antiparallel-stacked X -structure formed by the pairwise coaxial-stacking of helical arms. The stereochemistry is determined by the juxtaposition of grooves and backbones, which is optimal when the smaller included angle is 60°. The antiparallel structure has two distinct sides with major and minor groove-characteristics, respectively. The folding process requires the binding of metal cations, in the absence of which, the junction remains extended without helix-helix stacking. The geometry of the junction can be perturbed by the presence of certain base-base mispairs or phosphodiester discontinuities located at the point of strand exchange. The four-way DNA junction is selectively cleaved by a number of resolving enzymes. In a number of cases, these appear to recognize the minor groove face of the junction and are functionally divisible into activities that recognize and bind the junction, and a catalytic activity. Some possible mechanisms for the recognition of branched DNA structure are discussed.


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