scholarly journals Erratum: Corrigendum: Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yoonsu Cho ◽  
So-Youn Shin ◽  
Sungho Won ◽  
Caroline L Relton ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Mendelian Randomisation

scholarly journals Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yoonsu Cho ◽  
So-Youn Shin ◽  
Sungho Won ◽  
Caroline L Relton ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Fasting Blood Glucose ◽  
Asian Population ◽  
Population Level ◽  
Mendelian Randomisation

Abstract Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on cardiovascular risk factors, but such associations are observed mainly in men. The absence of associations of genetic variants (e.g. rs671 in ALDH2) with such risk factors in women – who drank little in these populations – provides evidence that the observations are not due to genetic pleiotropy. Here, we present a Mendelian randomisation study in a South Korean population (3,365 men and 3,787 women) that 1) provides robust evidence that alcohol consumption adversely affects several cardiovascular disease risk factors, including blood pressure, waist to hip ratio, fasting blood glucose and triglyceride levels. Alcohol also increases HDL cholesterol and lowers LDL cholesterol. Our study also 2) replicates sex differences in associations which suggests pleiotropy does not underlie the associations, 3) provides further evidence that association is not due to pleiotropy by showing null effects in male non-drinkers and 4) illustrates a way to measure population-level association where alcohol intake is stratified by sex. In conclusion, population-level instrumental variable estimation (utilizing interaction of rs671 in ALDH2 and sex as an instrument) strengthens causal inference regarding the largely adverse influence of alcohol intake on cardiovascular health in an Asian population.

Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Blood Lipids ◽  
The Other ◽  
The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

PP177-SUN DETERMINANTS OF APOB/APOA-I RATIO: OBESITY, DIET, ALCOHOL INTAKE AND CARDIOVASCULAR RISK FACTORS

2011 ◽  
Vol 6 (1) ◽  
pp. 90
Author(s):  
G. Tognon ◽  
C. Berg ◽  
K. Mehlig ◽  
D. Thelle ◽  
E. Strandhagen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake

scholarly journals Prevalence of cardiovascular risk factors among hypertensive military police officers

2011 ◽  
Vol 5 (10) ◽  
pp. 2374
Author(s):  
Adriana Arruda Barbosa ◽  
Giselle Pinheiro Lima Aires Gomes ◽  
Ivandra Mari Roieski ◽  
Elizângela Sofia Ribeiro Rodrigues ◽  
Sávia Denise Silva Carlotto Herrera
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Police Officers ◽  
Alcohol Intake ◽  
Smoking Habit ◽  
Activity Level ◽  
Military Police ◽  
Factores De Riesgo

ABSTRACTObjective: to verify the prevalence of cardiovascular risk factors in hypertensive military police officers. Method: this is a transversal, descriptive, and exploratory research, approved by the Research Ethics Committee of Centro Universitario Unirg under the Protocol 0142/2010, in which the 22 military police officers identified as hypertensive subjects underwent the assessment of vital signs and anthropometric measurements. After this, they answered to the questionnaires on physical activity level, smoking habit, pattern of alcohol intake, inventory of stress symptoms, and dietary interview. The data underwent a statistical analysis using the chi-square test with Yates' correction. Results: with regard to the body mass index (BMI), only 5% were normal. In the waist/hip ratio (WHR), it was found that 36.36% presented cardiac risk factors. In the physical activity level, 22.73% were sedentary, and 36.36% were insufficiently active. Considering the smoking habit, only 9.09% were smokers. In the pattern of alcohol intake, 4.55% fit into the zone III and 9.09% fit into the zone IV. Through the stress questionnaire it was found that 54.55% did not fit into any phase. In the feeding pattern assessment, 40.91% had the adequate number of daily meals and only 18.18% consumed adequate amounts of macronutrients. Conclusion: the cardiovascular risk factors evaluated, such as WHR, smoking habit, stress, and alcohol intake, presented a low prevalence among military police officers, however, with regard to BMI, those evaluated were mostly classified as subjects with overweight or obesity, insufficiently active or sedentary, and with a reduced number of daily meals. Descriptors: hypertension; cardiovascular diseases; prevalence.RESUMOObjetivo: verificar a prevalência dos fatores de risco cardiovasculares em policiais militares hipertensos. Método: trata-se de pesquisa transversal, descritiva e exploratória, aprovada pelo Comitê de Ética em Pesquisa do Centro Universitário Unirg sob o Protocolo n. 0142/2010, na qual os 22 policiais militares identificados como hipertensos foram submetidos à aferição dos sinais vitais e das medidas antropométricas. Após isso, responderam aos questionários sobre nível de atividade física, hábito tabagístico, padrão do uso do álcool, inventário de sintomas de stress e inquérito dietético. Os dados foram submetidos à análise estatística utilizando o teste de Qui-quadrado com correção de Yates. Resultados: em se tratando do índice de massa corpórea (IMC), apenas 5% encontrava-se dentro da normalidade. Na relação cintura-quadril (RCQ), constatou-se que 36,36% apresentavam fatores de risco cardíaco. No nível de atividade física, 22,73% eram sedentários e 36,36% insuficientemente ativos. Sobre hábito tabagístico, apenas 9,09% eram fumantes. No padrão do uso de álcool, 4,55% encontravam-se na zona III e 9,09% na zona IV. Por meio do questionário de estresse constatou-se 54,55% não estavam em nenhuma fase. Na avaliação do hábito alimentar, 40,91% faziam o número adequado de refeições diárias e apenas 18,18% alimentavam-se com quantidades adequadas de macronutrientes. Conclusão: os fatores de riscos cardiovasculares avaliados, como RCQ, hábito tabagístico, estresse e ingestão de álcool, apresentaram baixa prevalência nos policiais militares, porém, em relação ao IMC, os avaliados foram classificados, em sua maioria, com sobrepeso ou obesidade, insuficientemente ativos ou sedentários e com número reduzido de refeições diárias. Descritores: hipertensão; doenças cardiovasculares; prevalência.RESUMEN Objetivo: verificar la prevalencia de los factores de riesgo cardiovasculares en policías militares hipertensos. Método: esta investigación fue transversal, descriptiva y exploratoria y aprobado por el  Comité de Ética en Investigación del Centro Universitario Unirg bajo Protocolo nº 0142/2010, en el que 22 policías militares identificados como hipertensos se sometieron al contraste de signos vitales y a medidas antropométricas. Tras ello, respondieron a los cuestionarios sobre nivel de actividad física, hábitos tabaquistas, estándar de empleo de alcohol, inventario de síntomas de estrés y hábitos dietéticos. Los datos se sometieron a un análisis estadístico empleando el test de qui-cuadrado con corrección de Yates. Resultados: tratándose del índice de masa corporal (IMC), apenas el 5% se encontraba dentro de la normalidad. En la relación cintura-caderas (RCC), se constató que el 36,36% presentaban riesgo cardíaco. En el nivel de actividad física, el 22,73% eran sedentarios y el 36,36% insuficientemente activos. Sobre hábitos tabaquistas, apenas el 9,09% eran fumadores. En el estándar de consumo de alcohol, el 4,55% se encontraba en la zona III y el 9,09% en la zona IV. Por medio de cuestionario de estrés se constató que un 54,4% no estaba en ninguna fase. En la evaluación de hábitos alimenticios, el 40,91% efectuaba el número adecuado de comidas diarias y apenas el 18,18% se alimentaba con cantidades adecuadas de macro-nutrientes. Conclusión: los factores de riesgo cardiovasculares evaluados, como RCC, hábitos tabaquistas, estrés e consumo de alcohol, estos presentaron baja prevalencia en los policías militares, aunque en relación al IMC, los evaluados se clasificaron, en su mayoría, con sobrepeso y obesidad, insuficientemente activos o sedentarios y con número reducido de comidas diarias. Descriptores: hipertensión; enfermedades cardiovasculares; prevalencia.

scholarly journals Prevalence of cardiovascular risk factors among municipality workers in Chitradurga, South India

2019 ◽  
Vol 6 (5) ◽  
pp. 1594
Author(s):  
Nalina T. ◽  
Ghouse Phasha ◽  
Prashanth G. ◽  
Sree Devi B. K.
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
South India ◽  
Smoking History ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Life Years ◽  
History Of

Background: Cardiovascular disease (CVD) is the single largest cause for mortality and morbidity in the world. In India, non-communicable diseases (NCDs) were responsible for 53% of deaths and 44% of disability adjusted life years lost. Appropriate assessment and management of cardiovascular risk is vital to prevent fatal and non-fatal heart attacks and strokes and to improve health outcomes in individuals at high risk of cardiovascular events. Diabetes mellitus (DM) and HT are common diseases in adulthood, pre-disposing to many cardiovascular complications, posing a major public health challenge.This study aims to assess the prevalence of cardiovascular risk factors such as diabetes, HT, smoking, alcohol intake, dyslipidaemia and obesity among Municipality workers.Methods: A cross-sectional study was carried out between Jan 2019-June 2019 among 100 Municipality workers in Chitradurga, South India. Socio-demographic details and some of the risk factors such as alcohol intake and smoking history were obtained using a pre-tested, structured questionnaire. Blood pressure & waist circumference were measured by standard methods. Fasting blood sugar & lipid profile were measured.Results: Mean age of study participants was 38.03 years (SD ± 10.9). Out of the study subjects, 21% were known diabetic and 22% were known hypertensive. 34% of the participants had cholesterol level higher than the desirable level of 200 mg/dL. Around 72% had a history of alcohol consumption and 13% had a history of tobacco smoking during the last 1 month. The prevalence of overweight based on BMI (BMI >23) is higher among Municipality workers (56%) compared to the general population (35.4%).Conclusions: Burden of cardiovascular risk factors such as diabetes and HT were high among Municipality Workers of Chitradurga.

scholarly journals Determinants of behavioural and biological risk factors for cardiovascular diseases from state level STEPS survey (2017–19) in Madhya Pradesh

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10476
Author(s):  
Arun M. Kokane ◽  
Rajnish Joshi ◽  
Ashwin Kotnis ◽  
Anirban Chatterjee ◽  
Kriti Yadav ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Physical Inactivity ◽  
Alcohol Intake ◽  
Formal Education ◽  
Madhya Pradesh ◽  
Epidemiological Transition ◽  
Cvd Risk Factors ◽  
Cvd Risk

Background National and statewide assessment of cardiovascular risk factors needs to be conducted periodically in order to inform public health policy and prioritise allocation of funds, especially in LMICs. Although there have been studies from India which have explored the determinants of cardiovascular risk factors, they have mostly been from high epidemiological transition states. The present study assessed the determinants of cardiovascular (CVD) risk factors in a low epidemiological transition state (Madhya Pradesh) using the WHO STEPwise approach to surveillance (STEPS). Methods A total of 5,680 persons aged 18–69 years were selected from the state of Madhya Pradesh through multi-stage cluster random sampling. Key CVD risk factors we sought to evaluate were from behavioural (tobacco, alcohol, physical activity, diet) and biological domains (overweight or obese, Hypertension, Diabetes, and Raised serum cholesterol). Key socio-demographic factors of interest were the caste and tribe groups, and rural vs urban location, in addition to known influencers of CVD risk such as age, gender and education level Results Those belonging to the scheduled tribes were more at risk of consuming tobacco (OR 2.13 (95% CI [1.52–2.98]), and a diet with less than five servings of fruits and vegetables (OR 2.78 (95% CI [1.06–7.24]), but had had the least risk of physical inactivity (OR 0.31 (95% CI [0.02–0.54]). Residence in a rural area also reduced the odds of physical inactivity (OR 0.65 (95% CI [0.46–0.92])). Lack of formal education was a risk factor for both tobacco consumption and alcohol intake (OR 1.40 (95% CI [1.08–1.82]) for tobacco use; 1.68 (95% CI [1.14–2.49]) for alcohol intake). Those belonging to schedules tribes had much lower risk of being obese (OR 0.25; 95% CI [0.17–0.37]), but were at similar risk of all other clinical CVD risk factors as compared to other caste groups. Conclusion In the current study we explored socio-demographic determinants of behavioural and biological CVD risks, and found that in Madhya Pradesh, belonging to a scheduled tribe or living in a rural location, protects against being physically inactive or being overweight or obese. Increasing age confers a greater CVD-risk in all domains. Being a male, and lack of formal education confers a greater risk for behavioural domains, but not for most clinical risk domains. Future efforts at curbing CVDs should be therefore two pronged –a population-based strategy targeting biological risk factors, and a more focussed approach directed at those displaying risky behaviour.

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