scholarly journals Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Nanyang Yu ◽  
Si Wei ◽  
Meiying Li ◽  
Jingping Yang ◽  
Kan Li ◽  
...  
Keyword(s):  
High Throughput ◽  
Perfluorooctanoic Acid ◽  
Metabolic Profiles ◽  
Targeted Metabolomics

scholarly journals Extensive Metabolic Profiles of Leaves and Stems from the Medicinal Plant Dendrobium officinale Kimura et Migo

Metabolites ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 215 ◽  
Author(s):  
Cao ◽  
Ji ◽  
Li ◽  
Lu ◽  
Tian ◽  
...  
Keyword(s):  
Genomic Research ◽  
Dendrobium Officinale ◽  
Metabolic Profiles ◽  
Asian Countries ◽  
Targeted Metabolomics ◽  
Medicinal Species ◽  
Metabolomic Data ◽  
Metabolite Profiles ◽  
Widely Targeted Metabolomics ◽  
Metabolic Data

Dendrobium officinale Kimura et Migo is a commercially and pharmacologically highly prized species widely used in Western Asian countries. In contrast to the extensive genomic and transcriptomic resources generated in this medicinal species, detailed metabolomic data are still missing. Herein, using the widely targeted metabolomics approach, we detect 649 diverse metabolites in leaf and stem samples of D. officinale. The majority of these metabolites were organic acids, amino acids and their derivatives, nucleotides and their derivatives, and flavones. Though both organs contain similar metabolites, the metabolite profiles were quantitatively different. Stems, the organs preferentially exploited for herbal medicine, contained larger concentrations of many more metabolites than leaves. However, leaves contained higher levels of polyphenols and lipids. Overall, this study reports extensive metabolic data from leaves and stems of D. officinale, providing useful information that supports ongoing genomic research and discovery of bioactive compounds.

Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics

Metabolomics ◽  
2011 ◽  
Vol 8 (1) ◽  
pp. 133-142 ◽  
Author(s):  
Werner Römisch-Margl ◽  
Cornelia Prehn ◽  
Ralf Bogumil ◽  
Cornelia Röhring ◽  
Karsten Suhre ◽  
...  
Keyword(s):  
Sample Preparation ◽  
High Throughput ◽  
Tissue Sample ◽  
Targeted Metabolomics ◽  
Metabolite Extraction

Non-targeted metabolomics of multiple human cells revealing differential toxic effects of perfluorooctanoic acid

2021 ◽  
Vol 409 ◽  
pp. 125017
Author(s):  
Ruijia Zhang ◽  
Yao Yao ◽  
Lanyin Tu ◽  
Tiangang Luan ◽  
Baowei Chen
Keyword(s):  
Perfluorooctanoic Acid ◽  
Human Cells ◽  
Toxic Effects ◽  
Targeted Metabolomics

scholarly journals Targeted metabolomics of nonhuman primate serum after exposure to ionizing radiation: potential tools for high-throughput biodosimetry

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 51192-51202 ◽  
Author(s):  
Evan L. Pannkuk ◽  
Evagelia C. Laiakis ◽  
Simon Authier ◽  
Karen Wong ◽  
Albert J. Fornace
Keyword(s):  
Ionizing Radiation ◽  
Health Effects ◽  
High Throughput ◽  
Nonhuman Primate ◽  
Absorbed Dose ◽  
Targeted Metabolomics ◽  
Potential Health ◽  
Nuclear Event

There is a need for research to rapidly determine an individual's absorbed dose and its potential health effects after a potential radiological or nuclear event that could expose large portions of a population to ionizing radiation (IR).

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