scholarly journals Epstein Barr Virus and Mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of MS patients

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Giuseppe Mameli ◽  
Eleonora Cocco ◽  
Jessica Frau ◽  
Maria Giovanna Marrosu ◽  
Leonardo Antonio Sechi
Keyword(s):  
Cerebrospinal Fluid ◽  
Mycobacterium Avium ◽  
Epstein Barr Virus ◽  
Mycobacterium Avium Subsp ◽  
Barr Virus ◽  
Epstein Barr ◽  
Mycobacterium Avium Subsp Paratuberculosis

Are Mycobacterium avium subsp. paratuberculosis and Epstein–Barr virus triggers of multiple sclerosis in Sardinia?

2012 ◽  
Vol 18 (8) ◽  
pp. 1181-1184 ◽  
Author(s):  
Davide Cossu ◽  
Speranza Masala ◽  
Eleonora Cocco ◽  
Daniela Paccagnini ◽  
Jessica Frau ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mycobacterium Avium ◽  
Epstein Barr Virus ◽  
Mycobacterium Avium Subsp ◽  
Healthy Controls ◽  
Humoral Immune ◽  
Barr Virus ◽  
Protein Map ◽  
Epstein Barr ◽  
Mycobacterium Avium Subsp Paratuberculosis

Sardinia acts as an ideal setting for multiple sclerosis (MS) studies because its prevalence of MS is one of the highest worldwide. Several pathogens have been investigated amongst 119 Sardinian MS patients and 117 healthy controls to determine whether they might have a role in triggering MS in genetically predisposed individuals. Mycobacterium avium subsp. paratuberculosis (MAP) and Epstein Barr virus DNA were detected in 27.5% and 17.3%, respectively, of the MS patients. Moreover an extremely high humoral immune response against MAP recombinant protein MAP FprB (homologous to human myelin P0) was observed, whereas no significant results were found against Mycobacterium tuberculosis FprA and Helicobacter pylori HP986 protein.

EPSTEIN-BARR VIRUS LOAD IN CEREBROSPINAL FLUID OF PATIENTS WITH CHRONIC ACTIVE EPSTEIN-BARR VIRUS INFECTION

2008 ◽  
Vol 27 (11) ◽  
pp. 1027-1030 ◽  
Author(s):  
Shouichi Ohga ◽  
Masafumi Sanefuji ◽  
Masataka Ishimura ◽  
Akihiko Nomura ◽  
Hiroyuki Torisu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Virus Load ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis

2010 ◽  
Vol 16 (7) ◽  
pp. 883-887 ◽  
Author(s):  
Massimiliano Castellazzi ◽  
Carmine Tamborino ◽  
Alice Cani ◽  
Elena Negri ◽  
Eleonora Baldi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Neurological Disorders ◽  
Epstein Barr Virus ◽  
Serum Levels ◽  
Nuclear Antigen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Barr Virus ◽  
Epstein Barr ◽  
Multiple Sclerosis Patients

Cerebrospinal fluid and serum levels and intrathecal synthesis of anti-Epstein—Barr virus (EBV) IgG were measured by enzyme-linked immunosorbent assay in 80 relapsing—remitting multiple sclerosis patients grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Eighty patients with other inflammatory neurological disorders (OIND) and 80 patients with non-inflammatory neurological disorders (NIND) served as neurological controls. Cerebrospinal fluid concentrations were higher in OIND than in multiple sclerosis ( p < 0.0001) and NIND ( p < 0.01) for anti-viral-capsid-antigen (anti-VCA) IgG, in multiple sclerosis than in NIND ( p < 0.01) and in OIND than in NIND ( p < 0.05) for anti-EBV nuclear antigen-1 (EBNA-1) IgG. Serum levels were more elevated in OIND than in multiple sclerosis ( p < 0.05) and in MRI inactive than in MRI active multiple sclerosis ( p < 0.0001) for anti-VCA IgG, and in multiple sclerosis than in OIND and NIND ( p < 0.01) for anti-EBNA-1 IgG. Serum titres of anti-VCA and anti-EBNA-1 IgG were also positively ( p < 0.05) and inversely ( p < 0.001) correlated, respectively, with the Expanded Disability Status Scale. An intrathecal IgG production of anti-VCA and anti-EBNA-1 IgG, as indicated by Antibody Index, was present only in a limited number of multiple sclerosis patients and controls (range from 1.3 to 6.3%). These findings do not support a direct pathogenetic role of EBV-targeted humoral immune response in multiple sclerosis.

scholarly journals Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis Associated with IgM Antibodies to the Epstein-Barr Virus Viral Capsid Antigen

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Kossivi Apetse ◽  
Ludovic Breynaert ◽  
Chloe Butaud ◽  
Albert Beschet ◽  
Karine Blanc-Lasserre ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Epstein Barr Virus ◽  
Immunological Response ◽  
Neurological Deficits ◽  
Viral Capsid ◽  
Viral Agent ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Igm Antibodies ◽  
Epstein Barr

Some authors have suggested that the syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) results from an immunological response directed against a viral agent. Here we report a case of HaNDL in an immunocompetent 19-year-old male that could support this hypothesis.

Epstein-Barr virus DNA in the cerebrospinal fluid of an HIV patient with primary cerebral lymphoma

1998 ◽  
Vol 157 (4) ◽  
pp. 291-293 ◽  
Author(s):  
A. Plebani ◽  
R. Pinzani ◽  
L. Vago ◽  
P. Cinque ◽  
F. Triulzi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Epstein Barr Virus ◽  
Cerebral Lymphoma ◽  
Primary Cerebral Lymphoma ◽  
Barr Virus ◽  
Epstein Barr
Sign in / Sign up

Export Citation Format

Share Document