scholarly journals Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis Associated with IgM Antibodies to the Epstein-Barr Virus Viral Capsid Antigen

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Kossivi Apetse ◽  
Ludovic Breynaert ◽  
Chloe Butaud ◽  
Albert Beschet ◽  
Karine Blanc-Lasserre ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Epstein Barr Virus ◽  
Immunological Response ◽  
Neurological Deficits ◽  
Viral Capsid ◽  
Viral Agent ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Igm Antibodies ◽  
Epstein Barr

Some authors have suggested that the syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) results from an immunological response directed against a viral agent. Here we report a case of HaNDL in an immunocompetent 19-year-old male that could support this hypothesis.

Development of a time-resolved fluoroimmunoassay for Epstein–Barr virus viral capsid antigen IgA antibody in human serum

2015 ◽  
Vol 222 ◽  
pp. 16-21 ◽  
Author(s):  
Qian-Ni Liang ◽  
Pei-Qi Chen ◽  
Tian-Cai Liu ◽  
Jian-Wei Zhou ◽  
Juan-Juan Chen ◽  
...  
Keyword(s):  
Human Serum ◽  
Epstein Barr Virus ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Time Resolved ◽  
Barr Virus ◽  
Iga Antibody ◽  
Epstein Barr

Infectious antibodies in systemic lupus erythematosus patients

Lupus ◽  
2009 ◽  
Vol 18 (13) ◽  
pp. 1129-1135 ◽  
Author(s):  
Y. Berkun ◽  
G. Zandman-Goddard ◽  
O. Barzilai ◽  
M. Boaz ◽  
Y. Sherer ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Epstein Barr Virus ◽  
Viral Capsid ◽  
Infectious Agents ◽  
Viral Capsid Antigen ◽  
Igg Antibodies ◽  
Systemic Lupus ◽  
Early Antigen ◽  
Barr Virus ◽  
Epstein Barr

Infections can act as environmental triggers that induce or promote systemic lupus erythematosus (SLE) in genetically predisposed individuals. New technologies, developed recently, enable simultaneous assessment of multiple antibodies. Antibodies to specific infectious agents may shed light into the mechanisms of induction of SLE. The aim of this study was to investigate the prevalence of seropositivity and the titers of antibodies to bacterial, viral, and parasitic agents in SLE patients compared with non-autoimmune controls. Sera from 260 individuals (120 SLE patients and 140 controls) were tested by the BioPlex 2200 Multiplexed Immunoassay method (BioRad) for the prevalence and titers of antibodies to eight infectious agents (Epstein—Barr virus: early antigen IgG, nuclear antigen IgG, viral capsid antigen IgG and IgM, heterophile IgM; cytomegalovirus IgG and IgM; Toxoplasma gondii IgG and IgM; rubella IgG and IgM; Treponema pallidum TPr15G, TPr17G, TPr47G; herpes simplex virus type 1 and 2 IgG; hepatitis C virus and hepatitis B core antibodies. Cytomegalovirus IgM and Epstein—Barr virus early antigen IgG (but not other Epstein—Barr virus antigens) were significantly more prevalent in SLE patients than in controls. Conversely, positive titers of hepatitis B core and rubella IgG antibodies were less prevalent in the SLE patients than in controls. Other differences in titer positivity prevalence were not detected between patients and controls. The titers of the cytomegalovirus IgM, Toxoplasma IgG, Epstein—Barr virus early antigen, and viral capsid antigen IgG antibodies were significantly higher in SLE compared with controls. Our data suggest the importance of previous exposure to infectious agents in the induction and the prevention of SLE. Lupus (2009) 18, 1129—1135.

scholarly journals Cloning of the Rhesus Lymphocryptovirus Viral Capsid Antigen and Epstein-Barr Virus-Encoded Small RNA Homologues and Use in Diagnosis of Acute and Persistent Infections

2000 ◽  
Vol 38 (9) ◽  
pp. 3219-3225 ◽  
Author(s):  
Pasupuleti Rao ◽  
Hua Jiang ◽  
Fred Wang
Keyword(s):  
Small Rna ◽  
Epstein Barr Virus ◽  
Cross Reactivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Rt Pcr ◽  
Barr Virus ◽  
Peptide Elisa ◽  
Epstein Barr

Epstein-Barr virus (EBV) is the most common cause of infectious mononucleosis and is associated with the development of several human malignancies. A closely related herpesvirus in the same lymphocryptovirus (LCV) genera as EBV naturally infects rhesus monkeys and provides an important animal model for studying EBV pathogenesis. We cloned the small viral capsid antigen (sVCA) homologue from the rhesus LCV and developed a peptide enzyme-linked immunosorbent assay (ELISA) to determine whether epitopes in the rhesus LCV sVCA are a reliable indicator of rhesus LCV infection. In order to define a “gold standard” for rhesus LCV infection, we also cloned the EBV-encoded small RNA 1 (EBER1) and EBER2 homologues from rhesus LCV and developed a reverse transcription (RT)-PCR assay to detect persistent LCV infection in rhesus monkey peripheral blood lymphocytes. Animals from a conventional and a hand-reared colony were studied to compare the prevalence of rhesus LCV infection in the two groups. There was a 100% correlation between the peptide ELISA and EBER RT-PCR results for rhesus LCV infection. In addition, specificity for LCV infection and exclusion of potential cross-reactivity to the rhesus rhadinovirus sVCA homologue could be demonstrated using sera from experimentally infected animals. These studies establish two novel assays for reliable diagnosis of acute and persistent rhesus LCV infections. The rhesus LCV sVCA peptide ELISA provides a sensitive and reliable assay for routine screening, and these studies of the hand-reared colony confirm the feasibility of raising rhesus LCV-naive animals.

Primary Epstein-Barr Virus Infections in Children

PEDIATRICS ◽  
1977 ◽  
Vol 59 (1) ◽  
pp. 16-21
Author(s):  
Ciro Valent Sumaya
Keyword(s):  
Epstein Barr Virus ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Virus Infections ◽  
Early Antigen ◽  
Barr Virus ◽  
Ebv Infection ◽  
Antibody Titers ◽  
Epstein Barr ◽  
A Current

During a seroepidemiologic survey of a community, 13 (6.2%) of 209 children were found to be experiencing a current or recent primary Epstein-Barr virus (EBV) infection. The sera contained elevated antibody titers to viral capsid antigen of EBV, antibodies to early antigen (EA) of EBV, and specific IgM. The frequency of primary infections was highest in the first decade of life. The primary EBV infections were usually asymptomatic. The antibody to EA was directed predominantly to the R component. A heterophil antibody response was not detected.

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