scholarly journals Erratum: How Do the Size, Charge and Shape of Nanoparticles Affect Amyloid β Aggregation on Brain Lipid Bilayer?

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuna Kim ◽  
Ji-Hyun Park ◽  
Hyojin Lee ◽  
Jwa-Min Nam
Keyword(s):  
Lipid Bilayer ◽  
Amyloid Β ◽  
Brain Lipid ◽  
Shape Of Nanoparticles

scholarly journals How Do the Size, Charge and Shape of Nanoparticles Affect Amyloid β Aggregation on Brain Lipid Bilayer?

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuna Kim ◽  
Ji-Hyun Park ◽  
Hyojin Lee ◽  
Jwa-Min Nam
Keyword(s):  
Lipid Bilayer ◽  
Neuroblastoma Cells ◽  
Amyloid Β ◽  
Random Coil ◽  
Brain Lipid ◽  
Nanoparticle Shape ◽  
Total Brain ◽  
Aβ Aggregation ◽  
Shape Of Nanoparticles ◽  
The Brain

Abstract Here, we studied the effect of the size, shape and surface charge of Au nanoparticles (AuNPs) on amyloid beta (Aβ) aggregation on a total brain lipid-based supported lipid bilayer (brain SLB), a fluid platform that facilitates Aβ-AuNP aggregation process. We found that larger AuNPs induce large and amorphous aggregates on the brain SLB, whereas smaller AuNPs induce protofibrillar Aβ structures. Positively charged AuNPs were more strongly attracted to Aβ than negatively charged AuNPs and the stronger interactions between AuNPs and Aβ resulted in fewer β-sheets and more random coil structures. We also compared spherical AuNPs, gold nanorods (AuNRs) and gold nanocubes (AuNCs) to study the effect of nanoparticle shape on Aβ aggregation on the brain SLB. Aβ was preferentially bound to the long axis of AuNRs and fewer fibrils were formed whereas all the facets of AuNCs interacted with Aβ to produce the fibril networks. Finally, it was revealed that different nanostructures induce different cytotoxicity on neuroblastoma cells, and, overall, smaller Aβ aggregates induce higher cytotoxicity. The results offer insight into the roles of NPs and brain SLB in Aβ aggregation on the cell membrane and can facilitate the understanding of Aβ-nanostructure co-aggregation mechanism and tuning Aβ aggregate structures.

Amyloid-β Aggregation with Gold Nanoparticles on Brain Lipid Bilayer

Small ◽  
2014 ◽  
Vol 10 (9) ◽  
pp. 1779-1789 ◽  
Author(s):  
Hyojin Lee ◽  
Yuna Kim ◽  
Anna Park ◽  
Jwa-Min Nam
Keyword(s):  
Gold Nanoparticles ◽  
Lipid Bilayer ◽  
Amyloid Β ◽  
Brain Lipid

scholarly journals Amyloid-β Peptide Interaction with Lipid Bilayer Promotes Peptide Aggregation on the Surface and Modulates Lipid Behavior

2018 ◽  
Vol 114 (3) ◽  
pp. 429a-430a
Author(s):  
Jacob Usadi ◽  
Arthur Vale ◽  
Sashin Natesh ◽  
Karl Freed ◽  
Esmael Haddadian
Keyword(s):  
Lipid Bilayer ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Peptide Interaction

Amyloid β oligomerization is induced by brain lipid rafts

2006 ◽  
Vol 99 (3) ◽  
pp. 878-889 ◽  
Author(s):  
Sang-Il Kim ◽  
Jae-Sung Yi ◽  
Young-Gyu Ko
Keyword(s):  
Lipid Rafts ◽  
Amyloid Β ◽  
Brain Lipid

scholarly journals Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation

2016 ◽  
Vol 52 (5) ◽  
pp. 882-885 ◽  
Author(s):  
Kyle J. Korshavn ◽  
Anirban Bhunia ◽  
Mi Hee Lim ◽  
Ayyalusamy Ramamoorthy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lipid Bilayer ◽  
Lipid Bilayers ◽  
Amyloid Β ◽  
Neuronal Cell ◽  
Amyloid Formation ◽  
Folded Structure

Aggregation at the neuronal cell membrane's lipid bilayer surface is implicated in amyloid-β (Aβ) toxicity associated with Alzheimer's disease; however, structural and mechanistic insights into the process remain scarce.

Interactions of amyloid-β peptides on lipid bilayer studied by single molecule imaging and tracking

2018 ◽  
Vol 1860 (9) ◽  
pp. 1616-1624 ◽  
Author(s):  
Chun-Chieh Chang ◽  
Elin Edwald ◽  
Sarah Veatch ◽  
Duncan G. Steel ◽  
Ari Gafni
Keyword(s):  
Lipid Bilayer ◽  
Single Molecule ◽  
Amyloid Β ◽  
Single Molecule Imaging

scholarly journals Amyloid-β Peptide–Lipid Bilayer Interaction Investigated by Supercritical Angle Fluorescence

2019 ◽  
Vol 10 (12) ◽  
pp. 4776-4786
Author(s):  
Valentin Dubois ◽  
Diana Serrano ◽  
Stefan Seeger
Keyword(s):  
Lipid Bilayer ◽  
Amyloid Β ◽  
Amyloid Β Peptide
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