Amyloid-β Aggregation with Gold Nanoparticles on Brain Lipid Bilayer

Small ◽  
2014 ◽  
Vol 10 (9) ◽  
pp. 1779-1789 ◽  
Author(s):  
Hyojin Lee ◽  
Yuna Kim ◽  
Anna Park ◽  
Jwa-Min Nam
Keyword(s):  
Gold Nanoparticles ◽  
Lipid Bilayer ◽  
Amyloid Β ◽  
Brain Lipid

scholarly journals How Do the Size, Charge and Shape of Nanoparticles Affect Amyloid β Aggregation on Brain Lipid Bilayer?

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuna Kim ◽  
Ji-Hyun Park ◽  
Hyojin Lee ◽  
Jwa-Min Nam
Keyword(s):  
Lipid Bilayer ◽  
Neuroblastoma Cells ◽  
Amyloid Β ◽  
Random Coil ◽  
Brain Lipid ◽  
Nanoparticle Shape ◽  
Total Brain ◽  
Aβ Aggregation ◽  
Shape Of Nanoparticles ◽  
The Brain

Abstract Here, we studied the effect of the size, shape and surface charge of Au nanoparticles (AuNPs) on amyloid beta (Aβ) aggregation on a total brain lipid-based supported lipid bilayer (brain SLB), a fluid platform that facilitates Aβ-AuNP aggregation process. We found that larger AuNPs induce large and amorphous aggregates on the brain SLB, whereas smaller AuNPs induce protofibrillar Aβ structures. Positively charged AuNPs were more strongly attracted to Aβ than negatively charged AuNPs and the stronger interactions between AuNPs and Aβ resulted in fewer β-sheets and more random coil structures. We also compared spherical AuNPs, gold nanorods (AuNRs) and gold nanocubes (AuNCs) to study the effect of nanoparticle shape on Aβ aggregation on the brain SLB. Aβ was preferentially bound to the long axis of AuNRs and fewer fibrils were formed whereas all the facets of AuNCs interacted with Aβ to produce the fibril networks. Finally, it was revealed that different nanostructures induce different cytotoxicity on neuroblastoma cells, and, overall, smaller Aβ aggregates induce higher cytotoxicity. The results offer insight into the roles of NPs and brain SLB in Aβ aggregation on the cell membrane and can facilitate the understanding of Aβ-nanostructure co-aggregation mechanism and tuning Aβ aggregate structures.

scholarly journals Computational Insights into the Binding of Monolayer-Capped Gold Nanoparticles onto Amyloid-β Fibrils

2020 ◽  
Vol 11 (19) ◽  
pp. 3153-3160 ◽  
Author(s):  
Francesco Tavanti ◽  
Alfonso Pedone ◽  
Maria Cristina Menziani ◽  
Alfredo Alexander-Katz
Keyword(s):  
Gold Nanoparticles ◽  
Amyloid Β

scholarly journals Lipid Bilayer Coated Gold Nanoparticles Provide Insight Into Proteins' Conformational Changes

2009 ◽  
Vol 96 (3) ◽  
pp. 4a
Author(s):  
Stephan M. Woods ◽  
Katrice E. King ◽  
Avishek Kumar ◽  
Roberta E. Redfern ◽  
Alonzo Ross ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Lipid Bilayer ◽  
Conformational Changes ◽  
Insight Into

The effect of nocodazole on the transfection efficiency of lipid-bilayer coated gold nanoparticles

Biomaterials ◽  
2009 ◽  
Vol 30 (7) ◽  
pp. 1382-1388 ◽  
Author(s):  
Dan Li ◽  
Peicai Li ◽  
Gaiping Li ◽  
Jin Wang ◽  
Erkang Wang
Keyword(s):  
Gold Nanoparticles ◽  
Lipid Bilayer ◽  
Transfection Efficiency

scholarly journals Amyloid-β Peptide Interaction with Lipid Bilayer Promotes Peptide Aggregation on the Surface and Modulates Lipid Behavior

2018 ◽  
Vol 114 (3) ◽  
pp. 429a-430a
Author(s):  
Jacob Usadi ◽  
Arthur Vale ◽  
Sashin Natesh ◽  
Karl Freed ◽  
Esmael Haddadian
Keyword(s):  
Lipid Bilayer ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Peptide Interaction

The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation

Nanoscale ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 4107-4113 ◽  
Author(s):  
Guanbin Gao ◽  
Mingxi Zhang ◽  
Dejun Gong ◽  
Rui Chen ◽  
Xuejiao Hu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Size Effect ◽  
Amyloid Β
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