scholarly journals Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Dong-Dong Cao ◽  
Xin Liao ◽  
Wang Cheng ◽  
Yong-Liang Jiang ◽  
Wen-Jie Wang ◽  
...  
Keyword(s):  
Branchiostoma Floridae ◽  
Variable Lymphocyte Receptor

scholarly journals Recognition of the Thomsen-Friedenreich Pancarcinoma Carbohydrate Antigen by a Lamprey Variable Lymphocyte Receptor

2013 ◽  
Vol 288 (32) ◽  
pp. 23597-23606 ◽  
Author(s):  
Ming Luo ◽  
C. Alejandro Velikovsky ◽  
Xinbo Yang ◽  
Maqbool A. Siddiqui ◽  
Xia Hong ◽  
...  
Keyword(s):  
Carbohydrate Antigen ◽  
Variable Lymphocyte Receptor

Variable Lymphocyte Receptor-Based Adaptive Immunity in the Agnathan Sea Lamprey

2014 ◽  
pp. 1-16 ◽  
Author(s):  
Marion Parsons ◽  
Justin Chan ◽  
Heng Sun ◽  
Götz Ehrhardt
Keyword(s):  
Adaptive Immunity ◽  
Sea Lamprey ◽  
Variable Lymphocyte Receptor

scholarly journals Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Meghan O Altman ◽  
Jack R Bennink ◽  
Jonathan W Yewdell ◽  
Brantley R Herrin
Keyword(s):  
Influenza Virus ◽  
Animal Models ◽  
Convergent Evolution ◽  
Influenza A ◽  
Organic Molecules ◽  
Protein Antigens ◽  
Antigenic Sites ◽  
Foreign Proteins ◽  
Variable Lymphocyte Receptor ◽  
Globular Head

Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies (Abs) to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses ∼80% of the response on hemagglutinin (HA), mainly through recognition of the major antigenic sites in the HA globular head domain. Our findings predict basic conservation of Ab responses to protein antigens, strongly supporting the use of animal models for understanding human Ab responses to viruses and protein immunogens.

Immunohistochemical analysis of the distribution of molecules involved in ionic and pH regulation in the lancelet Branchiostoma floridae (Hubbs, 1922)

2018 ◽  
Vol 120 (1) ◽  
pp. 33-40
Author(s):  
Ivan Cuoghi ◽  
Clara Lazzaretti ◽  
Mauro Mandrioli ◽  
Lucrezia Mola ◽  
Aurora Pederzoli
Keyword(s):  
Ph Regulation ◽  
Immunohistochemical Analysis ◽  
Branchiostoma Floridae

scholarly journals The variable lymphocyte receptor as an antibody alternative

2018 ◽  
Vol 52 ◽  
pp. 74-79 ◽  
Author(s):  
Elizabeth A Waters ◽  
Eric V Shusta
Keyword(s):  
Variable Lymphocyte Receptor

scholarly journals Identification of a third variable lymphocyte receptor in the lamprey

2010 ◽  
Vol 107 (32) ◽  
pp. 14304-14308 ◽  
Author(s):  
J. Kasamatsu ◽  
Y. Sutoh ◽  
K. Fugo ◽  
N. Otsuka ◽  
K. Iwabuchi ◽  
...  
Keyword(s):  
Variable Lymphocyte Receptor
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