scholarly journals Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Zhenjian Zhuo ◽  
Jianyang Hu ◽  
Xiaolin Yang ◽  
Minfen Chen ◽  
Xueping Lei ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals Growth Suppression by Acute PromyelocyticLeukemia-Associated Protein PLZF Is Mediated by Repression ofc-mycExpression

2003 ◽  
Vol 23 (24) ◽  
pp. 9375-9388 ◽  
Author(s):  
Melanie J. McConnell ◽  
Nathalie Chevallier ◽  
Windy Berkofsky-Fessler ◽  
Jena M. Giltnane ◽  
Rupal B. Malani ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Target Genes ◽  
Ectopic Expression ◽  
Growth Suppression ◽  
Quiescent State ◽  
Cycle Arrest

ABSTRACT The transcriptional repressor PLZF was identified by its translocation with retinoic acid receptor alpha in t(11;17) acute promyelocytic leukemia (APL). Ectopic expression of PLZF leads to cell cycle arrest and growth suppression, while disruption of normal PLZF function is implicated in the development of APL. To clarify the function of PLZF in cell growth and survival, we used an inducible PLZF cell line in a microarray analysis to identify the target genes repressed by PLZF. One prominent gene identified was c-myc. The array analysis demonstrated that repression of c-myc by PLZF led to a reduction in c-myc-activated transcripts and an increase in c-myc-repressed transcripts. Regulation of c-myc by PLZF was shown to be both direct and reversible. An interaction between PLZF and the c-myc promoter could be detected both in vitro and in vivo. PLZF repressed the wild-type c-myc promoter in a reporter assay, dependent on the integrity of the binding site identified in vitro. PLZF binding in vivo was coincident with a decrease in RNA polymerase occupation of the c-myc promoter, indicating that repression occurred via a reduction in the initiation of transcription. Finally, expression of c-myc reversed the cell cycle arrest induced by PLZF. These data suggest that PLZF expression maintains a cell in a quiescent state by repressing c-myc expression and preventing cell cycle progression. Loss of this repression through the translocation that occurs in t(11;17) would have serious consequences for cell growth control.

scholarly journals ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis

2016 ◽  
Vol 7 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Xingjie Ma ◽  
Minlu Huang ◽  
Zhenqiang Wang ◽  
Bingya Liu ◽  
Zhenggang Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

Per2 Inhibits K562 Leukemia Cell Growth In Vitro and In Vivo Through Cell Cycle Arrest and Apoptosis Induction

2009 ◽  
Vol 16 (3) ◽  
pp. 403-411 ◽  
Author(s):  
Cheng-ming Sun ◽  
Shi-feng Huang ◽  
Jian-ming Zeng ◽  
Din-bing Liu ◽  
Qing Xiao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Leukemia Cell ◽  
Apoptosis Induction ◽  
Cycle Arrest

A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

2006 ◽  
Vol 340 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Michael B. Ujiki ◽  
Ben Milam ◽  
Xian-Zhong Ding ◽  
Alexandra B. Roginsky ◽  
M. Reza Salabat ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest

2008 ◽  
Vol 120 (3) ◽  
pp. 394-401 ◽  
Author(s):  
Shih-Chung Hsu ◽  
Chien-Chih Ou ◽  
Jhy-Wei Li ◽  
Tzu-Chao Chuang ◽  
Han-Pon Kuo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
M Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis

2017 ◽  
Vol 39 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
Chen Wang ◽  
Chenlu Liang ◽  
Weiliang Feng ◽  
Xianghou Xia ◽  
Feng Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals Cidan inhibits liver cancer cell growth by reducing COX-2 and VEGF expression and cell cycle arrest

2015 ◽  
Vol 9 (5) ◽  
pp. 1709-1718 ◽  
Author(s):  
NAN LI ◽  
DONGHAI ZHENG ◽  
JIE XUE ◽  
WEIXING GUO ◽  
JIE SHI ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Liver Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Vegf Expression ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
Cox 2

High-Polyphenol Sorghum Bran Extract Inhibits Cancer Cell Growth Through ROS Induction, Cell Cycle Arrest, and Apoptosis

2018 ◽  
Vol 21 (10) ◽  
pp. 990-998 ◽  
Author(s):  
Dmitriy Smolensky ◽  
Davina Rhodes ◽  
D. Scott McVey ◽  
Zachary Fawver ◽  
Ramasamy Perumal ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
Sorghum Bran
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