scholarly journals Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Zhanwei Wang ◽  
Harvey Risch ◽  
Lingeng Lu ◽  
Melinda L. Irwin ◽  
Susan Mayne ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Reproductive Factors ◽  
Joint Effect ◽  
Endometrial Cancer Risk ◽  
Phenotypic Features

scholarly journals Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2407 ◽  
Author(s):  
Thilo Dörk ◽  
Peter Hillemanns ◽  
Clemens Tempfer ◽  
Julius Breu ◽  
Markus C. Fleisch
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Clinical Management ◽  
Reproductive Factors ◽  
Reproductive Organs ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors ◽  
Novel Treatments ◽  
Repair Deficiency ◽  
Homologous Recombinational Repair

Endometrial cancer (EC) is the most common cancer affecting the female reproductive organs in higher-income states. Apart from reproductive factors and excess weight, genetic predisposition is increasingly recognized as a major factor in endometrial cancer risk. Endometrial cancer is genetically heterogeneous: while a subgroup of patients belongs to cancer predisposition syndromes (most notably the Lynch Syndrome) with high to intermediate lifetime risks, there are also several common genomic polymorphisms contributing to the spectrum of germline predispositions. Germline variants and somatic events may act in concert to modulate the molecular evolution of the tumor, where mismatch-repair deficiency is common in endometrioid endometrial tumors whereas homologous recombinational repair deficiency has been described for non-endometrioid endometrial tumors. In this review, we will survey the currently known genomic predispositions for endometrial cancer and discuss their relevance for clinical management in terms of counseling, screening and novel treatments.

scholarly journals Menstrual and reproductive factors and endometrial cancer risk: Results from a population-based case-control study in urban Shanghai

2003 ◽  
Vol 108 (4) ◽  
pp. 613-619 ◽  
Author(s):  
Wang-Hong Xu ◽  
Yong-Bing Xiang ◽  
Zhi-Xian Ruan ◽  
Wei Zheng ◽  
Jia-Rong Cheng ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Reproductive Factors ◽  
Population Based ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Control Study

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk

Food groups and endometrial cancer risk: a case-control study from Italy

2009 ◽  
Vol 200 (3) ◽  
pp. 293.e1-293.e7 ◽  
Author(s):  
Francesca Bravi ◽  
Lorenza Scotti ◽  
Cristina Bosetti ◽  
Antonella Zucchetto ◽  
Renato Talamini ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Food Groups ◽  
Endometrial Cancer Risk ◽  
Control Study

scholarly journals Association between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women

2012 ◽  
Vol 4 ◽  
pp. 278-283 ◽  
Author(s):  
Agnieszka Zając ◽  
Grzegorz Stachowiak ◽  
Tomasz Pertyński ◽  
Hanna Romanowicz ◽  
Jacek Wilczyński ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Mdm2 Snp309 ◽  
Endometrial Cancer Risk

scholarly journals A Common Variant at the 14q32 Endometrial Cancer Risk Locus Activates AKT1 through YY1 Binding

2016 ◽  
Vol 98 (6) ◽  
pp. 1159-1169 ◽  
Author(s):  
Jodie N. Painter ◽  
Susanne Kaufmann ◽  
Tracy A. O’Mara ◽  
Kristine M. Hillman ◽  
Haran Sivakumaran ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Common Variant ◽  
Endometrial Cancer Risk ◽  
Risk Locus
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