scholarly journals Increase in dicentric chromosome formation after a single CT scan in adults

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yu Abe ◽  
Tomisato Miura ◽  
Mitsuaki A. Yoshida ◽  
Risa Ujiie ◽  
Yumiko Kurosu ◽  
...  
Keyword(s):  
Ct Scan ◽  
Dicentric Chromosome ◽  
Chromosome Formation

scholarly journals The Role of Replication Bypass Pathways in Dicentric Chromosome Formation in Budding Yeast

Genetics ◽  
2010 ◽  
Vol 186 (4) ◽  
pp. 1161-1173 ◽  
Author(s):  
Andrew L. Paek ◽  
Hope Jones ◽  
Salma Kaochar ◽  
Ted Weinert
Keyword(s):  
Budding Yeast ◽  
Dicentric Chromosome ◽  
Chromosome Formation

scholarly journals Analysis of chromosome translocation frequency after a single CT scan in adults

2016 ◽  
Vol 57 (3) ◽  
pp. 220-226 ◽  
Author(s):  
Yu Abe ◽  
Tomisato Miura ◽  
Mitsuaki A. Yoshida ◽  
Risa Ujiie ◽  
Yumiko Kurosu ◽  
...  
Keyword(s):  
Ct Scan ◽  
Radiation Exposure ◽  
Low Dose ◽  
Chromosome Translocation ◽  
Dicentric Chromosome ◽  
Low Dose Radiation ◽  
Whole Genome Analysis ◽  
Chromosome Translocations ◽  
Before And After ◽  
Dose Radiation

Abstract We recently reported an increase in dicentric chromosome (DIC) formation after a single computed tomography (CT) scan (5.78–60.27 mSv: mean 24.24 mSv) and we recommended analysis of 2000 metaphase cells stained with Giemsa and centromere-FISH for dicentric chromosome assay (DCA) in cases of low-dose radiation exposure. In the present study, we analyzed the frequency of chromosome translocations using stored Carnoy's-fixed lymphocyte specimens from the previous study; these specimens were from 12 patients who were subject to chromosome painting of Chromosomes 1, 2 and 4. Chromosomes 1, 2 and 4 were analyzed in ∼5000 cells, which is equivalent to the whole-genome analysis of almost 2000 cells. The frequency of chromosome translocation was higher than the number of DICs formed, both before and after CT scanning. The frequency of chromosome translocations tended to be higher, but not significantly higher, in patients with a treatment history compared with patients without such a history. However, in contrast to the results for DIC formation, the frequency of translocations detected before and after the CT scan did not differ significantly. Therefore, analysis of chromosome translocation may not be a suitable assay for detecting chromosome aberrations in cases of low-dose radiation exposure from a CT scan. A significant increase in the frequency of chromosome translocations was not likely to be detected due to the high baseline before the CT scan; the high and variable frequency of translocations was probably due to multiple confounding factors in adults.

Dicentric Chromosome Formation and Epigenetics of Centromere Formation in Plants

2012 ◽  
Vol 39 (3) ◽  
pp. 125-130 ◽  
Author(s):  
Shulan Fu ◽  
Zhi Gao ◽  
James Birchler ◽  
Fangpu Han
Keyword(s):  
Dicentric Chromosome ◽  
Chromosome Formation

1596: Lymph Node Staging in Prostate Cancer by the use of 11C-CHOLIN-PET/CT Scan Imaging

2005 ◽  
Vol 173 (4S) ◽  
pp. 432-432
Author(s):  
Georg C. Bartsch ◽  
Norbert Blumstein ◽  
Ludwig J. Rinnab ◽  
Richard E. Hautmann ◽  
Peter M. Messer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Ct Scan ◽  
Lymph Node Staging ◽  
Pet Ct ◽  
Pet Ct Scan

Synchronous celiac axis and superior mesenteric artery embolism

VASA ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 495-498 ◽  
Author(s):  
Rajkovic ◽  
Zelic ◽  
Papes ◽  
Cizmek ◽  
Arslani
Keyword(s):  
Atrial Fibrillation ◽  
Small Intestine ◽  
Abdominal Pain ◽  
Ct Scan ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Abdominal Cavity ◽  
Celiac Axis ◽  
Contrast Administration ◽  
Artery Embolism

We present a case of combined celiac axis and superior mesenteric artery embolism in a 70-year-old patient that was examined in emergency department for atrial fibrillation and diffuse abdominal pain. Standard abdominal x-ray showed air in the portal vein. CT scan with contrast showed air in the lumen of the stomach and small intestine, bowel distension with wall thickening, and a free gallstone in the abdominal cavity. Massive embolism of both celiac axis and superior mesenteric artery was seen after contrast administration. On laparotomy, complete necrosis of the liver, spleen, stomach and small intestine was found. Gallbladder was gangrenous and perforated, and the gallstone had migrated into the abdominal cavity. We found free air that crackled on palpation of the veins of the gastric surface. The patient’s condition was incurable and she died of multiple organ failure a few hours after surgery. Acute visceral thromboembolism should always be excluded first if a combination of atrial fibrillation and abdominal pain exists. Determining the serum levels of d-dimers and lactate, combined with CT scan with contrast administration can, in most cases, confirm the diagnosis and lead to faster surgical intervention. It is crucial to act early on clinical suspicion and not to wait for the development of hard evidence.

Successful Endovascular Repair of a Leaking Abdominal Aortic Aneurysm under Local Anesthesia

Swiss Surgery ◽  
2001 ◽  
Vol 7 (2) ◽  
pp. 86-89 ◽  
Author(s):  
Lachat ◽  
Pfammatter ◽  
Bernard ◽  
Jaggy ◽  
Vogt ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Ct Scan ◽  
Local Anesthesia ◽  
Endovascular Repair ◽  
Anesthetic Management ◽  
High Risk Patient ◽  
Invasive Technique ◽  
Chronic Obstructive ◽  
Abdominal Aortic

Local anesthesia is a safe and less invasive anesthetic management for the endovascular approach to elective aortic aneurysm. We have successfully extended the indication of local anesthesia to a high-risk patient with leaking aneurysm and stable hemodynamics. Patient and methods: A 86 year old patient with renal insufficiency due to longstanding hypertension, coronary artery and chronic obstructive lung disease was transferred to our hospital with a leaking abdominal aortic aneurysm. Stable hemodynamics allowed to perform a fast CT scan, that confirmed the feasibility of endovascular repair. A bifurcated endograft (24mm x 12mm x 153mm) was implanted under local anesthesia. Results: The procedure was completed within 85 minutes without problems. The complete sealing of the aneurysm was confirmed by CT scan on the third postoperative day. Twenty months later, the patient is doing well and radiological control confirmed complete exclusion of the aneurysm. Discussion: The endoluminal treatment is a minimally invasive technique. It's feasibility can be rapidly assessed by CT scan. The transfemoral implantation can be performed under local anesthesia provided that hemodynamics are stable. This anesthetic management seems to be particularly advantageous for leaking abdominal aortic aneurysm since it doesn't change the hemodynamic situation in contrast to general anesthesia. Hemodynamic instability, abdominal distension or tenderness may indicate intraperitoneal rupture and conversion to open graft repair should be performed without delay.

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