scholarly journals Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Samir Attoub ◽  
Kholoud Arafat ◽  
Nasseredine Kamel Hammadi ◽  
Jan Mester ◽  
Anne-Marie Gaben
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Endothelial Cell ◽  
Cancer Cell ◽  
Human Lung ◽  
Tube Formation ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Inhibition of Human Lung Cancer Cell Proliferation and Survival by Post-Exercise Serum Is Associated with the Inhibition of Akt, mTOR, p70 S6K, and Erk1/2

Cancers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 46 ◽  
Author(s):  
Nigel Kurgan ◽  
Evelyn Tsakiridis ◽  
Rozalia Kouvelioti ◽  
Jessy Moore ◽  
Panagiota Klentrou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Post Exercise ◽  
Human Lung Cancer Cell ◽  
P70 S6k

scholarly journals Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling

2016 ◽  
Vol 12 (3) ◽  
pp. 2189-2193 ◽  
Author(s):  
Yang Yang ◽  
Aimin Zang ◽  
Youchao Jia ◽  
Yanhong Shang ◽  
Zhuoqi Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Inhibition of human lung cancer cell proliferation and survival by wine

2014 ◽  
Vol 14 (1) ◽  
pp. 6 ◽  
Author(s):  
Carly C Barron ◽  
Jessy Moore ◽  
Theodoros Tsakiridis ◽  
Gary Pickering ◽  
Evangelia Tsiani
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

Reciprocal activation of α5-nAChR and STAT3 in nicotine-induced human lung cancer cell proliferation

2017 ◽  
Vol 44 (7) ◽  
pp. 355-362 ◽  
Author(s):  
Yao Zhang ◽  
Yanfei Jia ◽  
Ping Li ◽  
Huanjie li ◽  
Dongjie Xiao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

Plant-Derived Protease Inhibitors LC-pi (Lavatera cashmeriana) Inhibit Human Lung Cancer Cell Proliferation In Vitro

2014 ◽  
Vol 67 (1) ◽  
pp. 156-166 ◽  
Author(s):  
Syed Rakashanda ◽  
Asif Khurshid Qazi ◽  
Rabiya Majeed ◽  
Syed Mubashir Andrabi ◽  
Abid Hamid ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Protease Inhibitors ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Proliferation In Vitro

An Inventive Report of Inducing Apoptosis in Non-Small Cell Lung Cancer (NSCLC) Cell Lines by Transfection of MiR-4301

2019 ◽  
Vol 19 (13) ◽  
pp. 1609-1617
Author(s):  
Abbas J. Avval ◽  
Ahmad Majd ◽  
Naghmeh Gholipour ◽  
Kambiz A. Noghabi ◽  
Anna Ohradanova-Repic ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Human Lung Cancer Cell

Background:Based on recent studies, new therapeutic strategies have been developed for cancer treatment using microRNAs (miRNAs). With this view, miRNAs manipulating techniques can be considered as novel therapeutic prospects for cancer treatment. In this study, we evaluated the expression of miR-4301 in human lung cancer cell lines and investigated its potential role in cell proliferation and tumor suppression on Non-Small Cell Lung Cancer (NSCLC) cells.Methods:We used quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) to examine the level of miR- 4301 expression in human lung cancer cell lines (A549, QU-DB) and non-malignant lung epithelial cells (HFLF-PI5). Then, we investigated the effect of miR-4301 by transfecting it into these cell lines and probing for cancer cell viability and apoptosis using the MTT assay, flow cytometry and immunofluorescence staining.Results:Our results showed that the expression level of miR-4301 was significantly reduced in human lung cancer cell lines (P<0.001). When miR-4301 was transfected in lung cancer cells, their cell proliferation was suppressed and apoptosis induced. This decline in cell survival was confirmed by the MTT assay. Transfection of miR-4301 caused an increase in early and late apoptotic cells in all lung cancer cell lines tested.Conclusion:Our findings show that miR-4301 may act as a lung cancer suppressor through targeting of proteins involved in cell proliferation and survival. For this reason, targeting miR-4301 may provide a new strategy for the diagnosis and treatment of patients with this deadly disease. This article is protected by copyright. All rights reserved.

Sign in / Sign up

Export Citation Format

Share Document