The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460

2016 ◽  
Vol 68 (7) ◽  
pp. 901-911 ◽  
Author(s):  
Xiandong Tao ◽  
Ye Ning ◽  
Xuewei Zhao ◽  
Tiewen Pan
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

An Inventive Report of Inducing Apoptosis in Non-Small Cell Lung Cancer (NSCLC) Cell Lines by Transfection of MiR-4301

2019 ◽  
Vol 19 (13) ◽  
pp. 1609-1617
Author(s):  
Abbas J. Avval ◽  
Ahmad Majd ◽  
Naghmeh Gholipour ◽  
Kambiz A. Noghabi ◽  
Anna Ohradanova-Repic ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Human Lung Cancer Cell

Background:Based on recent studies, new therapeutic strategies have been developed for cancer treatment using microRNAs (miRNAs). With this view, miRNAs manipulating techniques can be considered as novel therapeutic prospects for cancer treatment. In this study, we evaluated the expression of miR-4301 in human lung cancer cell lines and investigated its potential role in cell proliferation and tumor suppression on Non-Small Cell Lung Cancer (NSCLC) cells.Methods:We used quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) to examine the level of miR- 4301 expression in human lung cancer cell lines (A549, QU-DB) and non-malignant lung epithelial cells (HFLF-PI5). Then, we investigated the effect of miR-4301 by transfecting it into these cell lines and probing for cancer cell viability and apoptosis using the MTT assay, flow cytometry and immunofluorescence staining.Results:Our results showed that the expression level of miR-4301 was significantly reduced in human lung cancer cell lines (P<0.001). When miR-4301 was transfected in lung cancer cells, their cell proliferation was suppressed and apoptosis induced. This decline in cell survival was confirmed by the MTT assay. Transfection of miR-4301 caused an increase in early and late apoptotic cells in all lung cancer cell lines tested.Conclusion:Our findings show that miR-4301 may act as a lung cancer suppressor through targeting of proteins involved in cell proliferation and survival. For this reason, targeting miR-4301 may provide a new strategy for the diagnosis and treatment of patients with this deadly disease. This article is protected by copyright. All rights reserved.

scholarly journals Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom

Toxins ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 38 ◽  
Author(s):  
Irasema Oroz-Parra ◽  
Mario Navarro ◽  
Karla Cervantes-Luevano ◽  
Carolina Álvarez-Delgado ◽  
Guy Salvesen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Synthetic Peptide ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell

scholarly journals Glutathione and related enzyme activity in human lung cancer cell lines

1988 ◽  
Vol 58 (4) ◽  
pp. 437-440 ◽  
Author(s):  
J Carmichael ◽  
JB Mitchell ◽  
N Friedman ◽  
AF Gazdar ◽  
A Russo
Keyword(s):  
Lung Cancer ◽  
Enzyme Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Related Enzyme

Activation of the NF-kappaB p50/p65 Complex in Human Lung Cancer Cell Lines

1999 ◽  
Vol 46 (2) ◽  
pp. 185
Author(s):  
Hyung Seok Choi ◽  
Chul Gyu Yoo ◽  
Choon Taek Lee ◽  
Young Whan Kim ◽  
Sung Koo Han ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Nf Kappab
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