scholarly journals Investigation of multipotent postnatal stem cells from human maxillary sinus membrane

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
JunBing Guo ◽  
JunQuan Weng ◽  
Qiong Rong ◽  
Xing Zhang ◽  
ShuangXi Zhu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Maxillary Sinus ◽  
Sinus Membrane

scholarly journals Lnc-NTF3-5 promotes osteogenic differentiation of maxillary sinus membrane stem cells via sponging miR-93-3p

2017 ◽  
Vol 20 (2) ◽  
pp. 110-121 ◽  
Author(s):  
Wei Peng ◽  
Shuang-Xi Zhu ◽  
Jin Wang ◽  
Li-Li Chen ◽  
Jun-Quan Weng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Maxillary Sinus ◽  
Sinus Membrane

Mesenchymal stem cells with osteogenic potential in human maxillary sinus membrane: an in vitro study

2016 ◽  
Vol 21 (5) ◽  
pp. 1599-1609 ◽  
Author(s):  
Antoine Berbéri ◽  
Fatima Al-Nemer ◽  
Eva Hamade ◽  
Ziad Noujeim ◽  
Bassam Badran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Maxillary Sinus ◽  
In Vitro Study ◽  
Vitro Study ◽  
Osteogenic Potential ◽  
Sinus Membrane

scholarly journals Hsa_circRNA_33287 promotes the osteogenic differentiation of maxillary sinus membrane stem cells via miR-214-3p/Runx3

2019 ◽  
Vol 109 ◽  
pp. 1709-1717 ◽  
Author(s):  
Wei Peng ◽  
Shuangxi Zhu ◽  
Junlan Chen ◽  
Jin Wang ◽  
Qiong Rong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Maxillary Sinus ◽  
Sinus Membrane

miR-27b-3p Suppressed Osteogenic Differentiation of Maxillary Sinus Membrane Stem Cells by Targeting Sp7

2017 ◽  
Vol 26 (4) ◽  
pp. 492-499 ◽  
Author(s):  
Wei Peng ◽  
Shuangxi Zhu ◽  
Xiang Li ◽  
Junquan Weng ◽  
Songling Chen
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Maxillary Sinus ◽  
Sinus Membrane

scholarly journals Stiffness Regulates the Morphology, Adhesion, Proliferation, and Osteogenic Differentiation of Maxillary Schneiderian Sinus Membrane-Derived Stem Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Yiping Liu ◽  
Jia Wang ◽  
Peisong Zhai ◽  
Sicong Ren ◽  
Zhanqi Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Maxillary Sinus ◽  
Cell Fate ◽  
Osteogenic Potential ◽  
Future Research ◽  
Sinus Augmentation ◽  
Differentiation Potential ◽  
Maxillary Sinus Augmentation ◽  
Sinus Membrane

Recent studies, which aim to optimize maxillary sinus augmentation, have paid significant attention exploring osteogenic potential of maxillary Schneiderian sinus membrane-derived cells (MSSM-derived cells). However, it remains unclear that how MSSM-derived cells could respond to niche’s biomechanical properties. Herein, this study investigated the possible effects of substrate stiffness on rMSSM-derived stem cell fate. Initially, rMSSM-derived stem cells with multiple differentiation potential were successfully obtained. We then fabricated polyacrylamide substrates with varied stiffness ranging from 13 to 68 kPa to modulate the mechanical environment of rMSSM-derived stem cells. A larger cell spreading area and increased proliferation of rMSSM-derived stem cells were found on the stiffer substrates. Similarly, cells became more adhesive as their stiffness increased. Furthermore, the higher stiffness facilitated osteogenic differentiation of rMSSM-derived stem cells. Overall, our results indicated that increase in stiffness could mediate behaviors of rMSSM-derived stem cells, which may serve as a guide in future research to design novel biomaterials for maxillary sinus augmentation.

scholarly journals Promoting effect of rapamycin on osteogenic differentiation of maxillary sinus membrane stem cells

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11513
Author(s):  
Yanjun Lin ◽  
Min Zhang ◽  
Lin Zhou ◽  
Xuxi Chen ◽  
Jiang Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Maxillary Sinus ◽  
Promoting Effect ◽  
Alizarin Red ◽  
Real Time Quantitative Pcr ◽  
Alp Activity ◽  
Transmission Electron ◽  
Sinus Membrane

Background Stem cells located in the maxillary sinus membrane can differentiate into osteocytes. Our study aimed to evaluate the effect of rapamycin (RAPA) on the osteogenic differentiation of maxillary sinus membrane stem cells (MSMSCs). Methods Colony-forming unit assay, immunophenotype identification assay, and multi-differentiation assay confirmed characteristics of MSMSCs obtained from SD rats. Transmission electron microscopy (TEM) and flow cytometry (FCM) identified the initial autophagic level of MSMSCs induced by RAPA. Real-time quantitative PCR (qPCR) evaluated subsequent autophagic levels and osteogenic differentiation. Alkaline phosphatase (ALP) activity assay and alizarin red staining (ARS) evaluated subsequent osteogenic differentiation. We performed a histological examination to clarify in vivo osteogenesis with ectopic bone mass from BALB/c nude mice. Results MSMSCs possessed an active proliferation and multi-differentiation capacity, showing a phenotype of mesenchymal stem cells. The autophagic level increased with increasing RAPA (0, 10, 100, 1,000 nM) and decreased over time. ALP activity and calcium nodules forming in four RAPA-treated groups on three-time points (7, 14, 21 d) showed significant differences. Col1a1, Runx2, and Spp1 expressed most in 100 nM RAPA group on 7 and 14 d. Osteogenesis-related genes except for Ibsp expression between four groups tended to be consistent on 21 d. 100 nM and 10 nM RAPA-treated groups showed more bone formation in vivo. Conclusion RAPA can promote osteogenic differentiation of MSMSCs, indicating a possible relationship between osteogenic differentiation and autophagy.

scholarly journals PRF-Solution in Large Sinus Membrane Perforation with Simultaneous Implant Placement-Micro CT and Histological Analysis

Membranes ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 438
Author(s):  
Horia Mihail Barbu ◽  
Stefania Andrada Iancu ◽  
Violeta Hancu ◽  
Daniel Referendaru ◽  
Joseph Nissan ◽  
...  
Keyword(s):  
Maxillary Sinus ◽  
Micro Ct ◽  
Implant Placement ◽  
Membrane Perforation ◽  
Sinus Floor Augmentation ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
The Mean ◽  
Maxillary Sinus Floor Augmentation ◽  
Sinus Membrane

Background: The purpose of the study was to analyze the efficacy of platelet-rich fibrin (PRF) as a single augmentation material for complicated cases of maxillary sinus floor elevation, resulting from membrane perforation or previous infections. Methods: Implant insertion in the posterior region of the maxilla was simultaneously performed with maxillary sinus floor augmentation. Schneiderian membrane elevation can be accompanied by extremely serious sinus membrane perforation, due to accidental tearing or intended incision for mucocele removal. PRFs were placed in the sinus cavity both for membrane sealing and sinus floor grafting. Radiological, histological and micro-CT analyses were performed. Implant survival was assessed every 6 months for 1 to 4 years, with a mean follow up of 1.8 years, after prosthetic loading. Radiological examinations were performed on CBCT at 9 and 12 and 36 months postoperatively and revealed improved degrees of radiopacity. Results: 19 implants were simultaneously placed in the course of nine maxillary sinus floor augmentation surgeries, with successful outcomes in terms of bone grafting and implant integration. New bone formation was evidenced 12 months postoperatively on radiological examination, micro-CT analysis, and histological analysis of a harvested bone segment from the augmented maxillary sinus. The mean gain in bone height of the sinus floor augmentation was 6.43 mm, with a maximum of 9 mm. The mean amount of vital bone obtained from histologic assessment was 52.30%, while bone volume/tissue volume ratio in micro-CT 3D had a mean of 50.32%. Conclusions: PRF may be considered as an alternative treatment for a single surgery of sinus augmentation with simultaneous implant placement, even in complicated cases with significant sinus membrane tearing.

scholarly journals Implant Placement after Closure of Oroantral Communication by Sinus Bone Graft Using a Collagen Barrier Membrane in the Shape of a Pouch: A Case Report and Review of the Literature

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 626
Author(s):  
Jae-Ha Baek ◽  
Byung-Ock Kim ◽  
Won-Pyo Lee
Keyword(s):  
Bone Graft ◽  
Maxillary Sinus ◽  
Maxillary Sinusitis ◽  
Collagen Membrane ◽  
Implant Placement ◽  
Barrier Membrane ◽  
Membrane Perforation ◽  
Oroantral Communication ◽  
Sinus Membrane ◽  
Posterior Area

Oro-antral communication (OAC) acts as a pathway for bacteria between the maxillary sinus and oral cavity, and is a common complication after the removal of a dental implant or extraction of a tooth from the maxillary posterior area. In the case of an untreated OAC, oro-antral fistula develops and becomes epithelialized. We aimed to introduce a treatment for OAC closure via a sinus bone grafting procedure using bone tacks and a collagen membrane with an allograft. The procedure was performed by applying an absorbable membrane made in pouch form. This membrane acted as a barrier for closing the large sinus membrane perforation. Bone tacks were used to fix the membranes. Subsequently, the maxillary sinus was filled with the allograft, and the absorbable membrane was reapplied. Primary closure was achieved by performing a periosteum-releasing incision for a tension-free suture. After 6 months, sufficient bone dimensions were gained without any occurrence of maxillary sinusitis or recurrence of OAC. Additional bone grafts and implantation could be performed to rehabilitate the maxillary posterior area. We conclude that this technique might be a useful treatment for reconstructing the maxillary posterior area with simultaneous sinus bone graft and OAC closure.

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