scholarly journals Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Hiroshi Ochiai ◽  
Takeshi Sugawara ◽  
Tetsushi Sakuma ◽  
Takashi Yamamoto
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Promoter Activation ◽  
Expression Variability ◽  
Nanog Expression

scholarly journals Correction: Perfluorooctane Sulfonate Disturbs Nanog Expression through miR-490-3p in Mouse Embryonic Stem Cells

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0221486
Author(s):  
Bo Xu ◽  
Xiaojiao Chen ◽  
Zhilei Mao ◽  
Minjian Chen ◽  
Xiumei Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Perfluorooctane Sulfonate ◽  
Mouse Embryonic Stem Cells ◽  
Nanog Expression

scholarly journals BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos

2014 ◽  
Vol 21 (12) ◽  
pp. 1950-1960 ◽  
Author(s):  
W Liu ◽  
P Stein ◽  
X Cheng ◽  
W Yang ◽  
N-Y Shao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Preimplantation Embryos ◽  
Nanog Expression

scholarly journals Inhibition of β-catenin–TCF1 interaction delays differentiation of mouse embryonic stem cells

2015 ◽  
Vol 211 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Sujash S. Chatterjee ◽  
Abil Saj ◽  
Tenzin Gocha ◽  
Matthew Murphy ◽  
Foster C. Gonsalves ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Protein Interactions ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Protein Protein Interactions ◽  
Nanog Expression ◽  
Context Specific

The ability of mouse embryonic stem cells (mESCs) to self-renew or differentiate into various cell lineages is regulated by signaling pathways and a core pluripotency transcriptional network (PTN) comprising Nanog, Oct4, and Sox2. The Wnt/β-catenin pathway promotes pluripotency by alleviating T cell factor TCF3-mediated repression of the PTN. However, it has remained unclear how β-catenin’s function as a transcriptional activator with TCF1 influences mESC fate. Here, we show that TCF1-mediated transcription is up-regulated in differentiating mESCs and that chemical inhibition of β-catenin/TCF1 interaction improves long-term self-renewal and enhances functional pluripotency. Genetic loss of TCF1 inhibited differentiation by delaying exit from pluripotency and conferred a transcriptional profile strikingly reminiscent of self-renewing mESCs with high Nanog expression. Together, our data suggest that β-catenin’s function in regulating mESCs is highly context specific and that its interaction with TCF1 promotes differentiation, further highlighting the need for understanding how its individual protein–protein interactions drive stem cell fate.

scholarly journals SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

2008 ◽  
Vol 2 (3) ◽  
pp. 241-251 ◽  
Author(s):  
Myung-Kwan Han ◽  
Eun-Kyung Song ◽  
Ying Guo ◽  
Xuan Ou ◽  
Charlie Mantel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Subcellular Localization ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Nanog Expression

scholarly journals E-cadherin and, in Its Absence, N-cadherin Promotes Nanog Expression in Mouse Embryonic Stem Cells via STAT3 Phosphorylation

Stem Cells ◽  
2012 ◽  
Vol 30 (9) ◽  
pp. 1842-1851 ◽  
Author(s):  
Kate Hawkins ◽  
Lisa Mohamet ◽  
Sarah Ritson ◽  
Catherine L. R. Merry ◽  
Christopher M. Ward
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Nanog Expression ◽  
Stat3 Phosphorylation ◽  
E Cadherin

scholarly journals Perfluorooctane Sulfonate Disturbs Nanog Expression through miR-490-3p in Mouse Embryonic Stem Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e74968 ◽  
Author(s):  
Bo Xu ◽  
Xiaojiao Chen ◽  
Zhilei Mao ◽  
Minjian Chen ◽  
Xiumei Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Perfluorooctane Sulfonate ◽  
Mouse Embryonic Stem Cells ◽  
Nanog Expression

scholarly journals Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells

Stem Cells ◽  
2015 ◽  
Vol 33 (3) ◽  
pp. 699-712 ◽  
Author(s):  
Kamil R. Kranc ◽  
Daniel V. Oliveira ◽  
Alejandro Armesilla-Diaz ◽  
Ivette Pacheco-Leyva ◽  
Ana Catarina Matias ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Self Renewal ◽  
Nanog Expression
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