scholarly journals Dermcidin isoform-2 induced nullification of the effect of acetyl salicylic acid in platelet aggregation in acute myocardial infarction

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Sarbashri Bank ◽  
Pradipta Jana ◽  
Smarajit Maiti ◽  
Santanu Guha ◽  
A. K. Sinha
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Salicylic Acid ◽  
Platelet Aggregation ◽  
Acetyl Salicylic Acid

The Quantitation of Platelet Aggregation Induced by Four Compounds: A Study in Relation to Myocardial Infarction

1966 ◽  
Vol 16 (03/04) ◽  
pp. 752-767 ◽  
Author(s):  
J. R O’Brien ◽  
F. C Path ◽  
Joan B. Heywood ◽  
J. A Heady
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Aggregation ◽  
Platelet Rich Plasma ◽  
Myocardial Infarct ◽  
Control Groups ◽  
The Mean ◽  
Platelet Shape

SummaryMethods for measuring and comparing day to day differences in the response of platelet aggregation in platelet-rich plasma to added ADP, 5-H.T., adrenaline and collagen are reported. Platelet aggregation induced by ADP, 5-H.T. and adrenaline was studied in patients with acute myocardial infarction and in others 3 months to 5 years after an infarct; some were receiving anti-coagulants and others not: these three groups were compared with three control groups. The mean platelet shape was rounder and the response to ADP and to 5-H.T. and one parameter of the response to adrenaline was significantly greater in all groups of patients with myocardial infarct taken together than in the controls. The platelet-rich plasma from patients with recent infarction were most responsive to ADP and 5-H.T. immediately after the infarct. Anti-coagulants had no effect on these tests. However, there was wide variation within the individuals and much overlap between groups, and these tests can only reliably distinguish between groups and not between individuals. The significance of these findings is discussed.

Product licences and devious promotion

1990 ◽  
Vol 28 (5) ◽  
pp. 20-20
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Aggregation ◽  
Unstable Angina ◽  
Platelet Aggregation Inhibitor ◽  
Aggregation Inhibitor

Platet 300 Cleartab (Nicholas) is an effervescent buffered aspirin formulation which the maker has described as “a new cardiovascular-specific presentation of aspirin “and” the only platelet aggregation inhibitor to be licensed for use following acute myocardial infarction, or in patients with unstable angina, to reduce the risk of infarction”.

Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction

1998 ◽  
Vol 136 (3) ◽  
pp. 398-405 ◽  
Author(s):  
Victor L. Serebruany ◽  
Paul A. Gurbel ◽  
Andrew R. Shustov ◽  
E.Magnus Ohman ◽  
Eric J. Topol
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Aggregation ◽  
Receptor Expression ◽  
Surface Receptor ◽  
Major Surface

Curious Case of Profound Thrombocytopenia in a Pregnant Woman

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 4944-4944 ◽  
Author(s):  
Prabhsimranjot Singh ◽  
Makardhwaj S Shrivastava ◽  
Daniel Benasher ◽  
Audrik Perez ◽  
Philip Rubin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Cell Count ◽  
Conflicts Of Interest ◽  
Ammonium Oxalate ◽  
Clinical Manifestations ◽  
Sodium Oxalate ◽  
Clin Pathol

Abstract Introduction: Pseudo-thrombocytopenia (PTCP) is a benign artifact which generates anxiety in the patients and physicians resulting in unnecessary investigations. We report a case with profound artefactual thrombocytopenia. Case: A 31-years-old female in 38th week of gestation was referred to hematology clinic for evaluation of a platelet count of 48x109/L. A month ago platelet count was 102x109/L. She denied any symptoms. Examination was normal with no ecchymosis or petechiae. Laboratory work showed a white cell count of 11.2x109/L, hemoglobin 10.3g/L, platelet count 8x109/L and no hemolysis. Peripheral blood smear showed numerous platelet clumps (Figure 1). Estimated manual platelet count was 200x109/L. To our surprise clumps and low machine count were seen in samples drawn in sodium citrate and heparin tubes as well. Discussion: Ethylenediaminetetra-acetic acid (EDTA) dependent PTCP is a rare phenomenon with incidence of 0.09%-0.21% in general population (1). It is present in healthy subjects (2), severely ill patients with sepsis (3), autoimmune, neoplastic and liver diseases (4). PTCP may persist for 15-20 years without any clinical manifestations (5). Platelet aggregation in PTCP is due to anti-platelet antibody mediated in-vitro activation via GPIIb receptors (6). Antibodies may be IgG, IgA or IgM (5). It may be seen in samples drawn in citrate (5) heparin (7) and sodium-oxalate (8). One should suspect PTCP when there is fall in platelet count (usually <100x109/L), time-dependent spurious elevation of white cells(9), a normal mean platelet volume (4) or microscopic detection of platelet aggregates (1) in a patient without clinical manifestations. There is a rare report that addition of amikacin could inhibit and dissociate pseudo platelet aggregation in multianticoagulant-dependent pseudo-thrombocytopenia and EDTA-induced pseudo-thrombocytopenia (10). Early identifications is extremely essential when therapeutic decision making hinges on platelet count viz. management of acute myocardial infarction (11).Use of samples at 37°C (2), ammonium oxalate (5, 7), addition of amikacin and peripheral smear review may help in complicated cases. References: 1. Yoneyama A, Nakahara K. [EDTA-dependent pseudothrombocytopenia--differentiation from true thrombocytopenia]. Nihon Rinsho. 2003;61(4):569-74. 2. Lippi G, Plebani M. EDTA-dependent pseudothrombocytopenia: further insights and recommendations for prevention of a clinically threatening artifact. Clin Chem Lab Med. 2012;50(8):1281-5. 3. Mori M, Kudo H, Yoshitake S, Ito K, Shinguu C, Noguchi T. Transient EDTA-dependent pseudothrombocytopenia in a patient with sepsis. Intensive Care Med. 2000;26(2):218-20. 4. Berkman N, Michaeli Y, Or R, Eldor A. EDTA-dependent pseudothrombocytopenia: a clinical study of 18 patients and a review of the literature. Am J Hematol. 1991;36(3):195-201. 5. Bizzaro N. EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up. Am J Hematol. 1995;50(2):103-9. 6. Fiorin F, Steffan A, Pradella P, Bizzaro N, Potenza R, De Angelis V. IgG platelet antibodies in EDTA-dependent pseudothrombocytopenia bind to platelet membrane glycoprotein IIb. Am J Clin Pathol. 1998;110(2):178-83. 7. Zandecki M, Genevieve F, Gerard J, Godon A. Spurious counts and spurious results on haematology analysers: a review. Part I: platelets. International Journal of Laboratory Hematology. 2007;29(1):4-20. 8. Schrezenmeier H, Muller H, Gunsilius E, Heimpel H, Seifried E. Anticoagulant-induced pseudothrombocytopenia and pseudoleucocytosis. Thromb Haemost. 1995;73(3):506-13. 9. Xiao Y, Xu Y. Concomitant spuriously elevated white blood cell count, a previously underestimated phenomenon in EDTA-dependent pseudothrombocytopenia. Platelets. 2015;26(7):627-31. 10. Zhou X, Wu X, Deng W, Li J, Luo W. Amikacin can be added to blood to reduce the fall in platelet count. Am J Clin Pathol. 2011 Oct;136(4):646-52. 11. Kocum TH, Katircibasi TM, Sezgin AT, Atalay H. An unusual cause of mismanagement in an acute myocardial infarction case: pseudothrombocytopenia. Am J Emerg Med. 2008;26(6):740 e1-2. Figure 1 Platelet Clumps- Magnification 60X Oil Figure 1. Platelet Clumps- Magnification 60X Oil Disclosures No relevant conflicts of interest to declare.

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