scholarly journals Dopamine D1 and D4 Receptor Subtypes Differentially Modulate Recurrent Excitatory Synapses in Prefrontal Cortical Pyramidal Neurons

2005 ◽  
Vol 31 (2) ◽  
pp. 318-338 ◽  
Author(s):  
Shao-Pii Onn ◽  
Xiao-Bin Wang ◽  
Min Lin ◽  
Anthony A Grace
Keyword(s):  
Pyramidal Neurons ◽  
Receptor Subtypes ◽  
Excitatory Synapses ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons ◽  
D4 Receptor

scholarly journals Delayed Effects of Corticosterone on Slow After-Hyperpolarization Potentials in Mouse Hippocampal versus Prefrontal Cortical Pyramidal Neurons

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99208 ◽  
Author(s):  
Anup G. Pillai ◽  
Marloes J. A. G. Henckens ◽  
Guillén Fernández ◽  
Marian Joëls
Keyword(s):  
Pyramidal Neurons ◽  
Delayed Effects ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons

scholarly journals Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity

2020 ◽  
Author(s):  
Chiayu Q. Chiu ◽  
Thomas M. Morse ◽  
Francesca Nani ◽  
Frederic Knoflach ◽  
Maria-Clemencia Hernandez ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Neuronal Excitability ◽  
Pyramidal Neurons ◽  
Calcium Influx ◽  
Brain Activity ◽  
Receptor Subtypes ◽  
Short Term ◽  
Dendritic Membrane ◽  
Cortical Pyramidal Neurons ◽  
Gabaergic Activity

SummaryBrain activity is highly regulated by GABAergic activity, which acts via GABAARs to suppress somatic spike generation as well as dendritic synaptic integration and calcium signaling. Tonic GABAergic conductances mediated by distinct receptor subtypes can also inhibit neuronal excitability and spike output, though the consequences for dendritic calcium signaling are unclear. Here, we use 2-photon calcium imaging in cortical pyramidal neurons and computational modeling to show that low affinity GABAARs containing an α5 subunit mediate a tonic hyperpolarization of the dendritic membrane potential, resulting in deinactivation of voltage-gated calcium channels and a paradoxical boosting of action potential-evoked calcium influx. We also find that GABAergic enhancement of calcium signaling modulates short-term synaptic plasticity, augmenting depolarization-induced suppression of inhibition. These results demonstrate a novel role for GABA in the control of dendritic activity and suggest a mechanism for differential modulation of electrical and biochemical signaling.

scholarly journals Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons

Cell Reports ◽  
2021 ◽  
Vol 37 (6) ◽  
pp. 109972
Author(s):  
Joshua B. Melander ◽  
Aran Nayebi ◽  
Bart C. Jongbloets ◽  
Dale A. Fortin ◽  
Maozhen Qin ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Excitatory Synapses ◽  
Cortical Pyramidal Neurons

Postsynaptic excitation of prefrontal cortical pyramidal neurons by hypocretin-1/orexin a through the inhibition of potassium currents

2005 ◽  
Vol 82 (5) ◽  
pp. 729-736 ◽  
Author(s):  
Jianxia Xia ◽  
Xiaowei Chen ◽  
Chenghui Song ◽  
Jianning Ye ◽  
Zhengping Yu ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Potassium Currents ◽  
Orexin A ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons ◽  
Hypocretin 1
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