Faculty Opinions recommendation of Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons.

2001 ◽  
Author(s):  
Randall C O'Reilly
Keyword(s):  
Pyramidal Neurons ◽  
Gabaergic Inhibition ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons ◽  
Dopamine Modulation

scholarly journals Bidirectional Dopamine Modulation of GABAergic Inhibition in Prefrontal Cortical Pyramidal Neurons

2001 ◽  
Vol 21 (10) ◽  
pp. 3628-3638 ◽  
Author(s):  
Jeremy K. Seamans ◽  
Natalia Gorelova ◽  
Daniel Durstewitz ◽  
Charles R. Yang
Keyword(s):  
Pyramidal Neurons ◽  
Gabaergic Inhibition ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons ◽  
Dopamine Modulation

Altered Neuronal Circuitry

2014 ◽  
Author(s):  
Michael S. Levine ◽  
Elizabeth A. Wang ◽  
Jane Y. Chen ◽  
Carlos Cepeda ◽  
Véronique M. André
Keyword(s):  
Mouse Models ◽  
Pyramidal Neurons ◽  
Therapeutic Interventions ◽  
Disease Stage ◽  
Medium Spiny Neurons ◽  
Behavioral Alterations ◽  
Spiny Neurons ◽  
Cortical Pyramidal Neurons ◽  
Late Stages ◽  
Dopamine Modulation

In mouse models of Huntington’s disease (HD), synaptic alterations in the cerebral cortex and striatum are present before overt behavioral symptoms and cell death. Similarly, in HD patients, it is now widely accepted that early deficits can occur in the absence of neural atrophy or overt motor symptoms. In addition, hyperkinetic movements seen in early stages are followed by hypokinesis in the late stages, indicating that different processes may be affected. In mouse models, such behavioral alterations parallel complex biphasic changes in glutamate-mediated excitatory, γ‎-aminobutyric acid (GABA)-mediated inhibitory synaptic transmission and dopamine modulation in medium spiny neurons of the striatum as well as in cortical pyramidal neurons. The progressive electrophysiologic changes in synaptic communication that occur with disease stage in the cortical and basal ganglia circuits of HD mouse models strongly indicate that therapeutic interventions and strategies in human HD must be targeted to different mechanisms in each stage and to specific subclasses of neurons.

scholarly journals Delayed Effects of Corticosterone on Slow After-Hyperpolarization Potentials in Mouse Hippocampal versus Prefrontal Cortical Pyramidal Neurons

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99208 ◽  
Author(s):  
Anup G. Pillai ◽  
Marloes J. A. G. Henckens ◽  
Guillén Fernández ◽  
Marian Joëls
Keyword(s):  
Pyramidal Neurons ◽  
Delayed Effects ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons

Postsynaptic excitation of prefrontal cortical pyramidal neurons by hypocretin-1/orexin a through the inhibition of potassium currents

2005 ◽  
Vol 82 (5) ◽  
pp. 729-736 ◽  
Author(s):  
Jianxia Xia ◽  
Xiaowei Chen ◽  
Chenghui Song ◽  
Jianning Ye ◽  
Zhengping Yu ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Potassium Currents ◽  
Orexin A ◽  
Prefrontal Cortical ◽  
Cortical Pyramidal Neurons ◽  
Hypocretin 1
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