scholarly journals Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells

2004 ◽  
Vol 11 (S1) ◽  
pp. S97-S107 ◽  
Author(s):  
C R Yang ◽  
J H Wang ◽  
S L Hsieh ◽  
S M Wang ◽  
T L Hsu ◽  
...  
Keyword(s):  
Osteoclast Formation ◽  
Precursor Cells ◽  
Decoy Receptor ◽  
Decoy Receptor 3 ◽  
Macrophage Lineage

scholarly journals Attenuation of Bone Mass and Increase of Osteoclast Formation in Decoy Receptor 3 Transgenic Mice

2006 ◽  
Vol 282 (4) ◽  
pp. 2346-2354 ◽  
Author(s):  
Chih-Hsin Tang ◽  
Tsui-Ling Hsu ◽  
Wan-Wan Lin ◽  
Ming-Zong Lai ◽  
Rong-Sen Yang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Bone Mass ◽  
Osteoclast Formation ◽  
Decoy Receptor ◽  
Decoy Receptor 3

scholarly journals Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Yi-Jen Peng ◽  
Ching-Tsung Peng ◽  
Yi-Hsuan Lin ◽  
Gu-Jiun Lin ◽  
Shing-Hwa Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bone Resorption ◽  
Fas Ligand ◽  
Interleukin 1 ◽  
Reactive Oxygen ◽  
Precursor Cells ◽  
Osteoclast Precursor ◽  
Oxygen Species ◽  
Decoy Receptor ◽  
Decoy Receptor 3

Purpose. Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator of monocytes and macrophages. The aim of this study was to investigate the mechanism of DCR3 in IL-1α-induced osteoclastogenesis. Methods. We treated murine macrophages with DCR3 during receptor activator of nuclear factor kappa Β ligand- (RANKL-) plus IL-1α-induced osteoclastogenesis to monitor osteoclast formation by tartrate-resistant acid phosphatase (TRAP) staining. Osteoclast activity was assessed using a pit formation assay. The mechanisms of inhibition were studied by biochemical analyses, including RT-PCR, immunofluorescent staining, flow cytometry, an apoptosis assay, immunoblotting, and ELISA. Results. DCR3 suppresses IL-1α-induced osteoclastogenesis in both primary murine bone marrow-derived macrophages (BMM) and RAW264.7 cells as it inhibits bone resorption. DCR3 induces RANKL-treated osteoclast precursor cells to express IL-1α, secretory IL-1ra (sIL-1ra), intracellular IL-1ra (icIL-1ra), reactive oxygen species (ROS), and Fas ligand and to activate IL-1α-induced interleukin-1 receptor-associated kinase 4 (IRAK4). The suppression of DCR3 during RANKL- or IL-1α-induced osteoclastogenesis may be due to the abundant secretion of IL-1ra, accumulation of ROS, and expression of Fas ligand in apoptotic osteoclast precursor cells. Conclusions. We concluded that there is an inhibitory effect of DCR3 on osteoclastogenesis via ROS accumulation and ROS-induced Fas ligand, IL-1α, and IL-1ra expression. Our results suggested that the upregulation of DCR3 in preosteoclasts might be a therapeutic target in inflammatory IL-1α-induced bone resorption.

scholarly journals Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer

2012 ◽  
Vol 13 (1) ◽  
pp. 28 ◽  
Author(s):  
Donghai Yang ◽  
Xin Fan ◽  
Ping Yin ◽  
Qiang Wen ◽  
Feng Yan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
External Signal ◽  
Decoy Receptor ◽  
Decoy Receptor 3

scholarly journals Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation

Bone Research ◽  
2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Bing Shu ◽  
Yongjian Zhao ◽  
Shitian Zhao ◽  
Haobo Pan ◽  
Rong Xie ◽  
...  
Keyword(s):  
Bone Growth ◽  
Osteoclast Formation ◽  
Precursor Cells

The formation of osteoclasts in multiple myeloma bone disease patients involves the secretion of soluble decoy receptor 3

2010 ◽  
Vol 1192 (1) ◽  
pp. 298-302 ◽  
Author(s):  
Giacomina Brunetti ◽  
Angela Oranger ◽  
Giorgio Mori ◽  
Matteo Centonze ◽  
Graziana Colaianni ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Disease ◽  
Decoy Receptor ◽  
Myeloma Bone Disease ◽  
Decoy Receptor 3

scholarly journals Sensitization of Cells to TRAIL-induced Apoptosis by Decoy Receptor 3

2004 ◽  
Vol 279 (42) ◽  
pp. 44211-44218 ◽  
Author(s):  
Y.-Y. Wu ◽  
Y.-C. Chang ◽  
T.-L. Hsu ◽  
S.-L. Hsieh ◽  
M.-Z. Lai
Keyword(s):  
Decoy Receptor ◽  
Decoy Receptor 3 ◽  
Induced Apoptosis
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