scholarly journals Sensitization of Cells to TRAIL-induced Apoptosis by Decoy Receptor 3

2004 ◽  
Vol 279 (42) ◽  
pp. 44211-44218 ◽  
Author(s):  
Y.-Y. Wu ◽  
Y.-C. Chang ◽  
T.-L. Hsu ◽  
S.-L. Hsieh ◽  
M.-Z. Lai
Keyword(s):  
Decoy Receptor ◽  
Decoy Receptor 3 ◽  
Induced Apoptosis

Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3)

Blood ◽  
2008 ◽  
Vol 111 (3) ◽  
pp. 1480-1488 ◽  
Author(s):  
Ren-In You ◽  
Yung-Chi Chang ◽  
Po-Min Chen ◽  
Wei-Shu Wang ◽  
Tsui-Ling Hsu ◽  
...  
Keyword(s):  
Immune Cell ◽  
Tumor Necrosis Factor Receptor ◽  
Cross Linking ◽  
Death Domain ◽  
Heparin Binding ◽  
Decoy Receptor ◽  
Signaling Complex ◽  
Heparin Binding Domain ◽  
Decoy Receptor 3 ◽  
Induced Apoptosis

Abstract Decoy receptor 3 (DcR3) is a soluble decoy receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily, and its expression is not only up-regulated in cancer cells derived from various cell lineages, but also correlates with overall survival of patients with cancer. It has been shown that DcR3 sensitize cells of hematopoietic origin to TNF-related apoptosis-inducing ligand (TRAIL)–induced apoptosis; therefore, we asked whether DcR3 down-regulated host immunity by inducing immune cell apoptosis. We demonstrate that DcR3 induces dendritic cell (DC) apoptosis by activating PKC-δ and JNK subsequently to up-regulate DR5 to recruit Fas-associated death domain (FADD) to propagate the apoptotic signals. The association of FADD with DR5 results in the formation of death-inducing signaling complex (DISC) to trigger the downstream apoptotic signaling cascade. PKC-δ is activated via cross-linking of heparan sulfate proteoglycan (HSPG) on DCs, because recombinant protein containing the heparin-binding domain (HBD) of DcR3 and the Fc portion of IgG1, the HBD.Fc fusion protein, is also able to trigger DC apoptosis. This provides the first evidence that cross-linking of HSPG on DCs can activate PKC-δ to induce DC apoptosis via the formation of DR5 DISC, and elucidates a novel mechanism of DcR3-mediated immunosuppression.

Decoy receptor 3 suppresses FasL-induced apoptosis via ERK1/2 activation in pancreatic cancer cells

2015 ◽  
Vol 463 (4) ◽  
pp. 1144-1151 ◽  
Author(s):  
Yi Zhang ◽  
Dechun Li ◽  
Xin Zhao ◽  
Shiduo Song ◽  
Lifeng Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Decoy Receptor ◽  
Pancreatic Cancer Cells ◽  
Decoy Receptor 3 ◽  
Induced Apoptosis

scholarly journals Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against fas-induced apoptosis

2007 ◽  
Vol 56 (4) ◽  
pp. 1067-1075 ◽  
Author(s):  
Shinya Hayashi ◽  
Yasushi Miura ◽  
Takayuki Nishiyama ◽  
Makoto Mitani ◽  
Koji Tateishi ◽  
...  
Keyword(s):  
Synovial Fibroblasts ◽  
Decoy Receptor ◽  
Decoy Receptor 3 ◽  
Induced Apoptosis

scholarly journals Sensitization of Cells to TRAIL-induced Apoptosis by Decoy Receptor 3

2004 ◽  
Vol 279 (42) ◽  
pp. 44211-44218 ◽  
Author(s):  
Ying-Yu Wu ◽  
Yung-Chi Chang ◽  
Tsui-Ling Hsu ◽  
Shie-Liang Hsieh ◽  
Ming-Zong Lai
Keyword(s):  
Decoy Receptor ◽  
Decoy Receptor 3 ◽  
Induced Apoptosis

scholarly journals Attenuation of Bone Mass and Increase of Osteoclast Formation in Decoy Receptor 3 Transgenic Mice

2006 ◽  
Vol 282 (4) ◽  
pp. 2346-2354 ◽  
Author(s):  
Chih-Hsin Tang ◽  
Tsui-Ling Hsu ◽  
Wan-Wan Lin ◽  
Ming-Zong Lai ◽  
Rong-Sen Yang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Bone Mass ◽  
Osteoclast Formation ◽  
Decoy Receptor ◽  
Decoy Receptor 3

scholarly journals Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer

2012 ◽  
Vol 13 (1) ◽  
pp. 28 ◽  
Author(s):  
Donghai Yang ◽  
Xin Fan ◽  
Ping Yin ◽  
Qiang Wen ◽  
Feng Yan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
External Signal ◽  
Decoy Receptor ◽  
Decoy Receptor 3
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