scholarly journals Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat

Spinal Cord ◽  
2015 ◽  
Vol 54 (5) ◽  
pp. 347-359 ◽  
Author(s):  
Y O Mukhamedshina ◽  
G F Shaymardanova ◽  
Е Е Garanina ◽  
I I Salafutdinov ◽  
А А Rizvanov ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Spinal Cord Injury ◽  
Blood Cell ◽  
Adenoviral Vector ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cell ◽  
Cord Injury ◽  
Direct Gene

scholarly journals Intraspinal Injection of Platelet-Rich Plasma Promotes Regeneration of the Spinal Cord and Improves Locomotor Function by Modulating the Apoptosis and the Wnt Signaling Pathways

2021 ◽  
Author(s):  
Zahra Behroozi ◽  
Fatemeh Ramezani ◽  
farinaz Nasirinezhad
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Wnt Signaling ◽  
Motor Function ◽  
Platelet Rich Plasma ◽  
Wnt Signaling Pathway ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Locomotor Function ◽  
Cord Injury

Abstract Background: There are complex mechanisms for reducing intrinsic repair ability and neuronal regeneration following spinal cord injury (SCI). Platelet-rich plasma (PRP) is a rich source of growth factors and has been used to stimulate regeneration of peripheral nerves in degenerationtive diseases. However, only a few studies have investigated the effects of PRP on the SCI models. We examined whether PRP derived from human umbilical cord blood (HUCB-PRP) could recover motor function in animals with spinal cord injury. We also investigate the role of Wnt signaling pathway.Methods: Ault male Wistar rats were randomly divided into 6 groups (n=60) as control, sham, SCI, vehicle (SCI+platelet-poor plasma), PRP2day (SCI+injection 2 days after SCI) and PRP14day (SCI+injection 14 days after SCI). SCI was performed at the T12-T13 level. BBB tests were done weekly after injury for six weeks. caspase3 expression was determined using the Immunohistochemistry technique. The expression of GSK3β, Tau and MAG were determined using the Western blot technique. Data were analyzed by PRISM & SPSS software. Results: PRP injected animals showed a higher locomotor function recovery than those in the SCI group (p<0.0001). The level of caspase3, GSK3β and CSF- Tau reduced and MAG level in the spinal cord increased by injection of HUCB-PRP in animals with spinal cord injury. Conclusions: Injection of HUCB-PRP enhanced hind limb locomotor performance by modulation of caspase3, GSK3β, tau and MAG expression. Using HUCB-PRP could be a new therapeutic option for recovering the motor function and axonal regeneration after spinal cord injury.

scholarly journals Assessment of Neuroprotective Properties ofMelissa officinalisin Combination With Human Umbilical Cord Blood Stem Cells After Spinal Cord Injury

ASN NEURO ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 175909141667483 ◽  
Author(s):  
Seyed Ruhollah Hosseini ◽  
Gholamreza Kaka ◽  
Mohammad Taghi Joghataei ◽  
Mehdi Hooshmandi ◽  
Seyed Homayoon Sadraie ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cord Blood ◽  
Umbilical Cord Blood ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Injury ◽  
Blood Stem Cells ◽  
Cord Blood Stem Cells

Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury

2009 ◽  
Vol 36 (1) ◽  
pp. 200-212 ◽  
Author(s):  
Krishna Kumar Veeravalli ◽  
Venkata Ramesh Dasari ◽  
Andrew J. Tsung ◽  
Dzung H. Dinh ◽  
Meena Gujrati ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Injury ◽  
Blood Stem Cells ◽  
Cord Blood Stem Cells
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