scholarly journals Differential expression of glycine receptor subunit messenger RNA in the rat following spinal cord injury

Spinal Cord ◽  
2010 ◽  
Vol 49 (2) ◽  
pp. 280-284 ◽  
Author(s):  
A Esmaeili ◽  
S R Zaker
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Differential Expression ◽  
Messenger Rna ◽  
Glycine Receptor ◽  
Receptor Subunit ◽  
Cord Injury

Differential expression of ryanodine receptor isoforms after spinal cord injury

2017 ◽  
Vol 660 ◽  
pp. 51-56 ◽  
Author(s):  
Nicolas Pelisch ◽  
Cynthia Gomes ◽  
Jacqueline M. Nally ◽  
Jeffrey C. Petruska ◽  
David P. Stirling
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Differential Expression ◽  
Ryanodine Receptor ◽  
Receptor Isoforms ◽  
Cord Injury

Glutamate receptor subunit expression after spinal cord injury in young rats

2004 ◽  
Vol 152 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Kwame M Brown ◽  
Jean R Wrathall ◽  
Robert P Yasuda ◽  
Barry B Wolfe
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glutamate Receptor ◽  
Receptor Subunit ◽  
Young Rats ◽  
Glutamate Receptor Subunit ◽  
Cord Injury ◽  
Subunit Expression

scholarly journals Differential expression of sPLA2following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death

Glia ◽  
2009 ◽  
Vol 57 (14) ◽  
pp. 1521-1537 ◽  
Author(s):  
W. Lee Titsworth ◽  
Xiaoxin Cheng ◽  
Yan Ke ◽  
Lingxiao Deng ◽  
Kenneth A. Burckardt ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Differential Expression ◽  
Functional Role ◽  
Cord Injury

scholarly journals Differential expression of synaptophysin and its functional implication under conditions of both contused and transected spinal cord injury

Ibrain ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 1-8
Author(s):  
Hao Yuan ◽  
Zhi‐Wei Chen ◽  
Xiu‐Juan Dong ◽  
Long‐Hui Zhou ◽  
Zhen‐Wu Sun ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Differential Expression ◽  
Functional Implication ◽  
Cord Injury

scholarly journals Loss of Central Inhibition: Implications for Behavioral Hypersensitivity after Contusive Spinal Cord Injury in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Yerko A. Berrocal ◽  
Vania W. Almeida ◽  
Rocio Puentes ◽  
Eric P. Knott ◽  
Jaclyn F. Hechtman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glycine Receptor ◽  
Thermal Hyperalgesia ◽  
Pain Syndromes ◽  
Model Following ◽  
Cutaneous Allodynia ◽  
Cord Injury ◽  
Central Inhibition ◽  
Biochemical Analyses

Behavioral hypersensitivity is common following spinal cord injury (SCI), producing significant discomfort and often developing into chronic pain syndromes. While the mechanisms underlying the development of behavioral hypersensitivity after SCI are poorly understood, previous studies of SCI contusion have shown an increase in amino acids, namely, aspartate and glutamate, along with a decrease in GABA and glycine, particularly below the injury. The current study sought to identify alterations in key enzymes and receptors involved in mediating central inhibition via GABA and glycine after a clinically-relevant contusion SCI model. Following thoracic (T8) 25.0 mm NYU contusion SCI in rodents, significant and persistent behavioral hypersensitivity developed as evidenced by cutaneous allodynia and thermal hyperalgesia. Biochemical analyses confirmed upregulation of glutamate receptor GluR3 with downregulation of the GABA synthesizing enzyme (GAD65/67) and the glycine receptor α3 (GLRA3), notably below the injury. Combined, these changes result in the disinhibition of excitatory impulses and contribute to behavioral hyperexcitability. This study demonstrates a loss of central inhibition and the development of behavioral hypersensitivity in a contusive SCI paradigm. Future use of this model will permit the evaluation of different antinociceptive strategies and help in the elucidation of new targets for the treatment of neuropathic pain.

Spinal cord injury induces differential expression of the profibrotic semaphorin 7A in the developing and mature glial scar

Glia ◽  
2010 ◽  
Vol 58 (14) ◽  
pp. 1748-1756 ◽  
Author(s):  
Marcel A. Kopp ◽  
Benedikt Brommer ◽  
Nicole Gatzemeier ◽  
Jan M. Schwab ◽  
Harald Prüss
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Differential Expression ◽  
Glial Scar ◽  
Cord Injury
Sign in / Sign up

Export Citation Format

Share Document