Spinal cord injury induces differential expression of the profibrotic semaphorin 7A in the developing and mature glial scar

Glia ◽  
2010 ◽  
Vol 58 (14) ◽  
pp. 1748-1756 ◽  
Author(s):  
Marcel A. Kopp ◽  
Benedikt Brommer ◽  
Nicole Gatzemeier ◽  
Jan M. Schwab ◽  
Harald Prüss
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Differential Expression ◽  
Glial Scar ◽  
Cord Injury

scholarly journals A Collagen-Based Scaffold for Promoting Neural Plasticity in a Rat Model of Spinal Cord Injury

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2245
Author(s):  
Jue-Zong Yeh ◽  
Ding-Han Wang ◽  
Juin-Hong Cherng ◽  
Yi-Wen Wang ◽  
Gang-Yi Fan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Neural Plasticity ◽  
Collagen Scaffold ◽  
Glial Scar ◽  
Beneficial Effects ◽  
Cord Injury

In spinal cord injury (SCI) therapy, glial scarring formed by activated astrocytes is a primary problem that needs to be solved to enhance axonal regeneration. In this study, we developed and used a collagen scaffold for glial scar replacement to create an appropriate environment in an SCI rat model and determined whether neural plasticity can be manipulated using this approach. We used four experimental groups, as follows: SCI-collagen scaffold, SCI control, normal spinal cord-collagen scaffold, and normal control. The collagen scaffold showed excellent in vitro and in vivo biocompatibility. Immunofluorescence staining revealed increased expression of neurofilament and fibronectin and reduced expression of glial fibrillary acidic protein and anti-chondroitin sulfate in the collagen scaffold-treated SCI rats at 1 and 4 weeks post-implantation compared with that in untreated SCI control. This indicates that the collagen scaffold implantation promoted neuronal survival and axonal growth within the injured site and prevented glial scar formation by controlling astrocyte production for their normal functioning. Our study highlights the feasibility of using the collagen scaffold in SCI repair. The collagen scaffold was found to exert beneficial effects on neuronal activity and may help in manipulating synaptic plasticity, implying its great potential for clinical application in SCI.

scholarly journals Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury

2018 ◽  
Vol 35 (15) ◽  
pp. 1745-1754 ◽  
Author(s):  
Nandadevi Patil ◽  
Vincent Truong ◽  
Mackenzie H. Holmberg ◽  
Nicolas S. Lavoie ◽  
Mark R. McCoy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rose Bengal ◽  
Glial Scar ◽  
Chronic Spinal Cord Injury ◽  
Safety And Efficacy ◽  
Cord Injury

Implantation Of Engineered Axon Tracts To Bridge Spinal Cord Injury Beyond The Glial Scar In Rats

2021 ◽  
Author(s):  
Patricia Zadnik Sullivan ◽  
Ahmed Albayar ◽  
Justin C. Burrell ◽  
Kevin Browne ◽  
John Arena ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Scar ◽  
Cord Injury
Sign in / Sign up

Export Citation Format

Share Document