scholarly journals Maternal thyroid function in pregnancy may program offspring blood pressure, but not adiposity at 20 y of age

2016 ◽  
Vol 80 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Dorte Rytter ◽  
Stine L. Andersen ◽  
Bodil H. Bech ◽  
Thorhallur I. Halldorsson ◽  
Tine B. Henriksen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Thyroid Function ◽  
Maternal Thyroid ◽  
In Pregnancy

Maternal thyroid function in pregnancy and risk of breech presentation

2015 ◽  
Author(s):  
Bridget Knight ◽  
Beverly Shields ◽  
Rachel Sturley ◽  
Bijay Vaidya
Keyword(s):  
Thyroid Function ◽  
Breech Presentation ◽  
Maternal Thyroid ◽  
In Pregnancy

Maternal hypothyroidism may be associated with CHD in offspring

2014 ◽  
Vol 25 (7) ◽  
pp. 1247-1253 ◽  
Author(s):  
Michael J Grattan ◽  
Daina S Thomas ◽  
Lisa K. Hornberger ◽  
Robert M Hamilton ◽  
William K Midodzi ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Negative Impact ◽  
Nausea And Vomiting ◽  
Thyroid Status ◽  
Cross Sectional ◽  
History Of ◽  
Maternal Thyroid ◽  
The Relationship ◽  
Control Study ◽  
In Pregnancy

AbstractObjectives:This study tested whether mothers with maternal hypothyroidism have increased odds of CHD in their offspring, and examined the relationship between CHD, maternal thyroid function, and nausea and vomiting in pregnancy.Background:Maternal hypothyroidism increases the risk for foetal demise and prematurity and can have a negative impact on neurodevelopment. Prior studies have postulated a relationship between maternal thyroid function, CHD, and maternal nausea and vomiting in pregnancy.Methods:A cross-sectional case–control study was conducted over a 17-month period to obtain a history of maternal thyroid status and nausea and vomiting in pregnancy. Paediatric echocardiograms were evaluated for CHD by a blinded paediatric cardiologist. Logistic regression analysis was performed to examine the association between CHD and maternal hypothyroidism.Results:Of the 998 maternal–child pairs, 10% (98/998) of the mothers reported a history of prenatal hypothyroidism. The overall prevalence of CHD in the study sample was 63% (630/998). Mothers with a history of hypothyroidism were significantly more likely to have offspring with CHD compared with mothers without a history of hypothyroidism (72 versus 62%; p=0.04). The adjusted odds ratio (95% confidence interval) of CHD in offspring associated with reported maternal hypothyroidism was 1.68 (1.02–2.78).Conclusion:This study suggests that maternal hypothyroidism is a risk factor for the development of CHD. Further prospective investigations are necessary to confirm this association and delineate pathogenic mechanisms.

Maternal thyroid function in pregnancy — a tale of two tails

2015 ◽  
Vol 12 (1) ◽  
pp. 10-11 ◽  
Author(s):  
Alex Stagnaro-Green ◽  
Joanne Rovet
Keyword(s):  
Thyroid Function ◽  
Maternal Thyroid ◽  
In Pregnancy

Associations Between Maternal Thyroid Function in Pregnancy and Obstetric and Perinatal Outcomes

2020 ◽  
Vol 75 (9) ◽  
pp. 553-554
Author(s):  
Sun Y. Lee ◽  
Howard J. Cabral ◽  
Ann Aschengrau ◽  
Elizabeth N. Pearce
Keyword(s):  
Thyroid Function ◽  
Perinatal Outcomes ◽  
Maternal Thyroid ◽  
In Pregnancy

scholarly journals Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women

2009 ◽  
Vol 161 (6) ◽  
pp. 903-910 ◽  
Author(s):  
Malene Boas ◽  
Julie Lyng Forman ◽  
Anders Juul ◽  
Ulla Feldt-Rasmussen ◽  
Niels Erik Skakkebæk ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Individual Variation ◽  
Reference Intervals ◽  
Specific Reference ◽  
Longitudinal Course ◽  
Individual Variations ◽  
Maternal Thyroid ◽  
In Pregnancy

BackgroundAdaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation.ObjectiveThe aim of the study was the assessment of the intra-individual variation as well as the longitudinal course of thyroid hormones during normal pregnancy and factors that influence the normal reference range for thyroid function. For this purpose, a longitudinal statistical model was applied.DesignIn a cohort of 132 pregnant women, serial blood samples were obtained and ultrasound scans were performed throughout pregnancy.MethodsSerum levels of TSH, free and total thyroxine (T4), free and total triiodothyronine (T3) as well as autoantibodies against thyroid peroxidase and thyroglobulin were measured in 979 serum samples.ResultsIntra-individual variations of thyroid hormone concentrations were smaller than inter-individual variations (individuality index range: 0.38–0.71). Maternal height was positively associated with free T4 (FT4) (b=0.003; P=0.031) and pre-pregnancy body mass index with T3 and free T3 (b=0.017; <0.001 and b=0.007; P<0.001). Smoking was positively associated with T4 and FT4, but it was modulated by gestational age. Gestation-specific reference intervals for thyroid function variables from autoantibody-negative participants are presented.ConclusionsIn accordance with the data from nonpregnant adults, intra-individual variations of thyroid hormones were smaller than inter-individual variations also during pregnancy. In the evaluation of thyroid function in pregnancy, the individual longitudinal course of thyroid hormones rather than absolute values should be considered. We present a longitudinal model for the prediction of maternal thyroid function tests in pregnant women.

scholarly journals Erratum: Maternal thyroid function in pregnancy — a tale of two tails

2015 ◽  
Vol 12 (2) ◽  
pp. 110-110 ◽  
Author(s):  
Alex Stagnaro-Green ◽  
Joanne Rovet
Keyword(s):  
Thyroid Function ◽  
Maternal Thyroid ◽  
In Pregnancy
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