scholarly journals Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy

2014 ◽  
Vol 77 (2) ◽  
pp. 363-369 ◽  
Author(s):  
Sushma Reddy ◽  
Alan Fung ◽  
Cedric Manlhiot ◽  
Elif Seda Selamet Tierney ◽  
Wendy K. Chung ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Adrenergic Receptor ◽  
Failure Severity ◽  
Β Blocker ◽  
Heart Failure Severity

scholarly journals Inflammation-Related Biomarkers Are Associated with Heart Failure Severity and Poor Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1006
Author(s):  
Ieva Kažukauskienė ◽  
Vaida Baltrūnienė ◽  
Ieva Rinkūnaitė ◽  
Edvardas Žurauskas ◽  
Dalius Vitkus ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Clinical Outcomes ◽  
Interleukin 6 ◽  
Cardiac Event ◽  
Tnf Α ◽  
Failure Severity ◽  
Non Ischemic Dilated Cardiomyopathy ◽  
Hs Crp ◽  
Heart Failure Severity

Inflammation-related biomarkers are associated with clinical outcomes in mixed-etiology chronic heart failure populations. Inflammation-related markers tend to be higher in ischemic than in non-ischemic dilated cardiomyopathy (NI-DCM) patients, which might impact their prognostic performance in NI-DCM patients. Therefore, we aimed to assess the association of inflammation-related biomarkers with heart failure severity parameters and adverse cardiac events in a pure NI-DCM patient cohort. Fifty-seven patients with NI-DCM underwent endomyocardial biopsy. Biopsies were evaluated by immunohistochemistry for CD3+, CD45ro+, CD68+, CD4+, CD54+, and HLA-DR+ cells. Blood samples were tested for high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-α (TNF-α), soluble urokinase-type plasminogen activator receptor and adiponectin. During a five-year follow-up, twenty-seven patients experienced at least one composite adverse cardiac event: left ventricle assist device implantation, heart transplantation or death. Interleukin-6, TNF-α and adiponectin correlated with heart failure severity parameters. Patients with higher levels of interleukin-6, TNF-α, adiponectin or hs-CRP, or a higher number of CD3+ or CD45ro+ cells, had lower survival rates. Interleukin-6, adiponectin, and CD45ro+ cells were independently associated with poor clinical outcomes. All patients who had interleukin-6, TNF-α and adiponectin concentrations above the threshold experienced an adverse cardiac event. Therefore, a combination of these cytokines can identify high-risk NI-DCM patients.

Plasma osteopontin levels, but not its myocardial expression, reflect heart failure severity in recently diagnosed dilated cardiomyopathy

Herz ◽  
2019 ◽  
Vol 45 (S1) ◽  
pp. 105-110
Author(s):  
J. Podzimkova ◽  
T. Palecek ◽  
P. Kuchynka ◽  
J. Marek ◽  
B. A. Danek ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Failure Severity ◽  
Heart Failure Severity

scholarly journals Raised Sympathetic Nerve Activity in Heart Failure and Central Sleep Apnea Is Due to Heart Failure Severity

Circulation ◽  
2003 ◽  
Vol 107 (10) ◽  
pp. 1396-1400 ◽  
Author(s):  
Darren Mansfield ◽  
David M. Kaye ◽  
Hanspeter Brunner La Rocca ◽  
Peter Solin ◽  
Murray D. Esler ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Central Sleep Apnea ◽  
Nerve Activity ◽  
Failure Severity ◽  
Heart Failure Severity

In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humans

2018 ◽  
Vol 11 (9) ◽  
pp. e201800066 ◽  
Author(s):  
Evgeny A. Shirshin ◽  
Yury I. Gurfinkel ◽  
Simon T. Matskeplishvili ◽  
Maria L. Sasonko ◽  
Nikolai P. Omelyanenko ◽  
...  
Keyword(s):  
Heart Failure ◽  
Optical Imaging ◽  
Viable Epidermis ◽  
Failure Severity ◽  
In Vivo Optical Imaging ◽  
Heart Failure Severity ◽  
Nailfold Capillaries

Heart Failure Severity Stratification Beyond INTERMACS Profiles

ASAIO Journal ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Rebecca Cogswell ◽  
Jerry D. Estep ◽  
Raquel Araujo-Gutierrez ◽  
Maria Masotti ◽  
Valmiki Majaraj ◽  
...  
Keyword(s):  
Heart Failure ◽  
Failure Severity ◽  
Heart Failure Severity

scholarly journals An α 2C -Adrenergic Receptor Polymorphism Alters the Norepinephrine-Lowering Effects and Therapeutic Response of the β-Blocker Bucindolol in Chronic Heart Failure

2010 ◽  
Vol 3 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Michael R. Bristow ◽  
Guinevere A. Murphy ◽  
Heidi Krause-Steinrauf ◽  
Jeffrey L. Anderson ◽  
John F. Carlquist ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Adrenergic Receptor ◽  
Therapeutic Response ◽  
Β Blocker ◽  
Receptor Polymorphism
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