In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humans

2018 ◽  
Vol 11 (9) ◽  
pp. e201800066 ◽  
Author(s):  
Evgeny A. Shirshin ◽  
Yury I. Gurfinkel ◽  
Simon T. Matskeplishvili ◽  
Maria L. Sasonko ◽  
Nikolai P. Omelyanenko ◽  
...  
Keyword(s):  
Heart Failure ◽  
Optical Imaging ◽  
Viable Epidermis ◽  
Failure Severity ◽  
In Vivo Optical Imaging ◽  
Heart Failure Severity ◽  
Nailfold Capillaries

scholarly journals In vivo optical imaging of cancer cell function and tumor microenvironment

2018 ◽  
Vol 109 (4) ◽  
pp. 912-918 ◽  
Author(s):  
Takeshi Imamura ◽  
Takashi Saitou ◽  
Ryosuke Kawakami
Keyword(s):  
Tumor Microenvironment ◽  
Optical Imaging ◽  
Cancer Cell ◽  
Cell Function ◽  
In Vivo Optical Imaging

scholarly journals In vivo optical imaging of folate receptor-β in head and neck squamous cell carcinoma

2014 ◽  
Vol 124 (8) ◽  
pp. E312-E319 ◽  
Author(s):  
Joel Y. Sun ◽  
Jiayin Shen ◽  
Joel Thibodeaux ◽  
Gang Huang ◽  
Yiguang Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Optical Imaging ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Folate Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
In Vivo Optical Imaging

scholarly journals Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates

2015 ◽  
Vol 27 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Kazuhide Sato ◽  
Alexander P. Gorka ◽  
Tadanobu Nagaya ◽  
Megan S. Michie ◽  
Roger R. Nani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Optical Imaging ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Antibody Conjugates ◽  
Imaging Properties ◽  
In Vivo Optical Imaging

scholarly journals Raised Sympathetic Nerve Activity in Heart Failure and Central Sleep Apnea Is Due to Heart Failure Severity

Circulation ◽  
2003 ◽  
Vol 107 (10) ◽  
pp. 1396-1400 ◽  
Author(s):  
Darren Mansfield ◽  
David M. Kaye ◽  
Hanspeter Brunner La Rocca ◽  
Peter Solin ◽  
Murray D. Esler ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sleep Apnea ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Central Sleep Apnea ◽  
Nerve Activity ◽  
Failure Severity ◽  
Heart Failure Severity

scholarly journals Inflammation-Related Biomarkers Are Associated with Heart Failure Severity and Poor Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1006
Author(s):  
Ieva Kažukauskienė ◽  
Vaida Baltrūnienė ◽  
Ieva Rinkūnaitė ◽  
Edvardas Žurauskas ◽  
Dalius Vitkus ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Clinical Outcomes ◽  
Interleukin 6 ◽  
Cardiac Event ◽  
Tnf Α ◽  
Failure Severity ◽  
Non Ischemic Dilated Cardiomyopathy ◽  
Hs Crp ◽  
Heart Failure Severity

Inflammation-related biomarkers are associated with clinical outcomes in mixed-etiology chronic heart failure populations. Inflammation-related markers tend to be higher in ischemic than in non-ischemic dilated cardiomyopathy (NI-DCM) patients, which might impact their prognostic performance in NI-DCM patients. Therefore, we aimed to assess the association of inflammation-related biomarkers with heart failure severity parameters and adverse cardiac events in a pure NI-DCM patient cohort. Fifty-seven patients with NI-DCM underwent endomyocardial biopsy. Biopsies were evaluated by immunohistochemistry for CD3+, CD45ro+, CD68+, CD4+, CD54+, and HLA-DR+ cells. Blood samples were tested for high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-α (TNF-α), soluble urokinase-type plasminogen activator receptor and adiponectin. During a five-year follow-up, twenty-seven patients experienced at least one composite adverse cardiac event: left ventricle assist device implantation, heart transplantation or death. Interleukin-6, TNF-α and adiponectin correlated with heart failure severity parameters. Patients with higher levels of interleukin-6, TNF-α, adiponectin or hs-CRP, or a higher number of CD3+ or CD45ro+ cells, had lower survival rates. Interleukin-6, adiponectin, and CD45ro+ cells were independently associated with poor clinical outcomes. All patients who had interleukin-6, TNF-α and adiponectin concentrations above the threshold experienced an adverse cardiac event. Therefore, a combination of these cytokines can identify high-risk NI-DCM patients.

scholarly journals Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer

2009 ◽  
Vol 14 (1) ◽  
pp. 014023 ◽  
Author(s):  
Nobuyuki Kosaka ◽  
Mikako Ogawa ◽  
Michelle R. Longmire ◽  
Peter L. Choyke ◽  
Hisataka Kobayashi
Keyword(s):  
Ovarian Cancer ◽  
Optical Imaging ◽  
In Vivo Optical Imaging
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