Multivariate analysis of 13C NMR spectra of branched copolymers prepared by initiator-fragment incorporation radical copolymerization of ethylene glycol dimethacrylate and tert-butyl methacrylate

2016 ◽  
Vol 48 (7) ◽  
pp. 793-800 ◽  
Author(s):  
Tomohiro Hirano ◽  
Ryota Kamiike ◽  
Yuchin Hsu ◽  
Hikaru Momose ◽  
Koichi Ute
Keyword(s):  
Multivariate Analysis ◽  
Ethylene Glycol ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Radical Copolymerization ◽  
Ethylene Glycol Dimethacrylate ◽  
Butyl Methacrylate ◽  
13C Nmr Spectra ◽  
Glycol Dimethacrylate ◽  
Branched Copolymers

scholarly journals Butyl Methacrylate-Co-Ethylene Glycol Dimethacrylate Monolith for Online in-Tube SPME-UHPLC-MS/MS to Determine Chlopromazine, Clozapine, Quetiapine, Olanzapine, and Their Metabolites in Plasma Samples

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 310 ◽  
Author(s):  
Luiz Beloti ◽  
Luis Miranda ◽  
Maria Queiroz
Keyword(s):  
Ethylene Glycol ◽  
Ethylene Glycol Dimethacrylate ◽  
Butyl Methacrylate ◽  
Infrared Spectrometry ◽  
Relative Standard Error ◽  
Plasma Samples ◽  
Glycol Dimethacrylate ◽  
Covalent Bonds ◽  
Relative Standard ◽  
Schizophrenic Patients

This manuscript describes a sensitive, selective, and online in-tube solid-phase microextraction coupled with an ultrahigh performance liquid chromatography-tandem mass spectrometry (in-tube SPME-UHPLC-MS/MS) method to determine chlopromazine, clozapine, quetiapine, olanzapine, and their metabolites in plasma samples from schizophrenic patients. Organic poly(butyl methacrylate-co-ethylene glycol dimethacrylate) monolith was synthesized on the internal surface of a fused silica capillary (covalent bonds) for in-tube SPME. Analyte extraction and analysis was conducted by connecting the monolithic capillary to an UHPLC-MS/MS system. The monolith was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectrometry (FTIR). The developed method presented adequate linearity for all the target antipsychotics: R2 was higher than 0.9975, lack-of-fit ranged from 0.115 to 0.955, precision had variation coefficients lower than 14.2%, and accuracy had relative standard error values ranging from −13.5% to 14.6%, with the exception of the lower limit of quantification (LLOQ). The LLOQ values in plasma samples were 10 ng mL−1 for all analytes. The developed method was successfully applied to determine antipsychotics and their metabolites in plasma samples from schizophrenic patients.

Multivariate analysis of 13C NMR spectra of methacrylate copolymers and homopolymer blends

Polymer ◽  
2009 ◽  
Vol 50 (15) ◽  
pp. 3819-3821 ◽  
Author(s):  
Hikaru Momose ◽  
Kosuke Hattori ◽  
Tomohiro Hirano ◽  
Koichi Ute
Keyword(s):  
Multivariate Analysis ◽  
13C Nmr ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
Methacrylate Copolymers ◽  
Homopolymer Blends
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