scholarly journals Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma

Oncogene ◽  
2016 ◽  
Vol 36 (21) ◽  
pp. 3025-3036 ◽  
Author(s):  
H Gurler Main ◽  
J Xie ◽  
G G Muralidhar ◽  
O Elfituri ◽  
H Xu ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Peritoneal Metastasis ◽  
Epithelial Ovarian Carcinoma

scholarly journals Involvement of SDF-1α/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma

2007 ◽  
Vol 122 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Hiroaki Kajiyama ◽  
Kiyosumi Shibata ◽  
Mikio Terauchi ◽  
Kazuhiko Ino ◽  
Akihiro Nawa ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Peritoneal Metastasis ◽  
Epithelial Ovarian Carcinoma ◽  
Cxcr4 Axis

scholarly journals Role of Farletuzumab in Epithelial Ovarian Carcinoma

2012 ◽  
Vol 18 (25) ◽  
pp. 3812-3815 ◽  
Author(s):  
Danijela Jelovac ◽  
Deborah K. Armstrong
Keyword(s):  
Ovarian Carcinoma ◽  
Epithelial Ovarian Carcinoma

scholarly journals Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Marina Bagnoli ◽  
Giovanni L. Beretta ◽  
Laura Gatti ◽  
Silvana Pilotti ◽  
Paola Alberti ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
Tumor Grade ◽  
Tissue Microarrays ◽  
Epithelial Ovarian Carcinoma ◽  
Initial Surgery ◽  
Platinum Based Chemotherapy ◽  
Multiple Drugs ◽  
Paclitaxel Treatment

Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure. Although ABC transporters have been implicated in cellular resistance to multiple drugs, the clinical relevance of these efflux pumps is still poorly understood. Thus, we examined the prognostic role of transporters of the MRP family (i.e., ABCC1/MRP1, ABCC4/MRP4) to gain insights into their clinical impacts. A case material of 127 patients with ovarian carcinoma at different stages and histotypes was used. The expression of MRP1 and MRP4 was examined by immunohistochemistry using tissue microarrays in tumor specimens collected at the time of initial surgery expression. We found an association between MRP1 expression and grading, and we observed that MRP4 displayed an unfavourable impact on disease relapse in multivariate analysis (HR = 2.05, 95% CI: 1.01–4.11;P=0.045). These results suggest that in epithelial ovarian cancer, MRP1 may be a marker for aggressiveness because its expression was associated with tumor grade and support that MRP4 may play an unfavourable role in disease outcome.

Heterogeneous Role of Caspase-8 in Fenretinide-Induced Apoptosis in Epithelial Ovarian Carcinoma Cell Lines

2003 ◽  
Vol 64 (6) ◽  
pp. 1434-1443 ◽  
Author(s):  
Kimberly R. Kalli ◽  
Kathryn E. Devine ◽  
Myles C. Cabot ◽  
Christina R. Arnt ◽  
Michael P. Heldebrant ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Epithelial Ovarian Carcinoma ◽  
Caspase 8 ◽  
Carcinoma Cell Lines ◽  
Induced Apoptosis

The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway

2017 ◽  
Vol 57 (2) ◽  
pp. 225-234 ◽  
Author(s):  
Shuo Chen ◽  
Li-li Wang ◽  
Kai-Xuan Sun ◽  
Yin-ling Xiu ◽  
Zhi-Hong Zong ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Epithelial Ovarian Carcinoma ◽  
Non Coding Rna ◽  
Tumorigenesis And Progression ◽  
Long Non Coding Rna
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