Heterogeneous Role of Caspase-8 in Fenretinide-Induced Apoptosis in Epithelial Ovarian Carcinoma Cell Lines

2003 ◽  
Vol 64 (6) ◽  
pp. 1434-1443 ◽  
Author(s):  
Kimberly R. Kalli ◽  
Kathryn E. Devine ◽  
Myles C. Cabot ◽  
Christina R. Arnt ◽  
Michael P. Heldebrant ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Epithelial Ovarian Carcinoma ◽  
Caspase 8 ◽  
Carcinoma Cell Lines ◽  
Induced Apoptosis

Akt inhibitor enhances apoptotic effect of carboplatin on human epithelial ovarian carcinoma cell lines

2010 ◽  
Vol 632 (1-3) ◽  
pp. 7-13 ◽  
Author(s):  
Chung Soo Lee ◽  
Yun Jeong Kim ◽  
Eun-Ra Jang ◽  
Soon Chul Myung ◽  
Wonyong Kim
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Epithelial Ovarian Carcinoma ◽  
Akt Inhibitor ◽  
Carcinoma Cell Lines ◽  
Apoptotic Effect

scholarly journals Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling

Endocrinology ◽  
2002 ◽  
Vol 143 (9) ◽  
pp. 3259-3267 ◽  
Author(s):  
Kimberly R. Kalli ◽  
Oluwole I. Falowo ◽  
Laurie K. Bale ◽  
Michael A. Zschunke ◽  
Patrick C. Roche ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
Insulin Receptor ◽  
Cell Lines ◽  
Cancer Cell ◽  
Carcinoma Cell ◽  
Insulin Binding ◽  
Cell Number ◽  
Epithelial Ovarian Carcinoma ◽  
Carcinoma Cell Lines

Abstract The insulin receptor mediates a proliferative response in certain transformed cells, but little is known about its function in ovarian cancer. We used human epithelial ovarian carcinoma cell lines and lifespan-extended normal ovarian surface epithelial (OSE) cells to examine 125I-insulin binding and mitogenic responses to insulin. All cancer cell and OSE cultures specifically bound 125I-insulin. Except for OV202, the carcinoma lines had elevated insulin binding compared with OSE cells. All carcinoma lines except OV202 expressed insulin receptor as detected by flow cytometry and increased 3H-thymidine incorporation or cell number in response to 0.1–10 nm insulin. Interestingly, similar concentrations of IGF-II also induced proliferation of the insulin-responsive cancer cell lines and displaced 125I-insulin binding. Direct binding of 125I-IGF-II to the insulin receptor was visualized by cross-linking and immunoprecipitation. Binding of IGF-II to the insulin receptor and a proliferative effect of insulin suggest the presence of insulin receptor isoform A. Real-time PCR analyses confirm that insulin receptor isoform A expression predominates over isoform B expression in the ovarian carcinoma cell lines. This report suggests that the insulin receptor may play a role in the regulation of ovarian cancer cell growth.

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