Syndecan-1 increases B-lymphoid cell extravasation in response to HIV-1 Tat via αvβ3/pp60src/pp125FAK pathway

Oncogene ◽  
2016 ◽  
Vol 36 (18) ◽  
pp. 2609-2618 ◽  
Author(s):  
C Urbinati ◽  
E Grillo ◽  
P Chiodelli ◽  
C Tobia ◽  
F Caccuri ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
B Lymphoid ◽  
Hiv 1

Characterization of a New Hgprt(-) Human B Lymphoid Cell Line

1984 ◽  
pp. 873-876
Author(s):  
C. MILANESE ◽  
F. MALAVASI ◽  
F. CALIGARIS CAPPIO ◽  
B. ALHADEFF ◽  
G. PICCOLI ◽  
...  
Keyword(s):  
Cell Line ◽  
Lymphoid Cell ◽  
Lymphoid Cell Line ◽  
B Lymphoid

scholarly journals Heterogeneity of B cell involvement in acute nonlymphocytic leukemia

Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 342-344 ◽  
Author(s):  
AM Ferraris ◽  
WH Raskind ◽  
BH Bjornson ◽  
RJ Jacobson ◽  
JW Singer ◽  
...  
Keyword(s):  
Stem Cell ◽  
B Cell ◽  
Progenitor Cells ◽  
Cell Lines ◽  
Lymphoid Cell ◽  
Mononuclear Cells ◽  
Acute Nonlymphocytic Leukemia ◽  
Peripheral Blood Mononuclear ◽  
B Lymphoid ◽  
Lymphoid Cell Lines

Abstract In order to study the pattern of B cell involvement in acute nonlymphocytic leukemia (ANLL), multiple B lymphoid cell lines were established by Epstein-Barr virus transformation of peripheral blood mononuclear cells from two patients with the disease who were heterozygous for the X chromosome-linked glucose-6-phosphate dehydrogenase (G6PD). In one patient, the progenitor cells involved by the leukemia exhibited multipotent differentiative expression, whereas in the other patient the cells showed differentiative expression restricted to the granulocytic pathway. In the patient whose abnormal clone showed multipotent expression, the ratio of B-A G6PD in B lymphoid cell lines was skewed in the direction of type B (the enzyme characteristic of the leukemia clone) and significantly different from the 1:1 ratio expected. It is, therefore, likely that the neoplastic event occurred in a stem cell common to the lymphoid series as well as to the myeloid series. In contrast, evidence for B cell involvement was not detected in the patient whose ANLL progenitor cells exhibited restricted differentiative expression. These findings underscore the heterogeneity of ANLL. Clinically and morphologically similar malignancies in these two patients originated in progenitors with different patterns of stem cell differentiative expression. This difference may reflect differences in cause and pathogenesis.

scholarly journals UDP-GlcNAc:Gal 1->3GalNAc (GlcNAc to GalNAc)  1->6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines

Glycobiology ◽  
1999 ◽  
Vol 9 (1) ◽  
pp. 1-12 ◽  
Author(s):  
M. Nakamura ◽  
Y. Furukawa ◽  
R. Sasaki ◽  
J.-i. Masuyama ◽  
J. Kikuchi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Lymphoid Cell ◽  
B Lymphoid ◽  
Lymphoid Cell Lines

Sperm protein 17 is expressed on normal and malignant lymphocytes and promotes heparan sulfate–mediated cell-cell adhesion

Blood ◽  
2001 ◽  
Vol 98 (7) ◽  
pp. 2160-2165 ◽  
Author(s):  
H. Marie Lacy ◽  
Ralph D. Sanderson
Keyword(s):  
Cell Adhesion ◽  
Heparan Sulfate ◽  
Lymphoid Cell ◽  
Specific Antigen ◽  
Cell Aggregation ◽  
Lymphoid Cells ◽  
Sperm Protein ◽  
And Migration ◽  
B Lymphoid ◽  
Sperm Protein 17

Sperm protein 17 (Sp17) is a highly conserved mammalian protein present on acrosome-reacted sperm that is thought to promote fertilization by binding sulfated carbohydrates of the oocyte zona pellucida. Although Sp17 was originally described as a testis-specific antigen, emerging evidence indicates that it may be more ubiquitously expressed than was previously thought. With the use of a specific antiserum, Sp17 was found to be present on the surface of malignant lymphoid cells, including B- and T-lymphoid cell lines, and on the surface of primary cells isolated from 2 patients having B-lymphoid tumors. Surprisingly, circulating B lymphocytes isolated from healthy volunteers also expressed Sp17, while circulating T lymphocytes exhibited only very weak expression. The role of Sp17 in promoting lymphoid cell adhesion was addressed with the use of recombinant Sp17 (rSp17). The rSp17 binds to the surface of myeloma cells but not to cells pretreated with heparitinase, an enzyme that removes heparan sulfate from the cell surface. Moreover, rSp17 promotes extensive aggregation of cells that express the syndecan-1 heparan sulfate proteoglycan, but in contrast, cells lacking syndecan-1 expression fail to aggregate in the presence of rSp17. These findings suggest that Sp17 promotes heparan sulfate–mediated cell aggregation and thereby plays a role in regulating adhesion and migration of normal and malignant lymphocytes.

scholarly journals Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

2016 ◽  
Vol 7 (3) ◽  
pp. e2132-e2132 ◽  
Author(s):  
S Grabow ◽  
G L Kelly ◽  
A R D Delbridge ◽  
P N Kelly ◽  
P Bouillet ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
B Lymphoid

scholarly journals Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

1991 ◽  
Vol 11 (12) ◽  
pp. 6185-6191 ◽  
Author(s):  
R B Wilson ◽  
M Kiledjian ◽  
C P Shen ◽  
R Benezra ◽  
P Zwollo ◽  
...  
Keyword(s):  
Cell Lines ◽  
Lymphoid Cell ◽  
Ectopic Expression ◽  
Cell Development ◽  
Bhlh Protein ◽  
Chain Gene ◽  
Light Chain Gene ◽  
Helix Loop Helix ◽  
B Lymphoid

It has been proposed that the helix-loop-helix (HLH) protein Id serves as a general antagonist of cell differentiation by inhibiting bHLH (HLH with an adjacent stretch of basic amino acids) proteins specifically required for developmental programs (such as MyoD). We show here that ectopic expression of Id represses in vivo activity of the bHLH protein E2-5 (encoded by the E2A gene) and of both the immunoglobulin heavy-chain (IgH) and kappa-light-chain gene enhancers to which E2-5 binds. Id does not affect the activity of the bHLH-zip protein, TFE3, which also binds these enhancers. We examined a large panel of B-cell lines that represent different stages of lymphoid development and found only two that express Id mRNA. The cell lines Ba/F3 and LyD9 have been categorized previously as early B-lymphoid-cell progenitors. Unlike their more mature B-lymphoid-cell counterparts, Ba/F3 and LyD9 cells do not express I mu sterile transcripts, which are indicative of IgH enhancer activity. Moreover, Ba/F3-derived nuclear extracts lack E2-box-binding activity, indicating the absence of free bHLH proteins, and transfected Ba/F3 cells fail to support the activity of the IgH enhancer. Hence, expression of Id correlates inversely with bHLH protein activity and enhancer function in vivo. These results suggest that Id may play a role early in B-lymphoid-cell development to regulate transcription of the IgH locus.

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