scholarly journals Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

2016 ◽  
Vol 7 (3) ◽  
pp. e2132-e2132 ◽  
Author(s):  
S Grabow ◽  
G L Kelly ◽  
A R D Delbridge ◽  
P N Kelly ◽  
P Bouillet ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
B Lymphoid

Characterization of a New Hgprt(-) Human B Lymphoid Cell Line

1984 ◽  
pp. 873-876
Author(s):  
C. MILANESE ◽  
F. MALAVASI ◽  
F. CALIGARIS CAPPIO ◽  
B. ALHADEFF ◽  
G. PICCOLI ◽  
...  
Keyword(s):  
Cell Line ◽  
Lymphoid Cell ◽  
Lymphoid Cell Line ◽  
B Lymphoid

scholarly journals Heterogeneity of B cell involvement in acute nonlymphocytic leukemia

Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 342-344 ◽  
Author(s):  
AM Ferraris ◽  
WH Raskind ◽  
BH Bjornson ◽  
RJ Jacobson ◽  
JW Singer ◽  
...  
Keyword(s):  
Stem Cell ◽  
B Cell ◽  
Progenitor Cells ◽  
Cell Lines ◽  
Lymphoid Cell ◽  
Mononuclear Cells ◽  
Acute Nonlymphocytic Leukemia ◽  
Peripheral Blood Mononuclear ◽  
B Lymphoid ◽  
Lymphoid Cell Lines

Abstract In order to study the pattern of B cell involvement in acute nonlymphocytic leukemia (ANLL), multiple B lymphoid cell lines were established by Epstein-Barr virus transformation of peripheral blood mononuclear cells from two patients with the disease who were heterozygous for the X chromosome-linked glucose-6-phosphate dehydrogenase (G6PD). In one patient, the progenitor cells involved by the leukemia exhibited multipotent differentiative expression, whereas in the other patient the cells showed differentiative expression restricted to the granulocytic pathway. In the patient whose abnormal clone showed multipotent expression, the ratio of B-A G6PD in B lymphoid cell lines was skewed in the direction of type B (the enzyme characteristic of the leukemia clone) and significantly different from the 1:1 ratio expected. It is, therefore, likely that the neoplastic event occurred in a stem cell common to the lymphoid series as well as to the myeloid series. In contrast, evidence for B cell involvement was not detected in the patient whose ANLL progenitor cells exhibited restricted differentiative expression. These findings underscore the heterogeneity of ANLL. Clinically and morphologically similar malignancies in these two patients originated in progenitors with different patterns of stem cell differentiative expression. This difference may reflect differences in cause and pathogenesis.

scholarly journals Role of myeloid cells in the regulation of group 2 innate lymphoid cell‐mediated allergic inflammation

Immunology ◽  
2020 ◽  
Vol 161 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Aihua Lei ◽  
Yumei He ◽  
Qiong Yang ◽  
Xiaofang Li ◽  
Ranhui Li
Keyword(s):  
Lymphoid Cell ◽  
Myeloid Cells ◽  
Allergic Inflammation ◽  
Innate Lymphoid Cell ◽  
Group 2

scholarly journals UDP-GlcNAc:Gal 1->3GalNAc (GlcNAc to GalNAc)  1->6N-acetylglucosaminyltransferase holds a key role on the control of CD15s expression in human pre-B lymphoid cell lines

Glycobiology ◽  
1999 ◽  
Vol 9 (1) ◽  
pp. 1-12 ◽  
Author(s):  
M. Nakamura ◽  
Y. Furukawa ◽  
R. Sasaki ◽  
J.-i. Masuyama ◽  
J. Kikuchi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Lymphoid Cell ◽  
B Lymphoid ◽  
Lymphoid Cell Lines

scholarly journals Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers

Leukemia ◽  
2020 ◽  
Vol 34 (12) ◽  
pp. 3348-3358 ◽  
Author(s):  
Shenfei Sun ◽  
Ning Jiang ◽  
Yamei Jiang ◽  
Qiuping He ◽  
Hua He ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Dominant Role ◽  
Chromatin Accessibility ◽  
Chromatin Remodeler ◽  
Hematopoietic Stem ◽  
Stem Cell Quiescence ◽  
B Lymphoid ◽  
Stem Cell Pool

AbstractHematopoietic stem cell (HSC) utilizes its quiescence feature to combat exhaustion for lifetime blood cell supply. To date, how certain chromatin architecture and subsequent transcription profile permit HSC quiescence remains unclear. Here, we show an essential role of chromatin remodeler zinc finger HIT-type containing 1 (Znhit1) in maintaining HSC quiescence. We find that loss of Znhit1 leads to exhaustion of stem cell pool and impairment of hematopoietic function. Mechanically, Znhit1 determines the chromatin accessibility at distal enhancers of HSC quiescence genes, including Pten, Fstl1, and Klf4, for sustained transcription and consequent PI3K–Akt signaling inhibition. Moreover, Znhit1–Pten–PI3K–Akt axis also participates in controlling myeloid expansion and B-lymphoid specification. Our findings therefore identify a dominant role of Znhit1-mediated chromatin remodeling in preserving HSC function for hematopoietic homeostasis.

Syndecan-1 increases B-lymphoid cell extravasation in response to HIV-1 Tat via αvβ3/pp60src/pp125FAK pathway

Oncogene ◽  
2016 ◽  
Vol 36 (18) ◽  
pp. 2609-2618 ◽  
Author(s):  
C Urbinati ◽  
E Grillo ◽  
P Chiodelli ◽  
C Tobia ◽  
F Caccuri ◽  
...  
Keyword(s):  
Lymphoid Cell ◽  
B Lymphoid ◽  
Hiv 1

Sperm protein 17 is expressed on normal and malignant lymphocytes and promotes heparan sulfate–mediated cell-cell adhesion

Blood ◽  
2001 ◽  
Vol 98 (7) ◽  
pp. 2160-2165 ◽  
Author(s):  
H. Marie Lacy ◽  
Ralph D. Sanderson
Keyword(s):  
Cell Adhesion ◽  
Heparan Sulfate ◽  
Lymphoid Cell ◽  
Specific Antigen ◽  
Cell Aggregation ◽  
Lymphoid Cells ◽  
Sperm Protein ◽  
And Migration ◽  
B Lymphoid ◽  
Sperm Protein 17

Sperm protein 17 (Sp17) is a highly conserved mammalian protein present on acrosome-reacted sperm that is thought to promote fertilization by binding sulfated carbohydrates of the oocyte zona pellucida. Although Sp17 was originally described as a testis-specific antigen, emerging evidence indicates that it may be more ubiquitously expressed than was previously thought. With the use of a specific antiserum, Sp17 was found to be present on the surface of malignant lymphoid cells, including B- and T-lymphoid cell lines, and on the surface of primary cells isolated from 2 patients having B-lymphoid tumors. Surprisingly, circulating B lymphocytes isolated from healthy volunteers also expressed Sp17, while circulating T lymphocytes exhibited only very weak expression. The role of Sp17 in promoting lymphoid cell adhesion was addressed with the use of recombinant Sp17 (rSp17). The rSp17 binds to the surface of myeloma cells but not to cells pretreated with heparitinase, an enzyme that removes heparan sulfate from the cell surface. Moreover, rSp17 promotes extensive aggregation of cells that express the syndecan-1 heparan sulfate proteoglycan, but in contrast, cells lacking syndecan-1 expression fail to aggregate in the presence of rSp17. These findings suggest that Sp17 promotes heparan sulfate–mediated cell aggregation and thereby plays a role in regulating adhesion and migration of normal and malignant lymphocytes.

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