scholarly journals The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis

Oncogene ◽  
2015 ◽  
Vol 34 (50) ◽  
pp. 6105-6114 ◽  
Author(s):  
J M Park ◽  
T Wu ◽  
A R Cyr ◽  
G W Woodfield ◽  
J P De Andrade ◽  
...  
Keyword(s):  
Mammary Carcinogenesis ◽  
Cancer Growth

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Life Sciences ◽  
2021 ◽  
pp. 119005
Author(s):  
Sepideh Mirzaei ◽  
Ali Zarrabi ◽  
Sholeh Etehad Asnaf ◽  
Farid Hashemi ◽  
Amirhossein Zabolian ◽  
...  
Keyword(s):  
Cancer Growth
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