scholarly journals Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers

Oncogene ◽  
2012 ◽  
Vol 32 (12) ◽  
pp. 1560-1569 ◽  
Author(s):  
C G Lee ◽  
G-Y Park ◽  
Y K Han ◽  
J H Lee ◽  
S H Chun ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Mitotic Progression ◽  
Potential Use

Amphiregulin in cellular physiology, health, and disease: Potential use as a biomarker and therapeutic target

2021 ◽  
Author(s):  
Siddharth S. Singh ◽  
Shashi B. Chauhan ◽  
Awnish Kumar ◽  
Shashi Kumar ◽  
Christian R. Engwerda ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Cellular Physiology ◽  
Health And Disease ◽  
Potential Use

Stem cells and their potential relevance to paediatric cardiology

2006 ◽  
Vol 16 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Frank Pillekamp ◽  
Michael Reppel ◽  
Konrad Brockmeier ◽  
Jürgen Hescheler
Keyword(s):  
Stem Cells ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Cardiac Disease ◽  
Therapeutic Target ◽  
Current Knowledge ◽  
Young Patients ◽  
Short Review ◽  
Potential Use ◽  
In Infants And Children

Basic scientists, as well as cardiologists, are caught by the idea of curing ischaemic heart disease with cardiac progenitor or stem cells. This short review provides an overview of our current knowledge on the potential use of stem cells for cardiac disease. Since, in infants and children, aetiologies and pathomechanisms of critical cardiac disease are fundamentally different from those in adults, we will also address the question as to whether such young patients could be a therapeutic target at all, and in which respect it may be necessary to view treatment with stem cells from a different stance in the developing organism.

scholarly journals The cell cycle as a therapeutic target againstTrypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms

2009 ◽  
Vol 72 (2) ◽  
pp. 442-458 ◽  
Author(s):  
Neal Jetton ◽  
Karen G. Rothberg ◽  
James G. Hubbard ◽  
John Wise ◽  
Yan Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Therapeutic Target ◽  
Aurora Kinase ◽  
Mitotic Progression

scholarly journals PBK/TOPK: A Therapeutic Target Worthy of Attention

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 371
Author(s):  
Ziping Han ◽  
Lingzhi Li ◽  
Yuyou Huang ◽  
Haiping Zhao ◽  
Yumin Luo
Keyword(s):  
Cell Cycle ◽  
Therapeutic Target ◽  
Cell Cycle Progression ◽  
Killer Cell ◽  
Adult Brain ◽  
Clinical Settings ◽  
Cycle Progression ◽  
Pathological Conditions ◽  
Potential Use

Accumulating evidence supports the role of PDZ-binding kinase (PBK)/T-lymphokine-activated killer-cell-originated protein kinase (TOPK) in mitosis and cell-cycle progression of mitotically active cells, especially proliferative malignant cells. PBK/TOPK was confirmed to be associated with the development, progression, and metastasis of malignancies. Therefore, it is a potential therapeutic target in cancer therapy. Many studies have been conducted to explore the clinical applicability of potent PBK/TOPK inhibitors. However, PBK/TOPK has also been shown to be overexpressed in normal proliferative cells, including sperm and neural precursor cells in the subventricular zone of the adult brain, as well as under pathological conditions, such as ischemic tissues, including the heart, brain, and kidney, and plays important roles in their physiological functions, including proliferation and self-renewal. Thus, more research is warranted to further our understanding of PBK/TOPK inhibitors before we can consider their applicability in clinical practice. In this study, we first review the findings, general features, and signaling mechanisms involved in the regulation of mitosis and cell cycle. We then review the functions of PBK/TOPK in pathological conditions, including tumors and ischemic conditions in the heart, brain, and kidney. Finally, we summarize the advances in potent and selective inhibitors and describe the potential use of PBK/TOPK inhibitors in clinical settings.

scholarly journals Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

2010 ◽  
Vol 335 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Lauren M. Aleksunes ◽  
Michael J. Goedken ◽  
Cheryl E. Rockwell ◽  
Juergen Thomale ◽  
Jose E. Manautou ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Therapeutic Target ◽  
Potential Use

The growth of mica polytypes as studied by conventional and high-resolution TEM

1983 ◽  
Vol 41 ◽  
pp. 174-177
Author(s):  
A. Baronnet ◽  
M. Amouric
Keyword(s):  
Water Pressure ◽  
Point Of View ◽  
Temperature Fields ◽  
Natural Occurrence ◽  
Growth Mechanisms ◽  
Long Period ◽  
High Resolution Tem ◽  
Layer Stacking ◽  
Experimental Works ◽  
Potential Use

The origin of mica polytypes has long been a challenging problem for crystal- lographers, mineralogists and petrologists. From the petrological point of view, interest in this field arose from the potential use of layer stacking data to furnish further informations about equilibrium and/or kinetic conditions prevailing during the crystallization of the widespread mica-bearing rocks. From the compilation of previous experimental works dealing with the occurrence domains of the various mica "polymorphs" (1Mr, 1M, 2M1, 2M2 and 3T) within water-pressure vs temperature fields, it became clear that most of these modifications should be considered as metastable for a fixed mica species. Furthermore, the natural occurrence of long-period (or complex) polytypes could not be accounted for by phase considerations. This highlighted the need of a more detailed kinetic approach of the problem and, in particular, of the role growth mechanisms of basal faces could play in this crystallographic phenomenon.

An atomic-resolution microscope study of Al contracts on GaAs

1986 ◽  
Vol 44 ◽  
pp. 726-727
Author(s):  
Z. Liliental-Weber ◽  
C. Nelson ◽  
R. Ludeke ◽  
R. Gronsky ◽  
J. Washburn
Keyword(s):  
High Speed ◽  
Schottky Contacts ◽  
Detailed Knowledge ◽  
The Past ◽  
Semiconductor Interfaces ◽  
Deposited Metal ◽  
Microwave Applications ◽  
Free Interfaces ◽  
Potential Use

The properties of metal/semiconductor interfaces have received considerable attention over the past few years, and the Al/GaAs system is of special interest because of its potential use in high-speed logic integrated optics, and microwave applications. For such materials a detailed knowledge of the geometric and electronic structure of the interface is fundamental to an understanding of the electrical properties of the contact. It is well known that the properties of Schottky contacts are established within a few atomic layers of the deposited metal. Therefore surface contamination can play a significant role. A method for fabricating contamination-free interfaces is absolutely necessary for reproducible properties, and molecularbeam epitaxy (MBE) offers such advantages for in-situ metal deposition under UHV conditions

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

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