scholarly journals Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype

Oncogene ◽  
2011 ◽  
Vol 31 (6) ◽  
pp. 671-682 ◽  
Author(s):  
J Jiang ◽  
Y Zhang ◽  
S Chuai ◽  
Z Wang ◽  
D Zheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gastric Cancer Stem Cells

Increased Production of Matrix Metalloproteinases in Helicobacter pylori Infection that Stimulates Gastric Cancer Stem Cells

2020 ◽  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Helicobacter Pylori ◽  
Cancer Stem Cells ◽  
Histopathological Examination ◽  
Physiological Saline ◽  
Rrna Gene ◽  
Peptic Ulcers ◽  
Gastric Cancer Stem Cells ◽  
H Pylori

Background and aim: Helicobacter pylori (H. pylori) is an incriminated pathogen causing diseases in both animals and humans and considered a zoonotic pathogen. H. pylori infection is considered a cause of gastric cancer, which rests a significant health care challenge. This study analyzes the expression pattern of matrix metalloprotein 2 (MMP-2) in patients with Helicobacter pylori-associated gastritis and the effect of H. pylori on gastric cancer stem cells, as well as study the role of helicon bacteriosis in dog in transmission of H. pylori infection to human. Materials and methods: Fifty-five of each sample (gastric biopsy, blood and stool) were collected from patients suffering from dyspepsia, chronic vomiting and perforated peptic ulcers and also from apparent healthy dogs. The investigation detected H. pylori by serological and histopathological examination. Biopsies were stored in physiological saline for identification of H. pylori by conventional time PCR. MMP-2 and Gastric cancer stem cells were then identified by immunohistochemistry. Results: Serological identification for H. pylori Antigen and Antibodies revealed (63% human, 50% dogs) and (87% human, 90% dogs) respectively were positive. Genotyping of H. pylori based on 16S rRNA gene showed 54.5% of human and 35% of dogs were positive. Immunohistochemistry revealed strong expression of CD44 in H. pylori- associated gastric cancer cases, MMP-2 expression was observed in all neoplastic lesions associated with H. pylori infection. Conclusion: H. pylori infection affects gastric mucosa and induces changes in gastric stem cells altering their differentiation and increased expression of MMP’s and CD44with a resultant potentiation of oncogenic alteration. In addition the up-regulation of both markers could be an instrumental to interpret the origination of gastric cancer.

P0006 Hyperthermia augments sensitivity of gastric cancer stem cells to chemotherapy by inhibiting repair of dna damage

2014 ◽  
Vol 50 ◽  
pp. e10-e11
Author(s):  
M.C. Ba ◽  
H. Long ◽  
X.L. Zhang ◽  
Y.Q. Tang ◽  
F.H. Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Gastric Cancer Stem Cells

scholarly journals The Discovery of CD44R as a Marker for Gastric Cancer Stem Cells

2011 ◽  
Vol 140 (5) ◽  
pp. S-830
Author(s):  
Eileen Teng ◽  
Wen Min Lau ◽  
Hui Shan Chong ◽  
Kirsten A. Lopez ◽  
Amy Y. Tay ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Gastric Cancer Stem Cells
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