scholarly journals Proton pump inhibitor pantoprazole inhibits the proliferation, self-renewal and chemoresistance of gastric cancer stem cells via the EMT/β-catenin pathways

2016 ◽  
Vol 36 (6) ◽  
pp. 3207-3214 ◽  
Author(s):  
Shuitu Feng ◽  
Zhigao Zheng ◽  
Lihua Feng ◽  
Lihong Yang ◽  
Zuhong Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Self Renewal ◽  
Gastric Cancer Stem Cells

scholarly journals Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

Biomedicines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 7 ◽  
Author(s):  
Lingfeng Fu ◽  
Luke Bu ◽  
Tadahito Yasuda ◽  
Mayu Koiwa ◽  
Takahiko Akiyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Chemotherapy Resistance ◽  
Immune Microenvironment ◽  
Self Renewal ◽  
Current Review ◽  
Gastric Cancer Stem Cells ◽  
Novel Therapeutic Strategies ◽  
The Relationship

Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs.

scholarly journals Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells

2015 ◽  
Vol 36 (6) ◽  
pp. 1657-1663 ◽  
Author(s):  
ZHENZHEN WEN ◽  
SHUJIONG FENG ◽  
LIJUAN WEI ◽  
ZHIMIN WANG ◽  
DEFEI HONG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Pathway ◽  
The Self ◽  
Self Renewal ◽  
Gastric Cancer Stem Cells

scholarly journals The Role of HER2 in Self-Renewal, Invasion, and Tumorigenicity of Gastric Cancer Stem Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Li-Fei Sun ◽  
Kun Yang ◽  
Yi-Gao Wang ◽  
Yu-Xin Liu ◽  
Pei-Xian Hou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Self Renewal ◽  
Gastric Cancer Stem Cells

scholarly journals MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells

2013 ◽  
Vol 126 (18) ◽  
pp. 4220-4229 ◽  
Author(s):  
Q. Wu ◽  
Z. Yang ◽  
F. Wang ◽  
S. Hu ◽  
L. Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
The Self ◽  
Self Renewal ◽  
Gastric Cancer Stem Cells

Increased Production of Matrix Metalloproteinases in Helicobacter pylori Infection that Stimulates Gastric Cancer Stem Cells

2020 ◽  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Helicobacter Pylori ◽  
Cancer Stem Cells ◽  
Histopathological Examination ◽  
Physiological Saline ◽  
Rrna Gene ◽  
Peptic Ulcers ◽  
Gastric Cancer Stem Cells ◽  
H Pylori

Background and aim: Helicobacter pylori (H. pylori) is an incriminated pathogen causing diseases in both animals and humans and considered a zoonotic pathogen. H. pylori infection is considered a cause of gastric cancer, which rests a significant health care challenge. This study analyzes the expression pattern of matrix metalloprotein 2 (MMP-2) in patients with Helicobacter pylori-associated gastritis and the effect of H. pylori on gastric cancer stem cells, as well as study the role of helicon bacteriosis in dog in transmission of H. pylori infection to human. Materials and methods: Fifty-five of each sample (gastric biopsy, blood and stool) were collected from patients suffering from dyspepsia, chronic vomiting and perforated peptic ulcers and also from apparent healthy dogs. The investigation detected H. pylori by serological and histopathological examination. Biopsies were stored in physiological saline for identification of H. pylori by conventional time PCR. MMP-2 and Gastric cancer stem cells were then identified by immunohistochemistry. Results: Serological identification for H. pylori Antigen and Antibodies revealed (63% human, 50% dogs) and (87% human, 90% dogs) respectively were positive. Genotyping of H. pylori based on 16S rRNA gene showed 54.5% of human and 35% of dogs were positive. Immunohistochemistry revealed strong expression of CD44 in H. pylori- associated gastric cancer cases, MMP-2 expression was observed in all neoplastic lesions associated with H. pylori infection. Conclusion: H. pylori infection affects gastric mucosa and induces changes in gastric stem cells altering their differentiation and increased expression of MMP’s and CD44with a resultant potentiation of oncogenic alteration. In addition the up-regulation of both markers could be an instrumental to interpret the origination of gastric cancer.

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