Work Stress, Obesity and the Risk of Type 2 Diabetes: Gender-Specific Bidirectional Effect in the Whitehall II Study

Obesity ◽  
2012 ◽  
Vol 20 (2) ◽  
pp. 428-433 ◽  
Author(s):  
Alexandros M. Heraclides ◽  
Tarani Chandola ◽  
Daniel R. Witte ◽  
Eric J. Brunner
Keyword(s):  
Type 2 Diabetes ◽  
Work Stress ◽  
Gender Specific

312-OR: Gender-Specific Effects on Hepatic Fat Metabolism in Type 2 Diabetes before and after Remission

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 312-OR
Author(s):  
AHMAD AL-MRABEH ◽  
SHADEN MELHEM ◽  
SVIATLANA V. ZHYZHNEUSKAYA ◽  
CARL PETERS ◽  
ALISON C. BARNES ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fat Metabolism ◽  
Specific Effects ◽  
Before And After ◽  
Hepatic Fat ◽  
Gender Specific

scholarly journals Influence of gender on the distribution of type 2 diabetic complications at the obafemi awolowo teaching hospital, Ile-Ife, Nigeria

2020 ◽  
Vol 20 (1) ◽  
pp. 294-307
Author(s):  
Adenike Enikuomehin ◽  
Babatope A Kolawole ◽  
Olubukunmi D Soyoye ◽  
Joseph O Adebayo ◽  
Rosemary T Ikem
Keyword(s):  
Type 2 Diabetes ◽  
Macrovascular Complications ◽  
Diabetes Clinic ◽  
Therapeutic Goals ◽  
Study Population ◽  
Gender Specific Differences ◽  
Males And Females ◽  
Microvascular And Macrovascular Complications ◽  
Gender Specific

Background: Sex specific differences appear particularly relevant in the management of type 2 DM. Objective: We determined gender specific differences in cardio-metabolic risk, microvascular and macrovascular complications in patients with type 2 diabetes. Methods: Four hundred type 2 diabetes patients, males and females, matched for age and disease duration were recruited from the diabetes clinic. Relevant clinical and laboratory information were obtained or performed. Results: 190(47.5%) were male and 210 (52.5%) were female respectively. The mean age of the study population was 60.6 + 9.93 years. Women had higher prevalence of hypertension (and obesity. Mean total cholesterol was significantly higher in women but men were more likely to achieve LDL treatment goals than women (69.5% vs 59.0%, p<0.05). More women (47.1% & 31.4%) reached glycaemic goals of <10mmol/l for 2HPP and HBA1c of <7.0%. There were no gender differences in the distribution of microvascular and macrovascular complications (p>0.05) but women were more likely to develop moderate and severe diabetic retinopathy (p= 0.027). Conclusion: Women with T2DM had worse cardiometabolic risk profile with regards to hypertension, obesity and lipid goals. Men achieved therapeutic goals less frequently than did women in terms of glycaemia. Microvascular and macrovascular com- plications occurred commonly in both sexes. Keywords: Type 2 diabetes; gender; microvascular; macrovascular complication; cardiometabolic risks; glycaemic control. 

scholarly journals Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 683
Author(s):  
Valentina Rosta ◽  
Alessandro Trentini ◽  
Angelina Passaro ◽  
Giovanni Zuliani ◽  
Juana Maria Sanz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Complications ◽  
Serum Glucose ◽  
Paraoxonase 1 ◽  
High Density Lipoproteins ◽  
Pon1 Activity ◽  
Partial Loss ◽  
The Relationship ◽  
Gender Specific

Type-2 diabetes (T2D) and its cardiovascular complications are related to sex. Increasing evidence suggests that paraoxonase 1 (PON1) activity, an antioxidant enzyme bound to high-density lipoproteins (HDL), is implicated in the onset and clinical progression of T2D. Since we previously showed that PON1 is a sexual dimorphic protein, we now investigated whether sex might impact the relationship between PON1 and this chronic disease. To address this aim, we assessed PON1 activity in the sera of 778 patients, including controls (women, n = 383; men, n = 198) and diabetics (women, n = 79; men = 118). PON1 activity decreased in both women and men with T2D compared with controls (p < 0.05 and p > 0.001, respectively), but the change was 50% larger in the female cohort. In line with this result, the enzyme activity was associated with serum glucose level only in women (r = −0.160, p = 0.002). Notably, only within this gender category, lower PON1 activity was independently associated with increased odds of being diabetic (odds ratio (95% Confidence interval: 2.162 (1.075–5.678)). In conclusion, our study suggests that PON1-deficiency in T2D is a gender-specific phenomenon, with women being more affected than men. This could contribute to the partial loss of female cardiovascular advantage associated with T2D.

The absence of gender specific of KCNJ11 E23K variant with risk of type 2 diabetes in a population in Iran, Guilan

2011 ◽  
Vol 44 (13) ◽  
pp. S299
Author(s):  
Ghasemi Malaeke ◽  
Keshavarz Parvaneh ◽  
Habibi Razieh ◽  
Hedayati emami Mohammad Hassan ◽  
Kazemnejad Ehsan
Keyword(s):  
Type 2 Diabetes ◽  
Gender Specific

scholarly journals Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers

2012 ◽  
Vol 97 (12) ◽  
pp. E2282-E2287 ◽  
Author(s):  
Saad H. Alzahrani ◽  
Katharina Hess ◽  
Jackie F. Price ◽  
Mark Strachan ◽  
Paul D. Baxter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Structure Function ◽  
Vascular Markers ◽  
Gender Specific ◽  
Fibrin Structure

Gender-specific effects of oral hypoglycaemic agents on cancer risk in type 2 diabetes mellitus

2013 ◽  
Vol 16 (3) ◽  
pp. 276-283 ◽  
Author(s):  
G. E. C. Sun ◽  
B. J. Wells ◽  
K. Yip ◽  
R. Zimmerman ◽  
D. Raghavan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cancer Risk ◽  
Oral Hypoglycaemic Agents ◽  
Hypoglycaemic Agents ◽  
Specific Effects ◽  
Gender Specific
Sign in / Sign up

Export Citation Format

Share Document