scholarly journals Visceral Fat Accumulation Induced by a High-fat Diet Causes the Atrophy of Mesenteric Lymph Nodes in Obese Mice

Obesity ◽  
2008 ◽  
Vol 16 (6) ◽  
pp. 1261-1269 ◽  
Author(s):  
C.S. Kim ◽  
S.C. Lee ◽  
Y.M. Kim ◽  
B.S. Kim ◽  
H.S. Choi ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Mesenteric Lymph Nodes ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Mesenteric Lymph

Lactobacillus plantarum Shinshu N-07 isolated from fermented Brassica rapa L. attenuates visceral fat accumulation induced by high-fat diet in mice

2020 ◽  
pp. 1-14
Author(s):  
T. Yin ◽  
S. Bayanjargal ◽  
B. Fang ◽  
C. Inaba ◽  
M. Mutoh ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lactobacillus Plantarum ◽  
Brassica Rapa ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Uncoupling Protein ◽  
Epididymal Adipose Tissue ◽  
High Fat ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation

Lactobacillus plantarum Shinshu N-07 (N07) and Lactobacillus curvatus #4G2 (#4G2) were isolated from fermented Brassica rapa L. and selected as promising probiotics with anti-adiposity activities based on in vitro assays. The anti-adiposity effects of these two strains were investigated using a diet-induced obesity animal model. Epididymal adipose tissue weight and adipocyte area were significantly lower and serum triglycerides and glucose tended to be lower in mice fed the high-fat diet supplemented with N07 compared with those fed the unsupplemented high-fat diet. Strain N07 suppressed hepatic steatosis, with accompanying downregulation of lipogenic genes in the liver. Expression of inflammatory cytokines and macrophage infiltration markers tended to be suppressed by N07 supplementation. Upregulation of uncoupling protein-1 in epididymal adipose tissue by N07 suggested that the transformation of white adipose tissue to brown might have been induced. Intestinal microbiota analysis revealed that a decrease in abundance of family S24-7 (phylum Bacteroidetes) following ingestion of the high-fat diet was partly recovered by supplementation with N07. Changes in those parameters were not observed in mice fed the high-fat diet supplemented with strain #4G2, suggesting strain specificities. Thus, N07 is a potential probiotic strain that could be used to develop functional foods that attenuate visceral fat accumulation after an appropriate human intervention trial.

scholarly journals Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats

2015 ◽  
Vol 64 (12) ◽  
pp. 1243-1250 ◽  
Author(s):  
Azusa Takahashi ◽  
Hisae Shimizu ◽  
Yukako Okazaki ◽  
Hirohide Sakaguchi ◽  
Toshio Taira ◽  
...  
Keyword(s):  
Visceral Fat ◽  
High Fat Diet ◽  
High Fat ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation ◽  
Obese Rats

scholarly journals Heat‐killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high‐fat diet in mice

2021 ◽  
Author(s):  
Jun Watanabe ◽  
Naoto Hashimoto ◽  
Tingyu Yin ◽  
Bayanjargal Sandagdorj ◽  
Chinatsu Arakawa ◽  
...  
Keyword(s):  
Visceral Fat ◽  
High Fat Diet ◽  
Lactobacillus Brevis ◽  
High Fat ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation

scholarly journals Health Effects of Alternate Day Fasting Versus Pair-Fed Caloric Restriction in Diet-Induced Obese C57Bl/6J Male Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Chloe G. Henderson ◽  
Damian L. Turner ◽  
Steven J. Swoap
Keyword(s):  
T Cell ◽  
Caloric Restriction ◽  
High Fat Diet ◽  
Chow Diet ◽  
Obese Mice ◽  
High Fat ◽  
Mesenteric Lymph Nodes ◽  
Fasting Period ◽  
Alternate Day Fasting ◽  
Ad Libitum

Alternate day fasting (ADF) induces weight loss and improves various markers of health in rodents and humans. However, it is unclear whether the benefits of ADF are derived from the lower caloric intake of ADF or from the 24-h fasting period. Therefore, this study directly compared selected markers for health – such as glucose control, body weight, liver triglycerides, T cell frequencies, and others – in high-fat (60% calories from fat) diet-induced obese mice subjected to either ADF or caloric restriction (CR). Obese mice were randomly assigned to one of four groups: (1) ADF: remained on the high-fat diet, but fed on alternate days (n = 5), (2) PF: remained on the high-fat diet, but pair-fed to the ADF group (n = 5), (3) LF: moved to a chow ad libitum diet (n = 5; 17% calories from fat), and (4) HF: remained on the high-fat ad libitum diet (n = 5). An additional group of non-obese mice maintained on a chow diet since weaning were used as controls (CON: n = 5). After 10 weeks, ADF, PF, and LF mice ate fewer kcals, had a lower body mass, had smaller epididymal fat pads, improved glucose tolerance, and had a lower hepatic triglyceride content relative to HF mice (p < 0.05), but none reached that of CON mice in these measures. T cell frequencies of the spleen, blood, and mesenteric lymph nodes were reduced in ADF, PF, and HF compared to the CON group. Importantly, there were no significant differences between the ADF and PF groups in any of the measurements made in the current study. These data suggest that ADF, PF, and LF diets each lead to improved markers of health relative to high-fat diet-induced obese mice, and that the caloric restriction associated with ADF is the major factor for the noted improvements.

scholarly journals High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice

2019 ◽  
Vol 59 (4) ◽  
pp. 1641-1654 ◽  
Author(s):  
Aaron M. Magnuson ◽  
Daniel P. Regan ◽  
Andrea D. Booth ◽  
Josephine K. Fouts ◽  
Claudia M. Solt ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Central Adiposity ◽  
High Fat ◽  
Mesenteric Lymph
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