scholarly journals Zinc-Induced Hyperleptinemia Relates to the Amelioration of Sucrose-Induced Obesity with Zinc Repletion

2000 ◽  
Vol 8 (7) ◽  
pp. 525-529 ◽  
Author(s):  
Ming-Der Chen ◽  
Pi-Yao Lin
Keyword(s):  
1984 ◽  
Vol 247 (1) ◽  
pp. E88-E93 ◽  
Author(s):  
H. C. Lukaski ◽  
W. W. Bolonchuk ◽  
L. M. Klevay ◽  
D. B. Milne ◽  
H. H. Sandstead

For 30 days five healthy men aged 23-57 yr consumed a diet adequate in zinc (8.6 mg/day); they ate a low-zinc diet (3.6 mg/day) for the next 120 days and then received a zinc-supplemented (33.6 mg/day) diet for 30 days. Copper intake was constant at 1.8 mg/day. Aerobic capacity was determined periodically during each diet period. Relative zinc balance (% of control) declined during depletion (r = -0.28, P less than 0.009). Pre- and postexercise zinc concentrations decreased when dietary zinc was restricted (r = -0.61, P less than 0.0001 and r = -0.78, P less than 0.0001) and increased with supplementation (r = 0.61, P less than 0.008 and r = 0.76, P less than 0.0003, respectively). Both plasma zinc and hematocrit increased (P less than 0.01) after maximal exercise. To minimize the effect of hemoconcentration during exercise, the van Beaumont quotient (J. Appl. Physiol. 34: 102-106, 1973) was calculated using pre- and postexercise hematocrit and plasma zinc. The initial quotient of 1.8 +/- 1.8% (mean +/- SE) declined (P less than 0.05) to -7.4 +/- 2.3% during depletion. With zinc repletion, the quotient increased to 6.9 +/- 3.6%, which was greater (P less than 0.05) than the quotient in depletion but similar to the initial quotient. The quotient was a strong predictor (r = 0.71, P less than 0.0005) of the change in relative zinc balance during zinc depletion. In contrast, no changes were found in plasma copper content. These data suggest that zinc mobilization from tissues is impaired during zinc depletion, and they validate the use of the van Beaumont quotient as an index of change in body zinc stores.


1982 ◽  
Vol 112 (5) ◽  
pp. 1019-1028 ◽  
Author(s):  
Karl E. Mason ◽  
Willard A. Burns ◽  
J. Cecil Smith

1997 ◽  
Vol 75 (11) ◽  
pp. 3074 ◽  
Author(s):  
T E Engle ◽  
C F Nockels ◽  
C V Kimberling ◽  
D L Weaber ◽  
A B Johnson

1985 ◽  
Vol 3 (4) ◽  
pp. 192-198 ◽  
Author(s):  
G. Stammler ◽  
P. Klooker ◽  
J. Bommer ◽  
T. Ziegler ◽  
W. Fiehn ◽  
...  

1979 ◽  
Vol 236 (3) ◽  
pp. E272 ◽  
Author(s):  
A S Prasad ◽  
F Fernandez-Madrid ◽  
J R Ryan

The activity of deoxythymidine kinase was assayed in implanted sponge connective tissue in three groups of subjects: 1) five normal controls (having normal levels of plasma and red cell zinc); 2) four patients with sickle cell anemia who had low zinc in red cells and hair; and 3) two volunteers (under strict dietary controls), after 6 mo of zinc restriction (2.7 mg/day) and repeated after 3 mo of zinc repletion (30 mg/day). Total protein, total collagen, RNA/DNA, and deoxythymidine kinase activity were measured by techniques reported previously. In sickle cell anemia patients, deoxythymidine kinase activity was not detected, and RNA/DNA, total collagen, and total protein contents were decreased compared to normal controls (statistically significant). In human volunteers deoxythymidine kinase activity was not detected during the zinc restriction phase. After supplementation with zinc, deoxythymidine kinase activity became 70% of normal control levels, and RNA/DNA, total collagen, and total protein contents of sponge connective tissue increased. In conclusion, an adverse effect of zinc deficiency on deoxythymidine kinase activity of implanted sponge connective tissue of man has been demonstrated for the first time.


2009 ◽  
Vol 23 (3) ◽  
pp. 176-182 ◽  
Author(s):  
Elzbieta I. Szczurek ◽  
Chris S. Bjornsson ◽  
Amy D. Noto ◽  
Carla G. Taylor
Keyword(s):  

1990 ◽  
Vol 52 (1) ◽  
pp. 166-172 ◽  
Author(s):  
P K Fenwick ◽  
P J Aggett ◽  
D Macdonald ◽  
C Huber ◽  
D Wakelin

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