scholarly journals Association of carotid artery intima–media thickness with CKD in patients without cardiovascular disease

2010 ◽  
Vol 6 (4) ◽  
pp. 190-190
Author(s):  
Susan J. Allison
Keyword(s):  
Cardiovascular Disease ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Media Thickness

scholarly journals Association of α2-Heremans-Schmid Glycoprotein Polymorphisms with Subclinical Atherosclerosis

2007 ◽  
Vol 92 (1) ◽  
pp. 345-352 ◽  
Author(s):  
Allison B. Lehtinen ◽  
Kathryn P. Burdon ◽  
Joshua P. Lewis ◽  
Carl D. Langefeld ◽  
Julie T. Ziegler ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Carotid Artery ◽  
Atherosclerotic Plaque ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Fetuin A ◽  
Media Thickness ◽  
European Americans ◽  
Calcified Plaque ◽  
Ahsg Gene

Abstract Context: Cardiovascular disease is significantly increased in individuals with type 2 diabetes mellitus (T2DM), especially in the presence of calcified atherosclerotic plaque. Fetuin A is an important mineralization inhibitor, and polymorphisms in the corresponding α2-Heremans-Schmid glycoprotein (AHSG) gene have been shown to be associated with serum fetuin A levels and free phosphate levels, as well as cardiovascular disease death. Objective: This study investigated whether polymorphisms in AHSG contribute to the development of calcified atherosclerotic plaque in the coronary and carotid arteries and to carotid artery intima-media thickness. Design: Eleven single nucleotide polymorphisms (SNPs) in AHSG were genotyped and evaluated for association with quantitative measures of subclinical atherosclerosis. Participants: Subjects were 829 T2DM-affected European Americans from 368 families in the Diabetes Heart Study. Main Outcome Measures: Participants were phenotyped for cardiovascular risk factors and atherosclerosis traits. The extent of coronary artery calcified plaque (CorCP) and carotid artery calcified plaque (CarCP) was measured using quantitative computed tomography, and carotid artery intima-media thickness was measured using high-resolution B mode ultrasonography. Results: Four SNPs in AHSG were nominally associated with CorCP in European Americans with T2DM (P < 0.05). Two 3-SNP haplotypes in the exon 6–7 region were associated with CorCP in European Americans with T2DM (P < 0.06). Conclusions: Sequence variants in the AHSG gene affect the extent of CorCP in T2DM-affected European Americans, consistent with the known biological role of AHSG in vascular calcification. These data implicate AHSG in the development of vascular calcified plaque in diabetic subjects.

scholarly journals Associations of Carotid Artery Intima-Media Thickness (IMT) With Risk Factors and Prevalent Cardiovascular Disease

2010 ◽  
Vol 29 (12) ◽  
pp. 1759-1768 ◽  
Author(s):  
Joseph F. Polak ◽  
Michael J. Pencina ◽  
Allison Meisner ◽  
Karol M. Pencina ◽  
Lisa S. Brown ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Media Thickness

scholarly journals Adipokines and Subclinical Cardiovascular Disease in Post‐Menopausal Women: Study of Women's Health Across the Nation

2021 ◽  
Author(s):  
Susan A. Everson‐Rose ◽  
Emma J. M. Barinas‐Mitchell ◽  
Samar R. El Khoudary ◽  
Hsin‐Hui Huang ◽  
Qi Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Carotid Artery ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Intima Media Thickness ◽  
Cardiovascular Disease Risk Factors ◽  
Media Thickness ◽  
Subclinical Cardiovascular Disease ◽  
Post Menopausal

Background The menopausal transition is characterized by increased cardiovascular risk, weight gain, and increased adiposity for many women. The adipose‐derived secretory proteins adiponectin and leptin are associated with insulin resistance, metabolic syndrome, and cardiovascular disease but their role in subclinical atherosclerotic disease is unclear. This cross‐sectional study evaluated the associations of adiponectin and leptin with carotid artery intima‐media thickness, adventitial diameter, presence of carotid plaques, and brachial‐ankle pulse wave velocity (baPWV) in women aged 54 to 65 years. Methods and Results Participants were 1399 women from SWAN (Study of Women's Health Across the Nation), a community‐based study of women transitioning through menopause. Carotid ultrasound and baPWV measures were obtained at SWAN follow‐up visits 12 or 13, when 97% of participants were post‐menopausal. Adipokines were assayed from serum specimens obtained concurrently at these visits. Linear and logistic regression models were used to evaluate adiponectin or leptin, both log‐transformed attributable to skewness, in relationship to carotid artery intima‐media thickness, adventitial diameter, baPWV, and presence of carotid plaque. Covariates included age, race, study site, smoking, alcohol use, obesity, cardiovascular disease risk factors, and menopausal status. Lower levels of adiponectin were related to greater carotid artery intima‐media thickness, wider adventitial diameter, and faster baPWV; associations were attenuated after adjusting for cardiovascular disease risk factors. Higher levels of leptin were associated with greater carotid artery intima‐media thickness and wider adventitial diameter in minimally and fully adjusted models, and contrary to expectation, with slower baPWV, particularly among women with diabetes mellitus or obesity. Conclusions Adiponectin and leptin are 2 important inflammatory pathways that may contribute to adverse subclinical cardiovascular disease risk profiles in women at midlife.

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